BackgroundComparing heart failure (HF) outcomes across hospitals requires adequate risk adjustment. We aimed to develop and validate a model that can be used to compare quality of HF care across hospitals.Methods and ResultsWe included patients with HF aged â„18 years admitted to one of 433 hospitals that participated in the Premier Inc Data Warehouse. This model (Premier) contained patient demographics, comorbidities, and acute conditions present on admission, derived from administrative and billing records. In a separate data set derived from electronic health records, we validated the Premier model by comparing hospital riskâstandardized mortality rates calculated with the Premier model to those calculated with a validated clinical model containing laboratory data (LAPS [LaboratoryâBased Acute Physiology Score]). Among the 200 832 admissions in the Premier Inc Data Warehouse, inpatient mortality was 4.0%. The model showed acceptable discrimination in the warehouse data (C statistic 0.75; 95% confidence interval, 0.74â0.76). In the validation data set, both the Premier model and the LAPS models showed acceptable discrimination (C statistic: Premier: 0.76 [95% confidence interval, 0.74â0.77]; LAPS: 0.78 [95% confidence interval, 0.76â0.80]). Riskâstandardized mortality rates for both models ranged from 2% to 7%. A linear regression equation describing the association between Premierâ and LAPSâspecific mortality rates revealed a regression line with a slope of 0.71 (SE: 0.07). The correlation coefficient of the standardized mortality rates from the 2 models was 0.82.ConclusionsCompared with a validated model derived from clinical data, an HF mortality model derived from administrative data showed highly correlated riskâstandardized mortality rate estimates, suggesting it could be used to identify highâ and lowâperforming hospitals for HF care.