Risk assessment of occupational exposure to anesthesia Isoflurane in the hospital and veterinary settings

Pokhrel, Lok R.; Grady, Kisha D.

doi:10.1016/j.scitotenv.2021.146894

Cited by 10 publications

(11 citation statements)

References 49 publications

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“…First, we used OR employment history as a proxy for both surgical smoke exposure and disinfectant exposure and could not separate the roles of the 2 types of exposure in the analyses. Moreover, the results may have been affected by other related and competing respiratory irritants, such as formaldehyde and exhaled anesthesia such as isoflurane . Although we attempted to capture a gradient exposure to both sources of respiratory irritants, direct measures were not available.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the results may have been affected by other related and competing respiratory irritants, such as formaldehyde 51 and exhaled anesthesia such as isoflurane. 52 Although we attempted to capture a gradient exposure to both sources of respiratory irritants, direct measures were not available. Future studies should incorporate more detailed direct environmental monitoring data of multiple occupational exposures.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

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Association of Occupational Exposure to Inhaled Agents in Operating Rooms With Incidence of Chronic Obstructive Pulmonary Disease Among US Female Nurses

et al. 2021

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IMPORTANCE Employment in operating rooms (ORs) may involve exposure to several inhaled agents, including surgical smoke and disinfectants, which are associated with adverse respiratory health effects. However, the association of long-term employment in ORs and chronic obstructive pulmonary disease (COPD) remains unknown. OBJECTIVE To examine the association of working in an OR with incidence of COPD among female nurses in the US. DESIGN, SETTING, AND PARTICIPANTS This cohort study used data from the Nurses' Health Study for US female registered nurses who provided information on questionnaires regarding OR

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Section: Discussionmentioning

confidence: 99%

Section: Strengths and Limitationsmentioning

confidence: 99%

Association of Occupational Exposure to Inhaled Agents in Operating Rooms With Incidence of Chronic Obstructive Pulmonary Disease Among US Female Nurses

et al. 2021

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“…Considering that exposure to isoflurane in the workplace is inevitable, several professionals from medical and veterinary fields have occupational exposure. In fact, there is concern about isoflurane toxicity in exposed professionals (Pokhrel & Grady, 2021). In addition, anesthetic exposure is an important risk factor for reproductive issues in veterinarians who work long hours in operating rooms without an active scavenging system (Oliveira et al, 2021; Shirangi et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Veterinarians exposed to inhaled anesthetic present chromosome damage, apoptosis and cell cycle changes

Braz,

Figueiredo,

Golim

et al. 2024

Environ and Mol Mutagen

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This cross‐sectional study evaluated, for the first time, DNA damage, viability, and cell death of lymphocytes and cell cycle phases of mononuclear and polymorphonuclear cells in veterinarians exposed to the volatile anesthetic isoflurane. Veterinarians who were occupationally exposed to isoflurane (exposed group; n = 20) and matched‐unexposed individuals (volunteers without occupational exposure; n = 20) were enrolled in the study. DNA damage was assessed in lymphocytes by micronucleus (MN) and phosphorylated histone gamma‐H2AX (γ‐H2AX). Cell viability, cytotoxicity, and the cell cycle were evaluated by flow cytometry. Isoflurane was detected in urine samples by headspace gas chromatography–mass spectrometry. Compared with unexposed subjects, veterinarians occupationally exposed to isoflurane (25.7 ± 23.7 μg/L urine) presented statistically higher MN frequencies, lymphocytic apoptosis rates, and numbers of polymorphonuclear cells in the G0/G1 stage. Additionally, the exposed group presented statistically lower proportions of viable lymphocytes and G2/M polymorphonuclear cells. Our findings indicate that veterinarians who are frequently exposed to inhaled anesthetic exhibit chromosomal and cell damage in addition to changes in peripheral blood cell proliferation.

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“…According to the World Organization for Occupational Safety and Health (OSHA), more than 250,000 hospital staff in the United States are exposed to these gases and are at risk (12).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Milk Thistle, Green Tea, and Cinnamon Beverages on Liver Enzymes of Operating Room Anesthesia Personnel

Kheirandish,

Mard-Soltani,

Mojab

et al. 2023

Trends Med Sci

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Background: Millions of health workers in operating rooms worldwide are exposed to inhaled anesthetics. However, the effects of continuous exposure to inhalational anesthetics are still controversial in many studies. Objectives: The present study investigated the effects of milk thistle, green tea, and cinnamon consumption on liver enzymes in operating room personnel. Methods: In this study, we investigated the effects of milk thistle tea, green tea, and cinnamon tea on liver enzymes in operating room staff in a controlled, double-blind study from 2019 to 2020. In two parallel groups, 62 subjects were randomly assigned to ingest the beverages the teas. Milk thistle, green tea, and cinnamon were taken daily for four weeks. During the intervention, all participants were educated about the importance of a balanced diet and physical activity. Results: The milk thistle, green tea, and cinnamon groups showed a significant statistical difference in reduced levels of AST, ALT, ALP, ALB, GGT, bilirubin, and ESR after four weeks (P value < 0.001). Conclusions: The results of this study demonstrated that ingesting green tea and cinnamon reduced liver enzymes in surgical personnel. Among the extracts, milk thistle had a greater effect on liver enzymes than the other two extracts. It can be concluded that the prescribed milk thistle extract can be considered a potential intervention to improve liver enzyme levels in surgical personnel to reduce the adverse effects of anesthetics.

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Risk assessment of occupational exposure to anesthesia Isoflurane in the hospital and veterinary settings

Cited by 10 publications

References 49 publications

Association of Occupational Exposure to Inhaled Agents in Operating Rooms With Incidence of Chronic Obstructive Pulmonary Disease Among US Female Nurses

Association of Occupational Exposure to Inhaled Agents in Operating Rooms With Incidence of Chronic Obstructive Pulmonary Disease Among US Female Nurses

Veterinarians exposed to inhaled anesthetic present chromosome damage, apoptosis and cell cycle changes

The Effect of Milk Thistle, Green Tea, and Cinnamon Beverages on Liver Enzymes of Operating Room Anesthesia Personnel

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