2015
DOI: 10.1186/s12885-015-1376-9
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Risk factors and clinical outcomes of acute myeloid leukaemia with central nervous system involvement in adults

Abstract: BackgroundAcute myeloid leukaemia (AML) with central nervous system (CNS) involvement in adults is uncommon, and studies of this subject are scant.MethodsWe conducted a retrospective study to investigate the clinical aspects, cytogenetic abnormalities, molecular gene mutations and outcomes of adult AML patients with CNS involvement. Three hundred and ninety-five patients with newly diagnosed AML were reviewed.ResultsTwenty (5.1%) patients had CNS involvement, including 7 (1.8%) with initial CNS disease and 4 (… Show more

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Cited by 53 publications
(78 citation statements)
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“…In adult AML protocols, a diagnostic LP is not performed in order to prevent contamination of the CSF with blasts unless there are signs of CNS disease present. [2][3][4] Our data suggest that traumatic taps in patients who are treated similar to our protocols do not confer a higher risk of treatment failure.…”
Section: Patient Outcomesmentioning
confidence: 61%
“…In adult AML protocols, a diagnostic LP is not performed in order to prevent contamination of the CSF with blasts unless there are signs of CNS disease present. [2][3][4] Our data suggest that traumatic taps in patients who are treated similar to our protocols do not confer a higher risk of treatment failure.…”
Section: Patient Outcomesmentioning
confidence: 61%
“…101,102 In older patients, in whom the risk of rebleeding is significantly high and allogeneic transplantation is not a practical option, we consider less myeloablative therapy, such as hydroxyurea, low-dose cytarabine, or hypomethylating agents. 100,103 This patient has a high risk for CNS involvement based on the myelomonocytic lineage morphology and leukocytosis [104][105][106] but there is no firm evidence to suggest a connection between ICH and CNS involvement of leukemia. 107 Although ICH preceded the diagnosis of leukemia by 6 weeks and the patient has poorly controlled hypertension For personal use only.…”
Section: Questionsmentioning
confidence: 96%
“…AML rarely invades areas other than the bone marrow, but in such instances, the most commonly afflicted organs are soft tissues, lymphatic tissues, and skin [6][7][8][9]. Central Nervous System involvement (CNSi) is rare [10][11][12][13].…”
Section: Introductionmentioning
confidence: 99%