Risk Analysis of Specific Environmental Heavy Metals as a Trigger of CD4 &amp; CD8 Among Cases of Multiple Sclerosis:Case - control study.

Elberry, Reda Ataarabeh; Alazab, Raed; Hady, Aymen Abdel; Sobh, Khalid; Abdellatif, Salama S; Elsayed, A. Z. A.

doi:10.21608/aimj.2020.27847.1198

Cited by 1 publication

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“…Elberry et al [25] quantitated blood levels of Pb, Hg and Cd in 50 Cases with a diagnosis of definite, probable or possible MS and 50 healthy controls at El-Hussein University Hospital, Cairo, Egypt. MS group possessed higher levels of both Pb and Hg than controls, which was constituent with our results.…”

Section: Discussionmentioning

confidence: 99%

Complex Profile of Altered Heavy Metals Accumulation in Multiple Sclerosis, a Relationship with Copper and Zinc Homeostasis

Mohamed

Fadl

Tork

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Multiple sclerosis (MS) is a demyelinating inflammatory disease of the central nervous system white matter. Both of environmental and genetic factors have been implicated in its pathogenesis. Heavy metals generate free radicals causing alteration in genetic material and blood-brain barrier damage. In addition, intracellular accumulation of certain heavy metals can trigger autoimmune reaction against myelin proteins and nerves cytoskeletal proteins. AIM: We aimed to analyse complex profile of altered heavy metals accumulation in multiple sclerosis and relationship with copper and zinc homeostasis. METHODS: The present study was carried out in the period between September 2019 and May 2021 on 86 MS Egyptian patients and 86 age and gender matched healthy controls. Whole blood levels of lead (Pb), mercury (Hg), and Cadmium (Cd) in microgram/liter (μg/L) in addition to Zinc (Zn) and Copper (Cu) in milligram/liter (mg/L) were quantitated using the Agilent ICP-MS-MS. The current study also discussed physiological-toxic metals interactions in these patients. RESULTS: We demonstrated significant relations between toxic heavy metals levels and MS suggested by significantly higher levels of Pb, Hg, and Cd and significantly lower levels of Zn and Cu as well as Cu/ Zn in MS patients than controls. Besides, it could be assumed that; physiological heavy metals homeostasis limits the accumulation of toxic heavy metals that share absorption and transport binding sites, suggested by the significant negative correlations between whole blood levels of Cu and both of Hg and Pb. CONCLUSION: A complex profile of altered elements rather than a single element imbalance in MS pathogenesis is suggested.

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Section: Discussionmentioning

confidence: 99%