2021
DOI: 10.3390/jcm10102214
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Risk Categories in COVID-19 Based on Degrees of Inflammation: Data on More Than 17,000 Patients from the Spanish SEMI-COVID-19 Registry

Abstract: (1) Background: The inflammation or cytokine storm that accompanies COVID-19 marks the prognosis. This study aimed to identify three risk categories based on inflammatory parameters on admission. (2) Methods: Retrospective cohort study of patients diagnosed with COVID-19, collected and followed-up from 1 March to 31 July 2020, from the nationwide Spanish SEMI-COVID-19 Registry. The three categories of low, intermediate, and high risk were determined by taking into consideration the terciles of the total lympho… Show more

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Cited by 18 publications
(19 citation statements)
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“…From March 1st, 2020 to May 1st, 2021, 21,962 hospitalized patients were included in the Registry. Methods of the study have been previously described [ 10 ]. In brief, all included patients were diagnosed by polymerase chain reaction (PCR) test or rapid antigenic test for SARS-CoV-2 taken from a nasopharyngeal sample, sputum, or bronchoalveolar lavage.…”
Section: Methodsmentioning
confidence: 99%
See 2 more Smart Citations
“…From March 1st, 2020 to May 1st, 2021, 21,962 hospitalized patients were included in the Registry. Methods of the study have been previously described [ 10 ]. In brief, all included patients were diagnosed by polymerase chain reaction (PCR) test or rapid antigenic test for SARS-CoV-2 taken from a nasopharyngeal sample, sputum, or bronchoalveolar lavage.…”
Section: Methodsmentioning
confidence: 99%
“…The treatments received were in accordance with the medical guidelines available at the time of the pandemic [ 10 ]. In the absence of clinical evidence of any of the treatments at the initial time of the pandemic, their use was allowed off-label.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The inclusion criteria were all patients in the registry with a community (non-nosocomial) SARS-CoV-2 infection and belonging to the high-risk category of inflammation according to our previous report and based on the lab test on admission [4]. This category of high risk is based on the decrease in the lymphocyte count 101.5 mg/L, lactate dehydrogenase (LDH) > 394U/L, ferritin > 1359.9mcg/L, and D-dimer > 1580 ng/mL.…”
Section: Study Design Patient Selection and Data Collectionmentioning
confidence: 99%
“…Why some patients become more inflamed than others is not known for certain but it is possible that there is a genetic background that facilitates this. Among those patients who present with this exaggerated inflammatory response, different degrees of inflammation have been described that predict the short-term future of these patients [4]. However, this inflammation is far from being homogeneous in all patients.…”
Section: Introductionmentioning
confidence: 99%