2006
DOI: 10.1002/ijc.22134
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Risk‐based selection from the general population in a screening trial: Selection criteria, recruitment and power for the Dutch‐Belgian randomised lung cancer multi‐slice CT screening trial (NELSON)

Abstract: A method to obtain the optimal selection criteria, taking into account available resources and capacity and the impact on power, is presented for the Dutch-Belgian randomised lung cancer screening trial (NELSON). NELSON investigates whether 16-detector multi-slice computed tomography screening will decrease lung cancer mortality compared to no screening. A questionnaire was sent to 335,441 (mainly) men, aged 50-75. Smoking exposure (years smoked, cigarettes/day, years quit) was determined, and expected lung ca… Show more

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Cited by 442 publications
(372 citation statements)
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“…Preliminary data from four randomized controlled trials (RCTs) using CT screening in the intervention arm have been published (16)(17)(18)(19)(20)(21). Three of these trials were conducted in advance of large multi-center national trials to determine the feasibility of enrollment into a randomized trial by generalists (16)(17)(18).…”
Section: Findings From Preliminary Randomized Controlled Trialsmentioning
confidence: 99%
See 1 more Smart Citation
“…Preliminary data from four randomized controlled trials (RCTs) using CT screening in the intervention arm have been published (16)(17)(18)(19)(20)(21). Three of these trials were conducted in advance of large multi-center national trials to determine the feasibility of enrollment into a randomized trial by generalists (16)(17)(18).…”
Section: Findings From Preliminary Randomized Controlled Trialsmentioning
confidence: 99%
“…In 2003, the NELSON trial was launched, a Dutch-Belgian trial that randomized roughly 16,000 high risk participants to receive either annual CT screening (at years 1, 2 and 4) versus a control arm receiving no screening (19,20). The NELSON is the only trial in which the control arm receives no screening intervention, and has 80% power to show a lung cancer mortality reduction of at least 25% by 10 years after randomization.…”
Section: Findings From Preliminary Randomized Controlled Trialsmentioning
confidence: 99%
“…Participants were current and former heavy smokers, aged 50-75 years. Recruitment procedures and selection criteria in the NELSON trial have been published [13]. In total, 15,822 individuals were randomised to no screening (N=7,907) or screening (N= 7,915) by low-dose chest CT at baseline (1st round), 1 year later (2nd round), 3 years later (3rd round) and 5.5 years later (4th round), and extra low-dose follow-up CT examinations in case of an indeterminate screening result [14] (Fig.…”
Section: Study Populationmentioning
confidence: 99%
“…2,3 In a published study analyzing Surveillance, Epidemiology, and End Results (SEER) data, of all 316,882 patients with lung cancer, 45,912 patients (14%) were 80 years of age, 33% were 70-79 years of age, and 53% were <70 years of age. 2 In addition, with the anticipated increase in detection of lung cancer via computed tomography (CT) screenings, [4][5][6] an even greater number of elderly patients may be diagnosed with early-stage lung cancer.…”
Section: Introductionmentioning
confidence: 99%