Risk factors and clinical correlates of neoplastic transformation in gastric hyperplastic polyps in Chinese patients

Abstract

remain unknown. This study aimed to analyze possible risk factors that are associated with the neoplastic transformation of gastric hyperplastic polyps. Results Demographics features. During January 2010 and June 2017, there were 6418 cases of gastric polyp diagnosed. 1115 of these (17.4%, 1115/6418) were histologically confirmed GHPs. 30 of these GHPs (2.69%, 30/1115) were diagnosed as containing dysplasia or adenocarcinoma. The mean age was 61.73 ± 9.024 years old (range 32-79). Absence of Helicobacter pylori was found in 63.6% (35/55). Within the 16 patients who showed evidence of neoplastic transformation there were 12 females and 4 males, the mean age was 63.44 ± 12.27 years (range 32-79). 9 (56.3%) of the patients who had GHPs with neoplastic transformation and 10 (25.6%) of the patients with pure GHPs had a history of anaemia. The patients who had a history of anaemia were more likely to have GHPs with evidence of neoplastic transformation (9/16 vs 10/39 in the GHP patients with or without neoplastic transformation, χ 2 = 4.701, P = 0.030) (Table 1). The initial indications for performing EGD were: 27 patients screening for early gastric cancer, 15 bloating, 4 abdominal pain, 7 heartburn or acid reflux and 2 anaemia. However, 20 patients (36.4%) actually had evidence of anaemia when tested. Only 3 patients took PPI, but all of them had normal fasting serum gastrin-17 concentrations.

The Relationship Between Hyperplastic Gastric Polyps And Helicobacter Pylori

“…In the recent studies, H. pylori's positivity rates in the HPs are similar with the present study. Yu et al and Hu et al found that H. pylori's positivity rates are 22.7% and 36.4%, respectively (17,18). Also, the study of Nam et al showed that H. pylori's eradication caused regression in HPs (19).…”

Gastric Hyperplastic Polyps after Argon Plasma Coagulation for Gastric Antral Vascular Ectasia in Patients with Liver Cirrhosis: A Case Suggesting the "Gastrin Link Theory"

“…In our case, H. pylori infection was negative, and no atrophy of the gastric mucosa evaluated by endoscopy was found. Moreover, previous studies of the pathogenesis of gastric hyperplastic polyps have shown that hypergastrinemia induced by severe atrophic gastritis of the corpus ( 25 - 29 ) or prolonged use of PPIs might induce the development of gastric hyperplastic polys ( 28 , 32 , 33 ). Gastrin has trophic effects on the gastrointestinal mucosa ( 34 ) and may repair gastric mucosal damage caused by APC.…”

“…However, rare cases of gastric polyps developing after APC therapy for GAVE have been reported ( 14 - 20 ) and termed “portal hypertension-associated polyps” or “portal hypertensive polyps” ( 21 - 24 ). The pathogenesis of gastric hyperplastic polyps is still unknown, but it is thought that the exaggerated repair of mucosal damage ( 25 , 26 ) or hypergastrinemia may play a role in the development of the polyps ( 27 - 29 ).…”

Gastritis, Gastric Polyps and Gastric Cancer

“…Interestingly, fundic argyrophil hyperplasia which reflects hyperplasia of ECL cells and thus hypergastrinemia, was already in 1984 described to be associated to HPs [ 92 ]. A trend towards hypergastrinemia as risk factor for malignant progression of hyperplastic polyps has also been reported [ 93 ]. The prevalence of dysplasia in sporadic hyperplastic polyps has been reported to be in the range 1.9–19% [ 94 ], with a marked association with size [ 95 ].…”