Risk Assessment and Management of Chemical Products

Hungerbühler, Konrad; Boucher, Justin M.; Pereira, Cecilia; Roiss, Thomas; Scheringer, Martin

doi:10.1007/978-3-030-62422-4_6

Cited by 1 publication

(1 citation statement)

References 47 publications

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“…These chemicals are used in a wide variety of industries, including food, medicine, clothes, and cosmetics, and they are manufactured and consumed in diverse consumer products (Sardar et al 2019). Concerns about their potential impacts on human health have risen in lockstep with the diversity of chemicals used in consumer products (Hungerbühler et al 2021). Therefore, toxicity studies are becoming more important because these chemicals can have direct and indirect negative effects on human health, as well as terrestrial and aquatic environments.…”

Section: Introductionmentioning

confidence: 99%

Proteomic analysis of zebrafish (Danio rerio) embryos exposed to benzyl benzoate

Kwon

Park

Lee

et al. 2022

Environ Sci Pollut Res

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Benzyl benzoate (BB) is widely used in the food, cosmetics, agriculture, and pharmaceutical industries and is discharged into the aquatic environment via various water sources, including wastewater. Research on the bioaccumulation and possible toxicity of BB has been conducted, but the biochemical responses to BB toxicity are not fully understood, and the specific molecular pathways by which BB causes toxicity remain unknown. In this study, label-free quantitative proteomics based on mass spectrometry was applied to investigate protein profiles in zebrafish (Danio rerio) embryos exposed to BB (1 µg/mL) for 7 days. A total of 83 differentially expressed proteins (DEPs) were identified, including 49 up-regulated and 34 down-regulated proteins. The biological functions of proteins regulated by BB were grouped into functional categories and subcategories, including the biosynthesis of organonitrogen compound biosynthetic process, translation, amide biosynthetic process, lipid transport, stress response, and cytoskeletal activity. The results provide novel insight into the molecular basis of the ecotoxicity of BB in aquatic ecosystems.

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Section: Introductionmentioning

confidence: 99%