Risk assessment of phthalates in pharmaceuticals

Chung, Bu Young; Choi, Seul Min; Roh, Taehyun; Lim, Duck Soo; Ahn, Mi Young; Kim, Yeon Joo; Kim, Hyung Sik; Lee, Byung Mu

doi:10.1080/15287394.2019.1598053

Cited by 38 publications

(15 citation statements)

References 28 publications

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“…We found significantly higher levels of OH-MiBP in women who used pharmaceuticals. Many studies showed that pharmaceuticals could be a source of phthalate exposure [39,40]. When we analysed the specific type of pharmaceuticals-hormonal therapy-we found surprisingly higher levels of MnBP, OH-MEHP, and oxo-MEHP in women who did not use hormonal therapy, which is in disagreement with the studies of Al Saleh et al [41,42], who observed increased phthalate metabolite concentrations in probands undergoing in vitro fertilisation [41], and women with contraceptive-use history [42].…”

Section: Analysis Of Maternal Baseline Characteristics In Association...contrasting

confidence: 82%

Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns

et al. 2022

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Adverse birth outcomes present risk factors resulting in neonatal morbidity and mortality. Sufficient maternal hormonal concentrations are crucial for normal foetal development. Previous studies have shown a relationship between phthalate exposure and maternal hormonal levels during pregnancy. This study aims to investigate if neonatal anthropometric parameters are associated with maternal endocrine parameters during the ≤15th week of gestation and the third trimester of pregnancy concerning phthalate exposure in pregnant women from Nitra, Slovakia. We used high-performance liquid chromatography, tandem mass spectrometry (HPLC-MS/MS), and electro-chemiluminescence immunoassay to quantify urinary concentrations of phthalates and serum concentrations of hormones and sex hormone-binding globulin (SHBG), respectively. We observed a mostly positive correlation between neonatal anthropometric parameters (gestational age, birth length, birth weight, head circumference) and maternal concentration of phthalate metabolites (p ≤ 0.05). The hierarchical multivariate regression results showed a statistically significant association between Apgar score at 5 min after delivery, gestational age, birth weight, head circumference, and maternal endocrine parameters during pregnancy (p ≤ 0.05), adjusted to phthalate metabolites. To the best of our knowledge, our study is the first to indicate that prenatal exposure to phthalates may also affect birth outcomes through interaction with the maternal endocrine system.

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Section: Analysis Of Maternal Baseline Characteristics In Association...contrasting

confidence: 82%

Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns

et al. 2022

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“…Moreover, we have to discuss that we did not detect sex-specific effects; however, when conducting separate analyses for men and women, our study was not enough powered, so no sex-specific consideration can be deducted from our work. We are also aware that some oral drugs may contain phthalates and that their level might vary a lot between different medications [ 20 , 21 ]. We do not investigate any association with specific medicines due to their extreme variety compared to the small, simple size.…”

Section: Discussionmentioning

confidence: 99%

“…While some studies have reported the association of phthalates’ levels with bad oral health [ 19 ], no studies have, so far, explored the potential association between phthalates and edentulism, nor their relative contribution to CV risk and other cardiometabolic health’s determinants, as body mass index (BMI) and glucose control. Several observations have described the presence of phthalates in some orally administered drugs [ 20 , 21 ], further exposing the oral cavity to their potentially harmful effect. Phthalates have been found in personal oral care products [ 22 ] and in drug delivery systems for periodontitis treatment [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

High exposure to phthalates is associated with HbA1c worsening in type 2 diabetes subjects with and without edentulism: a prospective pilot study

Mengozzi

Carli

Pezzica

et al. 2022

Diabetol Metab Syndr

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Background Phthalates exposure and complete edentulism are related to both low socioeconomic status. No study by far has verified if and to what extent these two conditions are related. We aimed to explore their potential association and interplay in the metabolic control and cardiovascular risk profile. Methods In our small (n = 48) prospective pilot study twenty-four patients with type 2 diabetes (DnE) and twenty-four patients with type 2 diabetes and edentulism (DE) followed for 19 ± 2 months were treated according to best clinical standards. Phthalates’ exposure was evaluated by urinary concentration of di-2-ethylhexylphthalate (DEHP), metabolites, i.e. mono 2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-oxohexyl phthalate (MEOHP) and mono 2-ethyl-5-hydroxyhexyl phthalate (MEHHP). Results No association between phthalates and edentulism was found, nor did edentulism affect glucose control. Higher phthalates exposure was associated with a glycated haemoglobin worsening. This association was found for all the measured phthalates metabolites, both as a whole (DEHP; r = 0.33, p = 0.0209) and individually: MEHP (r = 0.41, p = 0.0033), MEHHP (r = 0.32, p = 0.028), MEOHP (r = 0.28, p = 0.0386). Conclusions Phthalates are not associated with edentulism but predict the worsening of glucose control in subjects with type 2 diabetes. These findings might prove relevant in identifying novel biomarkers of cardiometabolic risk. Further studies are needed to validate our results and estimate the true potential of phthalates in terms of risk assessment.

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“…El revestimiento entérico brinda varias ventajas a estos productos, uno de ellos es la resistencia a la digestión gástrica o la degradación del fármaco antes de llegar al intestino y en otros casos va muy relacionado con la velocidad de absorción del principio activo. Como este, existen otros fármacos (Videx EC, Creon, entre otros) con compuestos ftálicos en su composición que pueden cumplir las funciones de excipientes, saborizantes artificiales o como revestimiento entérico [32].…”

Section: Clasificación Y Fuentes De Mpsunclassified

Microplastics: A Contaminant That Grows in All Environmental Areas, Its Characteristics and Possible Risks to Public Health From Exposure

Castañeta¹,

n²,

Gutiérrez³

et al. 2020

Rev. Bol. Quim.

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Los microplásticos (MPs) se han convertido en un desafío importante para las ciencias ambientales, química analítica y toxicología ambiental en los últimos años. Estos han atraído la atención mundial en su categoría de contaminantes emergentes debido a sus interacciones y persistencia en el medioambiente, además de su origen a partir de una deficiente gestión en el tratamiento de los residuos de centros urbanos, además de malas prácticas industriales y su uso indiscriminado. Los MPs actualmente están dispersos por todas partes del planeta, desde los océanos hasta los ríos, sedimentos, suelo, aire, organismos vivos e incluso en los recursos alimenticios y zonas remotas del planeta como el ártico y glaciares montañosos. Por lo tanto, esta revisión tiene como objetivo el informar acerca de la formación, tipos, fuentes, interacción con contaminantes y posibles consecuencias en la salud por los MPs presentes en el medioambiente. Buscamos concientizar de que en la actualidad se está viviendo junto a los MPs sin darnos cuenta. Además, esta revisión también incluye un breve recorrido por los últimos estudios que se han realizado en Sudamérica, conceptualizando la realidad local y regional con respecto a este problema de carácter global

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Risk assessment of phthalates in pharmaceuticals

Cited by 38 publications

References 28 publications

Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns

Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns

High exposure to phthalates is associated with HbA1c worsening in type 2 diabetes subjects with and without edentulism: a prospective pilot study

Microplastics: A Contaminant That Grows in All Environmental Areas, Its Characteristics and Possible Risks to Public Health From Exposure

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