Risk factors and clinical prediction models for osteoporosis in pre-dialysis chronic kidney disease patients

Kuang, Chaoying; Shang, Jingjie; Ma, Mingming; Huang, Shengling; Yan, Bing; Zhong, Yuzhen; Guan, Baozhang; Gong, Jian; Liu, Fanna; Chen, Liangmei

doi:10.1080/0886022x.2024.2361802

Renal Failure

2024

DOI: 10.1080/0886022x.2024.2361802

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Risk factors and clinical prediction models for osteoporosis in pre-dialysis chronic kidney disease patients

Chaoying Kuang,

Jingjie Shang,

Mingming Ma

et al.

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2024

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The Management of Osteoporosis in Chronic Kidney Disease: A Review of Diagnostic and Therapeutic Approaches

Tariq,

Ahmad,

Subhan

et al. 2024

Cureus

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Chronic kidney disease (CKD) has shown a growing association with osteoporosis, comprising part of the broader CKD-mineral and bone disorder (CKD-MBD). CKD-MBD is marked by alterations in calcium, phosphorus, parathyroid hormone (PTH), and vitamin D metabolism, significantly elevating fracture risk. While traditional osteoporosis treatments such as bisphosphonates, denosumab, and teriparatide have been adapted for CKD patients, recent innovations have introduced agents aimed at enhancing bone mass and reducing fracture incidence. This study aims to evaluate the pathophysiology, diagnostic methods, and tailored management strategies for osteoporosis in CKD patients. A detailed review of the literature was conducted, involving an in-depth search of PubMed, Medical Literature Analysis and Retrieval System Online (MEDLINE), and the Cochrane Library databases for studies published between 2017 and 2024. Studies were selected based on inclusion criteria focusing on CKD-related osteoporosis, diagnostic criteria, and treatment outcomes. Data extraction and quality assessment were independently performed by multiple reviewers to ensure thoroughness and reduce bias. Findings highlight that conventional treatments, such as bisphosphonates, denosumab, and teriparatide, when tailored to CKD stages, demonstrate variable effectiveness in lowering fracture risk.Additionally, emerging pharmacologic agents hold promise in improving bone density, though evidence on these newer therapies remains limited. Osteoporosis management in CKD patients necessitates a personalized approach guided by the disease's stage and individual profile. This review underscores the potential of emerging therapies and emphasizes the need for further research to refine treatment protocols, aiming to enhance patient outcomes in this complex population.

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The Management of Osteoporosis in Chronic Kidney Disease: A Review of Diagnostic and Therapeutic Approaches

Tariq,

Ahmad,

Subhan

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

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Risk factors and clinical prediction models for osteoporosis in pre-dialysis chronic kidney disease patients

Cited by 1 publication

References 57 publications

The Management of Osteoporosis in Chronic Kidney Disease: A Review of Diagnostic and Therapeutic Approaches

The Management of Osteoporosis in Chronic Kidney Disease: A Review of Diagnostic and Therapeutic Approaches

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