Risk Factor Analysis of Pan-drug Resistant Acinetobacter baumannii-induced Ventilator-associated Pneumonia in ICU

Abstract

Zheng et al.: Drug resistant bacteria-induced ventilator-associated pneumoniaThis study was to investigate the risk factors of ventilator-associated pneumonia caused by pan-drug resistant Acinetobacter baumannii in intensive care unit so as to provide related basis for clinical prevention. A total of 105 intensive care unit patients, who were treated with ventilator over 48 h in the First Affiliated Hospital of Anhui Medical University and developed Acinetobacter baumannii-induced ventilator-associated pneumonia from January to September 2017 were enrolled in this study, including 70 cases with pan-drug resistant Acinetobacter baumannii infection served as the pan-drug resistant group and 35 cases with nonpan-drug resistant Acinetobacter baumannii infection served as the control group. The univariate analysis and logistic regression method were used to explore the risk factors of ventilator-associated pneumonia caused by pan-drug resistant Acinetobacter baumannii. The result of univariate analysis showed that the risk factors of pan-drug resistant Acinetobacter baumannii-induced ventilator-associated pneumonia included tracheotomy, enteral nutrition, the use of carbapenems and use of more than 3 antibiotics before infection. Logistic regression analysis showed that enteral nutrition and the use of carbapenems were independent risk factors of pan-drug resistant Acinetobacter baumannii-induced ventilator-associated pneumonia. In conclusion, enteral malnutrition and the use of carbapenems were the two significant risk factors for pandrug resistant Acinetobacter baumannii-induced ventilator-associated pneumonia, which are necessary to take active preventive measures in clinical practice.

Prevalence of Acinetobacter baumannii with multiple drug resistance isolated from patients with ventilator-associated pneumonia from 2010 to 2020 in the world: a systematic review and meta-analysis

“…The highest prevalence rates of A. baumannii isolated from patients with VAP were observed in Zeng et al 1.00 (95% CI: 0.97−1.00) [18], Attia and Elbaradei 1.00 (95% CI: 0.84−1.00) [21], Asadian et al 1.00 (95% CI: 0.89−1.00) [22], Li et al 1.00 (95% CI: 0.93−1.00) [23], Nowak et al 1.00 (95% CI: 0.94−1.00) [24], Brotfain et al 1.00 (95% CI: 0.99−1.00) [25], Bianco et al 1.00 (95% CI: 0.63−1.00) [26], Zalts et al 1.00 (95% CI: 0.96−1.00) [27], Inchai et al 1.00 (95% CI: 0.99−1.00) [28], and Ozgur et al 1.00 (95% CI: 0.97−1.00) [29].…”

“…The highest and lowest prevalence rates of PDR A. baumannii isolated from patients with VAP were observed in the studies conducted by Zeng et al (0.67; 95% CI: 0.57−0.76) [18] and Adukauskienė and Čiginskienė (0.18; 95% CI: 0.10−0.29) [35], respectively. The combined prevalence of PDR A. baumannii isolated from patients with VAP was reported to be 0.40 (95% CI: 0.28−0.52) (Fig.…”

“…Prevalence of pan drug-resistant A. baumannii isolated from patients with ventilator-associated pneumonia The highest and lowest prevalence rates of PDR A. baumannii isolated from patients with VAP were observed in the studies conducted by Zeng et al (0.67; 95% CI: 0.57À0.76) [18] and Adukauskien¼ : and C ˇiginskien¼ :…”