Risk Assessment for Food Allergy

Crevel, René

doi:10.1002/9780470644584.ch15

Cited by 4 publications

(1 citation statement)

References 97 publications

(71 reference statements)

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“…3 Probabilistic approach in food allergen risk assessment (Crevel 2010;Kruizinga et al 2008;Spanjersberg et al 2007) proposing a single reference dose remains the biggest challenge. This can be seen from the individual studies proposing different ED values for multiple allergenic foods (Table 5).…”

Section: Probabilistic Modelmentioning

confidence: 99%

“May Contain” Allergen Statements: Facilitating or Frustrating Consumers?

Soon

Manning

2017

J Consum Policy

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As a result of mandatory labelling legislation, major food allergens that commonly cause allergic reactions are declared on packaging. The usage of precautionary allergen labelling (PAL) on packaging is not regulated in all countries, and the food industry uses various forms of "may contain" labelling which firstly is often inconsistent and secondly over time may diminish the value of such advisory statements. Hence, the aims of this paper are to review the current industry usage of PAL and to provide recommendations on future use that are of value to academics, policy makers, food industry, and consumers. A case study example is used to illustrate the likely costs and benefits of improving the current PAL status by considering a "peanut-free" product and calculation using the Voluntary Incidental Trace Allergen Labelling (VITAL) calculator. Governance such as addressing the inconsistent usage of PALs, promoting the harmonization of language used in PALs, and improving PAL status to quantified PAL statements would be helpful in communicating risks to consumers, so they can make informed choices when purchasing food products.

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Section: Probabilistic Modelmentioning

confidence: 99%

“May Contain” Allergen Statements: Facilitating or Frustrating Consumers?

Soon

Manning

2017

J Consum Policy

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Protein Allergy and GMOs

Ladics¹

2018

Comprehensive Toxicology

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Assessment of the potential allergenicity of genetically-engineered food crops

Ladics

2018

Journal of Immunotoxicology

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An extensive safety assessment process exists for genetically-engineered (GE) crops. The assessment includes an evaluation of the introduced protein as well as the crop containing the protein with the goal of demonstrating the GE crop is "as-safe-as" non-GE crops in the food supply. One of the evaluations for GE crops is to assess the expressed protein for allergenic potential. Currently, no single factor is recognized as a predictor for protein allergenicity. Therefore, a weight-of-the-evidence approach, which accounts for a variety of factors and approaches for an overall assessment of allergenic potential, is conducted. This assessment includes an evaluation of the history of exposure and safety of the gene(s) source; protein structure (e.g. amino acid sequence identity to human allergens); stability of the protein to pepsin digestion in vitro; heat stability of the protein; glycosylation status; and when appropriate, specific IgE binding studies with sera from relevant clinically allergic subjects. Since GE crops were first commercialized over 20 years ago, there is no proof that the introduced novel protein(s) in any commercialized GE food crop has caused food allergy.

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Risk Assessment for Food Allergy

Cited by 4 publications

References 97 publications

“May Contain” Allergen Statements: Facilitating or Frustrating Consumers?

“May Contain” Allergen Statements: Facilitating or Frustrating Consumers?

Protein Allergy and GMOs

Assessment of the potential allergenicity of genetically-engineered food crops

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