Risk factors analysis of attention deficit/hyperactivity disorder and allergic rhinitis in children: a cross-sectional study

Chen, Keyang; Zheng, Xiuxiu; Li, Ziyue; Xiang, Haijie; Chen, Bobei; Zhang, Hui

doi:10.1186/s13052-019-0703-1

Cited by 16 publications

(26 citation statements)

References 36 publications

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“…Disturbances to sleep can lead to abnormal functioning of various brain circuits, including the prefrontal cortex, which in turn influences behavior and cognitive operations ( 103 ). Executive functioning is usually defective in ADHD, and hence, poor sleep quality may collectively enhance the probability of developing symptoms of ADHD in patients with allergic diseases ( 104 ). Similarly, a study by Mazurek et al highlighted a significant link between behavioral problems in ASD children and poor sleep ( 105 ).…”

Section: Common Factors Implicated In Both Allergic Diseases and Neurmentioning

confidence: 99%

Understanding the Link Between Allergy and Neurodevelopmental Disorders: A Current Review of Factors and Mechanisms

et al. 2021

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Both allergic diseases and neurodevelopmental disorders are non-communicable diseases (NCDs) that not only impact on the quality of life and but also result in substantial economic burden. Immune dysregulation and inflammation are typical hallmarks in both allergic and neurodevelopmental disorders, suggesting converging pathophysiology. Epidemiological studies provided convincing evidence for the link between allergy and neurodevelopmental diseases such as attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Possible factors influencing the development of these disorders include maternal depression and anxiety, gestational diabetes mellitus, maternal allergic status, diet, exposure to environmental pollutants, microbiome dysbiosis, and sleep disturbances that occur early in life. Moreover, apart from inflammation, epigenetics, gene expression, and mitochondrial dysfunction have emerged as possible underlying mechanisms in the pathogenesis of these conditions. The exploration and understanding of these shared factors and possible mechanisms may enable us to elucidate the link in the comorbidity.

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Section: Common Factors Implicated In Both Allergic Diseases and Neurmentioning

confidence: 99%

Understanding the Link Between Allergy and Neurodevelopmental Disorders: A Current Review of Factors and Mechanisms

et al. 2021

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“…Moreover, recent studies have proposed that pediatric allergic airway disease was associated with declines in cognitive function and school attendance (Yamasaki et al, 2020). As for attention deficits, AR is also reported to be closely related to attention-deficit hyperactivity disorder (ADHD) in previous studies (Brawley et al, 2004;Melamed and Heffron, 2016;Yang et al, 2016;Feng et al, 2017;Miyazaki et al, 2017;Wang et al, 2018;Chen et al, 2019;Guo et al, 2020). Children with ADHD were found to be more likely to have AR than are their counterparts (Miyazaki et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Changes in Resting-State Spontaneous Brain Activity in Patients With Allergic Rhinitis: A Pilot Neuroimaging Study

et al. 2021

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BackgroundAllergic rhinitis (AR) is an inflammatory disorder of the nose caused by immunoglobulin E (IgE)-mediated immune response to allergens. Apart from the typical symptoms of sneezing, itching, rhinorrhea, and nasal congestion, behavioral complications were also reported to be associated with the progression of AR, such as cognitive deficits, mood changes, memory decline, attention deficiency, poor school performance, anxiety, and depression. Recent human studies have suggested that alterations in brain function caused by allergen exposure may precipitate high levels of anxiety and emotional reactivity in asthma patients. But until now, there is no direct evidence of the relationship between brain activity and allergic rhinitis.MethodsResting-state functional magnetic resonance imaging (rs-fMRI) was used to excavate whether there remain functional changes of brain activity in AR patients. We measured the amplitude of low-frequency fluctuation (ALFF) and the z conversion of ALFF (zALFF) in 20 patients with AR and 20 age- and sex-matched healthy controls (HCs) using the rs-fMRI data.ResultsCompared with healthy controls, AR patients exhibited lower ALFF values in the precuneus (PCUN) and higher ALFF values in the anterior cingulate cortex (ACC). The ALFF values of these features were significantly correlated with the visual analog scale (VAS) scores, the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) scores, the subscales of RQLQ, and specific IgE, partly.ConclusionWe found changes in resting-state spontaneous brain activity in AR patients with hypoactivity in the PCUN and hyperactivity of the ACC. The brain-related symptoms of AR might be another potential clinical intervention target for improving the life quality of AR patients. Further attention to brain activity is essential for a deeper understanding of AR.

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“…Inflammatory cytokines can activate neuroimmune mechanisms that involve brain circuits that affect behavior and emotions, and indirectly influence neuronal activity of brain structures through activation of hypothalamic-pituitary-adrenal pathway. In addition, inflammatory cytokines will also disrupt the metabolism of central neurotransmitters such as norepinephrine and dopamine which are known to play a role in the pathology of ADHD 18 .…”

Section: Figure 2 Immune Dysregulation Effect To Behaviormentioning

confidence: 99%

“…The mechanism of allergic rhinitis comorbidity with ADHD, is also thought to be due to stress exposure at an early age of child. Stress is related to the development of typical brain structure of ADHD, which affects cognitive function, and leads to onset of ADHD symptoms 18 .…”

Section: Figure 2 Immune Dysregulation Effect To Behaviormentioning

confidence: 99%

“…In addition, allergic diseases and ADHD are thought to have similar genetic mechanisms. Signal transducers and activators of tranion 6 (STAT6) are involved in immune system regulation, cell proliferation, and apoptosis, which are thought to play a role in the pathogenesis of ADHD, and closely related to allergic diseases 18 .…”

Section: Figure 2 Immune Dysregulation Effect To Behaviormentioning

confidence: 99%

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Immunotherapy Duration and Risk of Psychosocial Emotion and Risk of Attention Deficit Hyperactivity Disorder Prevalence and Relation in Allergic Rhinitis Children

Tunjungsari¹,

Endaryanto²,

Suryawan³

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Background: Allergic rhinitis (AR) is the most common chronic disease in children. Allergic symptoms affect daily activities and increase risk of psychosocial emotion and attention deficit hyperactivity disorder (ADHD). Immunotherapy has been proven in improving AR symptoms Objective: To identify prevalence of the risk of psychosocial emotion disorder and ADHD and its relation with immunotherapy duration in AR children. Methods:A cross-sectional study was held in AR children aged 4-18 years at Allergy Immunology Outpatient Clinic, Dr. Soetomo Hospital, during March 2017. Immunotherapy duration categorized into 0-6 months, 6 months-1 year, 1-2 years, 2-3 years. Psychosocial emotion disorder risk assessed using Pediatric Symptoms Checklist 17 (PSC-17), scored into four different subscales: Internalizing, Externalizing, Attention, and Total Score. ADHD risk was assessed using Abbreviated Conner's Rating Scale (ACRS). Statistical analysis using One-Way ANOVA and Eta test, with a value of p< 0.05 considered as significant.Results: Total of 37 children included. Based on immunotherapy duration 0-6 months, 6 months-1 year, 1-2 years, and 2-3 years, prevalence risk of ADHD are 20.6%, 15.4%, 12.5%, and 12.5%, and prevalence of psychosocial emotion disorder risk are only in immunotherapy duration 6 months-1 year 12.5%. There were no correlation between immunotherapy duration with risk of psychosocial emotion disorder (p = 0.945) and significantly correlated to ADHD (p = 0.049, r = 0.326). Conclusion:Prevalence risk of ADHD decrease as the immunotherapy duration increase and immunotherapy duration weakly correlated with risk of ADHD.

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Risk factors analysis of attention deficit/hyperactivity disorder and allergic rhinitis in children: a cross-sectional study

Cited by 16 publications

References 36 publications

Understanding the Link Between Allergy and Neurodevelopmental Disorders: A Current Review of Factors and Mechanisms

Understanding the Link Between Allergy and Neurodevelopmental Disorders: A Current Review of Factors and Mechanisms

Changes in Resting-State Spontaneous Brain Activity in Patients With Allergic Rhinitis: A Pilot Neuroimaging Study

Immunotherapy Duration and Risk of Psychosocial Emotion and Risk of Attention Deficit Hyperactivity Disorder Prevalence and Relation in Allergic Rhinitis Children

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