The difference method is not rooted in the mathematical definition of EVPI and is clearly an inappropriate method for estimating EVPPI. The single MCS and UNLI methods were the least complex methods to use, but are restricted in their appropriateness. The two-stage MCS and quadrature-based methods are complex and time consuming. Thus, where appropriate, EVPPI should be estimated using either the single MCS or UNLI method. However, where neither of these methods is appropriate, either of the two-stage MCS and quadrature methods should be used.