Risk due to exposure to metallic elements in a birdshot factory

Lovreglio, Piero; Filippis, Giovanni De; Tamborrino, Brizio; Drago, Ignazio; Rotondi, Rossana; Gallone, Annamaria; Paganelli, Matteo; Apostoli, Pietro; Soleo, Leonardo

doi:10.1080/19338244.2017.1322934

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…It is hypothesized that Cd reaches the prostate by mimicking certain hormones, but more studies are required [40]. Studies have found a correlation between air cadmium and blood cadmium and DNA damage [41,42], further suggesting the importance of air cadmium. Most of the literature addresses the biological effect of cadmium on the initiation and promotion of PC, with little attention to progression (an increase in genomic instability, tumor growth and metastasis) of already established malignancy.…”

Section: Discussionmentioning

confidence: 99%

Observational Study of the Association between Air Cadmium Exposure and Prostate Cancer Aggressiveness at Diagnosis among a Nationwide Retrospective Cohort of 230,540 Patients in the United States

Vijayakumar

Abern

Jagai

et al. 2021

IJERPH

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Although studies have investigated cadmium and prostate cancer (PC) incidence and mortality, the role of cadmium in PC progression might be more clinically relevant. In this observational study, we assessed the association between air cadmium exposure and PC aggressiveness, with PC stage defined as metastatic or localized and Gleason grade defined as high (Gleason score ≥ 8) or low (Gleason score ≤ 6) among PC patients from the 2010–2014 US Surveillance, Epidemiology, and End Results database. The 2005 and 2011 National Air Toxics Assessment provided county-level air cadmium concentrations. Results were presented as odds ratios (OR) with 95% confidence intervals (CI) and were calculated using random intercept mixed effects logistic regression, comparing the 80th to 20th percentile of exposure. We adjusted for age, sociodemographic status, smoking prevalence, and overall air quality at the county level, and stratified by race, age, and degree of urbanization. The cohort consisted of 230,540 cases from 493 counties. Strong associations were observed in nonmetropolitan, urban areas: (OR 1.26, CI 1.14–1.39) for metastatic vs. localized and (OR 1.41, CI 1.27–1.57) for high- vs. low-grade PC where 40 million Americans reside. This study may be hypothesis-generating to inform future studies and public health measures.

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Section: Discussionmentioning

confidence: 99%

Observational Study of the Association between Air Cadmium Exposure and Prostate Cancer Aggressiveness at Diagnosis among a Nationwide Retrospective Cohort of 230,540 Patients in the United States

Vijayakumar

Abern

Jagai

et al. 2021

IJERPH

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“…In addition to Vitamin B 12 and folate, the kidney also metabolizes Hc; elevated blood levels of Hc have been found in patients with kidney disease [80,81]. Although the pathogenesis of hHc in renal disease is still unknown, both in vivo and in vitro studies have suggested that the kidney plays a fundamental role in Hc metabolism [81,82]. Data from previous studies show that high blood Hc values in patients with renal disease are related to the reduction of Hc clearance from the body due to metabolic accumulation [83,84].…”

Section: Chromium (Cr)mentioning

confidence: 99%

Exposure to Toxic Heavy Metals Can Influence Homocysteine Metabolism?

et al. 2019

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Background: Homocysteine is a sulfur amino acid whose metabolism is activated in two pathways: remethylation to methionine, which requires folate and vitamin B 12 , and transsulfuration to cystathionine, which needs pyridoxal-5'-phosphate. High homocysteine level increases the risk of developing heart disease, stroke, peripheral vascular diseases, and cognitive impairment. Some evidence showed that exposure to these metals increased plasma homocysteine levels. Methods: A systematic review was carried out to clarify the relationship between homocysteine blood levels and exposure to toxic heavy metals (Lead, Cadmium, Mercury, and Chromium). Results: The results of this systematic review indicate that exposure to Pb, Cr, Cd, and Hg is connected with nonphysiological homocysteine levels or vitamin B 12 and folate serum concentrations. Conclusions: These findings reinforce the importance of involvement in exposure to heavy metals in homocysteine metabolism. This supports the role of blood metals as potential upstream modifiable risk factors to prevent the development of other established risk factors as hyperhomocysteinemia.

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“…Antimony (Sb) and its compounds are widely used in some industries, including alloy, plastic, glass, and textile industries [ 1 , 2 , 3 , 4 , 5 , 6 ]. The permissible exposure limit (PEL) established by the US Occupational Safety and Health Administration for exposure to antimony and compounds is 0.5 mg/m 3 of antimony in the workplace based on a working 8 h shift and a 40 h week [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Industrial Antimony Exposure and Immunologic Function for Workers in Taiwan

Chen

2017

IJERPH

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This study investigated antimony exposure among employees in industries in Taiwan and evaluated whether their immunologic markers were associated with antimony exposure. We recruited 91 male workers and 42 male office administrators from 2 glass manufacturing plants, 1 antimony trioxide manufacturing plants, and 2 engineering plastic manufacturing plants. Air samples were collected at worksites and administrative offices, and each participant provided specimens of urine, blood, and hair to assay antimony levels. We also determined white blood cells, lymphocyte, and monocyte, IgA, IgE, and IgG in blood specimens. The mean antimony concentration in the air measured at worksites was much higher in the antimony trioxide plant (2.51 ± 0.57 mg/m3) than in plastic plants (0.21 ± 0.06 mg/m3) and glass plants (0.14 ± 0.01 mg/m3). Antimony levels in blood, urine, and hair measured for participants were correlated with worksites and were higher in workers than in administrators. The mean serum IgG, IgA, and IgE levels were lower in workers than in administrators (p < 0.001). Serum IgA and IgE levels in participants were negatively associated with antimony levels in air samples of workplaces, and in blood, urine, and hairs of participants. Serum IgG and IgE of all participants were also negatively associated with antimony levels in their hairs. In conclusion, the antimony exposure is greater for workers employed in the five industrial plants than for administrators. This study suggests serum IgG, IgA, and IgE levels are negatively associated with antimony exposure.

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Risk due to exposure to metallic elements in a birdshot factory

Cited by 3 publications

References 11 publications

Observational Study of the Association between Air Cadmium Exposure and Prostate Cancer Aggressiveness at Diagnosis among a Nationwide Retrospective Cohort of 230,540 Patients in the United States

Observational Study of the Association between Air Cadmium Exposure and Prostate Cancer Aggressiveness at Diagnosis among a Nationwide Retrospective Cohort of 230,540 Patients in the United States

Exposure to Toxic Heavy Metals Can Influence Homocysteine Metabolism?

Assessment of Industrial Antimony Exposure and Immunologic Function for Workers in Taiwan

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