Rising Trend in the Prevalence of HPV-Driven Oropharyngeal Squamous Cell Carcinoma during 2000–2022 in Northeastern Italy: Implication for Using p16INK4a as a Surrogate Marker for HPV-Driven Carcinogenesis

Boscolo‐Rizzo, Paolo; Polesel, Jerry; Mistro, Annarosa Del; Fratta, Elisabetta; Lazzarin, Chiara; Menegaldo, Anna; Lupato, Valentina; Fanetti, Giuseppe; Zanconati, Fabrizio; Guido, Maria; Giacomarra, Vittorio; Emanuelli, Enzo; Tofanelli, Margherita; Tirelli, Gian Carlo

doi:10.3390/cancers15092643

Cited by 9 publications

(1 citation statement)

References 47 publications

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“…CDKN2A, also known as cyclin dependent kinase inhibitor 2A/p16, plays an important role in the occurrence and development of head and neck squamous cell carcinoma (HNSCC) and is a well-known tumor suppressor gene, particularly in HPV-related HNSCC. [15,16] Our study also found that low CDKN2A expression in TSCC was significantly associated with a poor prognosis (Figure S1B, Supplemental Digital Content, http://links.lww.com/MD/K753 and Figure S2B, Supplemental Digital Content, http://links.lww.com/MD/K754), indicating the importance of CDKN2A in TSCC. CAs are a class of large zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide and participate in a variety of biological processes.…”

Section: Discussionsupporting

confidence: 65%

Construction and validation of a prognostic model for tongue cancer based on three genes signature

Tan,

Huang,

Yang

et al. 2023

Medicine

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Tongue squamous cell carcinoma (TSCC) has a poor prognosis and destructive characteristics. Reliable biomarkers are urgently required to predict disease outcomes and to guide TSCC treatment. This study aimed to develop a multigene signature and prognostic nomogram that can accurately predict the prognosis of patients with TSCC. We screened differentially expressed genes associated with TSCC using The Cancer Genome Atlas dataset. Based on this, we developed a new multi-mRNA gene signature using univariate Cox regression, Least Absolute Shrinkage and Selection Operator regression, and multivariate Cox regression. We used the concordance index to evaluate the accuracy of this new multigene model. Moreover, we performed receiver operating characteristic and Kaplan–Meier survival analyses to assess the predictive ability of the new multigene model. In addition, we created a prognostic nomogram incorporating clinical and pathological characteristics, with the aim of enhancing the adaptability of this model in practical clinical settings. We successfully developed a new prognostic model based on the expression levels of these 3 mRNAs that can be used to predict the prognosis of patients with TSCC. This prediction model includes 3 genes: KRT33B, CDKN2A, and CA9. In the validation set, the concordance index of this model was 0.851, and the area under the curve was 0.778 and 0.821 in the training and validation sets, respectively. Kaplan–Meier survival analysis showed that regardless of whether it was in the training or validation set, the prognosis of high-risk patients was significantly worse than that of low-risk patients (P < .001). Multivariate Cox regression analysis revealed that this model was an independent prognostic factor for patients with TSCC (P < .001). Our study suggests that this 3-gene signature model has a high level of accuracy and predictive ability, is closely related to the overall survival rate of patients with TSCC, and can independently predict the prognosis of TSCC patients with high accuracy and predictive ability.

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Section: Discussionsupporting

confidence: 65%

Construction and validation of a prognostic model for tongue cancer based on three genes signature

Tan,

Huang,

Yang

et al. 2023

Medicine

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HPV overtakes smoking as the leading cause of oropharyngeal cancer in Ireland: experience of a head and neck surgery tertiary referral centre

Cleere,

Murphy,

Crotty

et al. 2024

Ir J Med Sci

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Background Worldwide, the incidence of oropharyngeal squamous cell carcinoma (OPSCC) caused by human papillomavirus (HPV), a sexually transmitted virus, is increasing. This increase has yet to be demonstrated in an Irish cohort. Aims To evaluate the number of OPSCC presentations locally, to stratify cases by HPV status and to estimate if any changes in the patient population had occurred over a 10-year period. Methods A STROBE-compliant, retrospective evaluation of patients with OPSCC at St James’s Hospital between 2012 and 2022 was performed. Patients with non-SCC histology, undocumented HPV status and residual or recurrent tumours were excluded. Results We included 294 patients with a mean age of 60.4 years (95% CI 59.2–61.5 years) and 175 (59.5%) patients had HPV+ OPSCC. The number of new OPSCC diagnoses increased from 115 patients (39.1%) between 2012 and 2016 to 179 patients (60.9%) between 2017 and 2021. This was associated with an increased proportion of HPV-linked OPSCC (50.4% 2012–2016 vs. 65.4% 2017–2021, p = 0.011). Over time, more patients had a functionally limiting comorbidity (p = 0.011). The mean age of HPV+ OPSCC cases increased by 3.6 years (p = 0.019). Patients with HPV+ OPSCC had greater 2-year OS (83.9% vs. 54.9%; p < 0.001) and 2-year DFS (73.5% vs. 45.6%; p < 0.001). The 2-year OS and DFS did not change over time for HPV+ or HPV− patients. Conclusions In our institution, the number of patients with OPSCC is increasing due to an escalation in cases associated with HPV. Population-level interventions such as vaccination programs may alter the current increase in the incidence of these tumours.

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Human Papillomaviruses 16 and 18 E6 Oncoprotein Detection Test in Primary Oropharyngeal Carcinomas and Metastatic Lymph Nodes: A Cross-Sectional Study

Boscolo-Rizzo,

Polesel,

Menegaldo

et al. 2024

Head and Neck Pathol

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Rising Trend in the Prevalence of HPV-Driven Oropharyngeal Squamous Cell Carcinoma during 2000–2022 in Northeastern Italy: Implication for Using p16INK4a as a Surrogate Marker for HPV-Driven Carcinogenesis

Cited by 9 publications

References 47 publications

Construction and validation of a prognostic model for tongue cancer based on three genes signature

Construction and validation of a prognostic model for tongue cancer based on three genes signature

HPV overtakes smoking as the leading cause of oropharyngeal cancer in Ireland: experience of a head and neck surgery tertiary referral centre

Human Papillomaviruses 16 and 18 E6 Oncoprotein Detection Test in Primary Oropharyngeal Carcinomas and Metastatic Lymph Nodes: A Cross-Sectional Study

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