Risk and Prognosis of Hospitalization for Pneumonia Among Individuals With and Without Functioning Renal Transplants in Denmark: A Population-Based Study

Nielsen, Lise Hald; Jensen-Fangel, Søren; Jespersen, Bente; Østergaard, Lars; Søgaard, Ole Schmeltz

doi:10.1093/cid/cis488

Cited by 17 publications

(8 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Chuang et al and Dantes et al found receiving an organ transplant from deceased donor was independently associated with an increased risk of post-transplant UTI. However, we did not find this association in our present study or in previous studies looking at infection-risk in transplant recipients [ 23 , 24 ].…”

Section: Discussioncontrasting

confidence: 99%

Risk and outcome of pyelonephritis among renal transplant recipients

et al. 2016

Self Cite

View full text Add to dashboard Cite

BackgroundUrinary tract infection is the most common infectious disease requiring hospitalisation following renal transplantation. However, the risk and outcome of post-transplant pyelonephritis remains unclear.MethodsThis population-based cohort study was conducted from 1 January 1990 to 31 December 2009. Each member of a Danish population-based, nationwide cohort of first-time renal transplant recipients was matched by age and gender with up to 19 population controls. Information on hospital discharge diagnosis, emigration, and mortality was obtained from nationwide administrative databases. Individuals were observed from the date of first renal transplantation and until graft loss, emigration, or death. Risk factors were assessed by Poisson regression.ResultsThe incidence rate (IR) of first-time hospitalisation for pyelonephritis was 18.5 (95 % confidence interval [CI]: 16.4–20.9) per 1,000 person-years of follow-up (PYFU) among renal transplant recipients (N = 2,656) and 0.26 (CI: 0.21–0.31) per 1,000 PYFU among population controls (N = 49,226) yielding an incidence rate-ratio (IRR) of 72.0 (95 % CI: 57.8–89.7). Among renal transplant recipients, the risk of pyelonephritis decreased during the entire study period and was lowest in 2005–09 (IRR = 0.46, CI: 0.31–0.68). The highest risk of pyelonephritis was observed within the first six months post-transplantation (IR = 69.9 per 1,000 PYFU; CI: 56.4–86.7). Other risk factors for post-transplant pyelonephritis included female gender, high Charlson comorbidity index score, HLA-DR mismatch, cause of renal failure, and calendar period. Interestingly, we found that the combined risk of graft loss and death was 45 %, (CI: 19–77 %) higher in renal transplant recipients following post-transplant pyelonephritis compared to those who had no admission due to pyelonephritis.ConclusionsThe risk of first-time hospitalisation for pyelonephritis among renal transplant recipients is high. Further, post-transplant pyelonephritis was associated with excess risk of graft loss and death; this indicates that strategies aimed at reducing upper urinary tract infections are likely to enhance renal graft survival.

show abstract

Section: Discussioncontrasting

confidence: 99%

Risk and outcome of pyelonephritis among renal transplant recipients

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…27,28 This is supported by the epidemiological evidence that patients with weakened immune systems, (e.g. transplant) do not, generally, have greatly increased mortality from severe infection [29][30][31] , and the evidence of benefit of steroids in infections like COVID-19. 32 It is therefore possible that microbial load is not that relevant to outcomes in a relatively elderly cohort with bloodstream infection.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 93%

Time to positivity in bloodstream infection is not a prognostic marker for mortality: analysis of a prospective multicentre randomized control trial

Hamilton

Evans

Ghazal

et al. 2022

Clinical Microbiology and Infection

View full text Add to dashboard Cite

show abstract

“…When comparing the relative risk of pneumonia in this population with that in others, kidney transplant recipients are at much higher risk for hospitalization for pneumonia than the general population. This is illustrated in a study from Denmark that showed that the risk for first-time hospitalization for pneumonia was eightfold higher in kidney transplant recipients than in age-matched controls (2).…”

Section: Discussion Of Question 1amentioning

confidence: 99%

American Society of Nephrology Quiz and Questionnaire 2015: Transplantation

Josephson

Perazella

Choi

2016

CJASN

View full text Add to dashboard Cite

The Nephrology Quiz and Questionnaire remains an extremely popular session for attendees of the Annual Kidney Week Meeting of the American Society of Nephrology. Once again, the conference hall was overflowing with audience members and eager quiz participants. Topics covered by the expert discussants included electrolyte and acidbase disorders, glomerular disease, ESRD/dialysis, and kidney transplantation. Complex cases representing each of these categories along with single best answer questions were prepared and submitted by the panel of experts. Before the meeting, training program directors of US nephrology fellowship programs and nephrology fellows answered the questions through an internet-based questionnaire. During the live session, members of the audience tested their knowledge and judgment on a series of case-oriented questions prepared and discussed by the experts. They compared their answers in real time using their cell phones with a special application with the answers of the nephrology fellows and training program directors. The correct and incorrect answers were then discussed after the results of the questionnaire were displayed. As always, the audience, lecturers, and moderators enjoyed this highly educational session. This article recapitulates the session and reproduces its educational value for the Clinical Journal of the American Society of Nephrology readers. Enjoy the clinical cases and expert discussions.

show abstract

Risk and Prognosis of Hospitalization for Pneumonia Among Individuals With and Without Functioning Renal Transplants in Denmark: A Population-Based Study

Abstract: The risk of first-time hospitalization for pneumonia remains high among renal transplant candidates and recipients. The attributable morbidity and mortality are of great clinical and public health concern and preventive measures are warranted.

Cited by 17 publications

References 15 publications

Risk and outcome of pyelonephritis among renal transplant recipients

Risk and outcome of pyelonephritis among renal transplant recipients

Time to positivity in bloodstream infection is not a prognostic marker for mortality: analysis of a prospective multicentre randomized control trial

American Society of Nephrology Quiz and Questionnaire 2015: Transplantation

Contact Info

Product

Resources

About