Risk assessment and hygienic regulation of using of milbenock insecticide based on the new active substances aversectin class milbemectin

Abstract

Annotation. The problem of risk assessment for the population and persons involved in the treatment of agricultural crops with plant protection products is relevant in many countries of the world. The aim of the study was hygienic regulation of the Milbenok insecticide based on a new compound of the active substances aversectin class milbemectin to reduce the potential occupational risk and population risk. The method of natural experiment was used, residual amounts of milbemectin were determined by the method of high-performance liquid chromatography. Statistical processing of the obtained results, mathematical modeling of the degradation of the milbemectin was performed using EU recommendations and MS Excel programs (2000) and IBM SPSS Statistics Base v.22. It was determined that the half-life (DT50) of milbemectin in the soil in Ukraine climate regions – 21.4±1.6 days, in agricultural crops (apples, grapes) – 11.8±0.6 days. Risk assessment of the population based on the possible daily intake of the pesticide with products, as well as the integral indicator of danger when consuming products grown treated by insecticide Milbenok showed that the risk is two level lower than the permissible level and is moderately dangerous. The working zone is relatively safe for workers when using the insecticide. The risk for persons involved in the application of the Milbenok on apple trees, considering the contamination of personal protective equipment, was acceptable. The MRL of milbemectin was substantiated in apples, grapes (berries) – 0.02 mg/kg, apples, grapes (juice) – 0.01 mg/kg, AAC in the soil – 0.2 mg/kg and the regulations for the safe using of the Milbenok (pre harvest interval and time of workers' exit to cultivated areas). The obtained results should be considered when deciding the need to control pesticide residues in food products and environmental objects.