Risk factors and future directions for preventing and diagnosing exertional rhabdomyolysis

Carneiro, A S; Gomes, Diego Viana; Macedo-da-Silva, Janaína; Lima, Giscard; Mitri, Simone; Alves, Sérgio Rabello; Kolliari-Turner, Alexander; Zanoteli, Edmar; Neto, Francisco Radler de Aquino; Palmisano, Giuseppe; Pesquero, João Bosco; Moreira, Josino Costa; Pereira, Marcos D.

doi:10.1016/j.nmd.2021.04.007

Cited by 15 publications

(17 citation statements)

References 102 publications

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“…The extravasated Fe 2+ participates in the fenton reaction, forming ROS. Several proteins related to the inflammatory process and oxidative stress are overexpressed after strenuous physical exercise, possibly to detoxify this insult (Carneiro et al, 2021;Van Avondt et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Data from 2019 revealed that amongst US armed service members the occurrence of ERM is 38.9 per 100,000 people/year. In addition, the rate in the Marine Corps subgroup is 91.9 per 100,000 people/year, with the youngest and the least time on duty, those of African descent, and those with less education being most affected (Carneiro et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Urine proteomics as a non-invasive approach to monitor exertional rhabdomyolysis during military training

Carneiro

Macedo-da-Silva

Santiago

et al. 2022

Journal of Proteomics

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Urine proteomics as a non-invasive approach to monitor exertional rhabdomyolysis during military training

Carneiro

Macedo-da-Silva

Santiago

et al. 2022

Journal of Proteomics

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Section: Discussionmentioning

confidence: 99%

Urine proteomics as a non-invasive approach to monitor exertional rhabdomyolysis during military training

Carneiro

Macedo-da-Silva

Santiago

et al. 2021

Preprint

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Exertional rhabdomyolysis (ERM), a condition often associated with strenuous exercise, a common practice in the military activities, can be defined as the process of injury and rupture of muscle cell membranes, with leakage of its components into the blood stream. Creatine kinase (CK) has been extensively used for ERM diagnosis, albeit several studies reported the discrepancy between CK levels and clinical signs or symptoms. In this study, we analyzed the biochemical profile of the blood, and the urinary proteome of ten marine soldiers in a special training course. The samples were collected in two periods, M1 and M2, which correspond to the lowest and highest CK levels during training, respectively. Quantitative urinary proteome profile of M1 and M2 was determined showing changes with highest significance in immune system and cell adhesion-related pathways after strenuous physical exercise. Changes in the abundance of several proteins was observed in individuals carrying genetic polymorphisms related to greater risk for muscle damage. Remarkably, we identified a panel of proteins (CTSH, PIK3IP1, DEFB1, ITGB1, BCAN, and TNFRSF10C) that present high correlation with three classical blood biochemical markers of ERM and AGT MET235Thr and ACE I/D polymorphisms. These proteins represent potential urine markers of muscle damage due to intense physical conditions such as military training activities.

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“…Viral infection, drug and alcohol addiction, exercise in extremely hot and humid situations, genetic polymorphisms such as sickle cell trait and McArdle disease, and epigenetic alterations have all been documented to increase the chance of the condition in athletes. 15 Functionally, loss of strength results from disturbed calcium homeostasis, disruption of excitationcontraction coupling, disruption of force transmission, and metabolic alterations. It's significant to note that the trauma also triggers an inflammatory response, which manifests clinically as edema, restricted range of motion, elevated passive tension, discomfort, and a momentary decline in insulin sensitivity.…”

Section: Complicationsmentioning

confidence: 99%

Etiology, risk factors and complications of exercise induced muscle injury

Sunbol¹,

Althiyabi²,

Alshuria³

et al. 2022

Int J Community Med Public Health

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Healthy lifestyle includes physical activity as the basic component however, exercises with eccentricity have been associated to a higher risk of muscle injury and slower recovery. The development of exercise-induced muscle injury is a phenomenon that results from atypical or unaccustomed activity; the intensity of the pain and the extent of the damage steadily deteriorate over time, and when the exercise session contains an eccentric component, they may last for several days. Increasing levels of muscle-specific circulating protein are present, along with increased levels of muscular pain and decreased muscle strength. The extent of severity of the symptoms following eccentric exercise varies greatly. Exercise-induced muscle injury is influenced by a number of factors including intensity, duration, mode, muscle group, age, gender, genetics, and dietary state. Numerous scientific studies illustrate the circumstances under which exercise causes muscle injury. It is widely acknowledged that exercise that is unfamiliar, particularly exercise that involves eccentric contractions, causes damage. exercise-induced muscle injury is accompanied by an inflammatory response involving numerous mediators, including the production of muscle-specific creatine kinase and interleukins and interleukins receptor antagonist and acute phase proteins. Complications of exercise-induced muscle injury include temporary muscle inflammation, loss of strength, muscle discomfort, restricted range of motion, elevated passive tension, discomfort, and a momentary decline in insulin sensitivity and can also lead to rhabdomyolysis. The purpose of this research is to review the available information about an etiology, risk factors and complications of exercise-induced muscle injury.

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Risk factors and future directions for preventing and diagnosing exertional rhabdomyolysis

Cited by 15 publications

References 102 publications

Urine proteomics as a non-invasive approach to monitor exertional rhabdomyolysis during military training

Urine proteomics as a non-invasive approach to monitor exertional rhabdomyolysis during military training

Urine proteomics as a non-invasive approach to monitor exertional rhabdomyolysis during military training

Etiology, risk factors and complications of exercise induced muscle injury

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