2012
DOI: 10.3233/jad-2012-129040
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Risk Estimations, Risk Factors, and Genetic Variants Associated with Alzheimer's Disease in Selected Publications from the Framingham Heart Study

Abstract: The study of Alzheimer Disease (AD) in the Framingham Heart Study (FHS), a multi-generational, community-based population study, began nearly four decades ago. In this overview, we highlight findings from 7 prior publications that examined lifetime risk estimates for AD, environmental risk factors for AD, circulating and imaging markers of aging-related brain injury and explorations on the genetics underlying AD.

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Cited by 22 publications
(19 citation statements)
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“…This suggests that even though different life event assessments were used, the data gave consistent and thus reliable results across all cohorts. Because we were not necessarily interested in the physiological effect of health problems on dementia incidence, we adjusted for blood pressure, BMI, diabetes mellitus and coronary heart disease in the analyses, as vascular risk factors and diseases are the most frequent health-related risk factors for dementia(42). By pooling each study’s results into a meta-analysis our results may generalize further to other studies, as usually many different measures of psychosocial stress are used.…”
Section: Discussionmentioning
confidence: 99%
“…This suggests that even though different life event assessments were used, the data gave consistent and thus reliable results across all cohorts. Because we were not necessarily interested in the physiological effect of health problems on dementia incidence, we adjusted for blood pressure, BMI, diabetes mellitus and coronary heart disease in the analyses, as vascular risk factors and diseases are the most frequent health-related risk factors for dementia(42). By pooling each study’s results into a meta-analysis our results may generalize further to other studies, as usually many different measures of psychosocial stress are used.…”
Section: Discussionmentioning
confidence: 99%
“…The implication from these studies and reviews is that overlapping trauma-induced neurodegenerative effects occur within the same frontotemporolimbic areas associated with age-related neurodegenerative disorders. This association between TBI and later onset of dementia may also relate to the selective WM damage that occurs with TBI and the role that WM pathology plays in the expression of dementia via a breakdown in neural connectivity and networks (Carmichael and Salloway, 2012; Shively et al, 2012; Weinstein et al, 2013). …”
Section: Aging Tbi and Neurodegenerative Disordersmentioning
confidence: 99%
“…The common risk factors, such as apolipoprotein E, age, smoking, inflammation, and body metabolism, do not fully explain the increased atheromatous plaque occurrence in severe AD, rather than in early AD patients 2,4,5,20–23. We believe it is possible that the neuronal death and neuroinflammation in late-stage AD triggered the atheromatous plaque formation.…”
Section: Discussionmentioning
confidence: 99%