Risk factors and long‐term outcomes of parvovirus B19 infection in kidney transplant patients

Baek, Chung Hee; Kim, Hyosang; Yang, Won Seok; Han, Duck Jong; Park, Su-Kil

doi:10.1111/tid.12754

Cited by 21 publications

(15 citation statements)

References 25 publications

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“…Few studies have been carried out worldwide on the detection of B19V DNA in patients under dialysis; most surveys have been focused on the prevalence of B19V in kidney transplant recipients (Rosado-Canto et al, 2019;Hai An et al, 2019;Baek et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

High prevalence of parvovirus B19 infection in patients with chronic kidney disease under hemodialysis: A multicenter study

Alves

Langella

Barbosa

et al. 2020

International Journal of Infectious Diseases

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Objectives: Parvovirus B19 (B19V) infection is commonly acute and self-limited, but in chronic kidney disease (CKD) patients under dialysis treatment, this infection could increase susceptibility to acute and chronic anemia. The aim of this study was to evaluate the frequency and risk of B19V infection among Brazilian CKD patients under dialysis. Methods: A study was conducted among 221 CKD patients and a control group of 142 blood donors. B19V infection was evaluated in serum samples by real-time PCR, and ELISA (anti-B19V IgM and IgG). Results: B19V DNA was detected in 65% (145/221) of CKD patients, which was significantly higher (p < 0.001) than in the blood donors (6.3%). Simultaneous detection of B19V IgG and viremia was shown in 40.3% of CKD patients, which was indicative of persistent B19V infection. CKD patients showed an increased risk of developing B19V infection (OR = 28.1, CI = 13.5-58.5, p = 0.001). Conclusions: Despite an absence of clinical signs of B19V infection, these data highlight the importance of B19V infection in this high-risk population, since a persistent B19V infection could become clinically significant after renal transplant. Moreover, the persistent viremia should be considered as a potential risk, mainly because of the contamination of dialysis equipment.

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Section: Discussionmentioning

confidence: 99%

High prevalence of parvovirus B19 infection in patients with chronic kidney disease under hemodialysis: A multicenter study

Alves

Langella

Barbosa

et al. 2020

International Journal of Infectious Diseases

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“…[ 2 ] The epidemiology of parvovirus B19 and parvovirus B19-related anemia after KTx remains unclear. [ 5 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 ]…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of parvovirus B19 and anemia among kidney transplant recipients: A meta-analysis

et al. 2020

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Background: Persistent anemia has been described in kidney transplant (KTx) recipients with parvovirus B19 virus infection. However, the epidemiology of parvovirus B19 and parvovirus B19-related anemia after KTx remains unclear. We conducted this systematic review (1) to investigate the incidence of parvovirus B19 infection after KTx and (2) to assess the incidence of parvovirus B19 among KTx patients with anemia. Materials and Methods: A systematic review was conducted in EMBASE, MEDLINE, and Cochrane databases from inception to March 2019 to identify studies that reported the incidence rate of parvovirus B19 infection and/or seroprevalence of parvovirus B19 in KTx recipients. Effect estimates from the individual studies were extracted and combined using random-effects, generic inverse variance method of DerSimonian and Laird. The protocol for this systematic review is registered with PROSPERO (no. CRD42019125716). Results: Nineteen observational studies with a total of 2108 KTx patients were enrolled. Overall, the pooled estimated seroprevalence of parvovirus B19 immunoglobulin G was 62.2% (95% confidence interval [CI]: 45.8%–76.1%). The pooled estimated incidence rate of positive parvovirus B19 DNA in the 1 st year after KTx was 10.3% (95% CI: 5.5%–18.4%). After sensitivity analysis excluded a study that solely included KTx patients with anemia, the pooled estimated incidence rate of positive parvovirus B19 DNA after KTx was 7.6% (95% CI: 3.7%–15.0%). Among KTx with anemia, the pooled estimated incidence rate of positive parvovirus B19 DNA was 27.4% (95% CI: 16.6%–41.7%). Meta-regression analysis demonstrated no significant correlations between the year of study and the incidence rate of positive parvovirus B19 DNA ( P = 0.33). Egger's regression asymmetry test was performed and demonstrated no publication bias in all analyses. Conclusion: The overall estimated incidence of positive parvovirus B19 DNA after KTX is 10.3%. Among KTx with anemia, the incidence rate of positive parvovirus B19 DNA is 27.4%. The incidence of positive parvovirus B19 DNA does not seem to decrease overtime.

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“…Baek et al [13] showed that nearly 90% of positive cases were reported within the first year after kidney transplantation. The major risk factor for parvovirus B19 infection is immunosuppression, which is shown due to resolution of anemia when immunosuppression is lowered [14].…”

Section: Discussionmentioning

confidence: 99%

Parvovirus Infection-Related Anemia after Kidney Transplantation

Sharma

Bajwa

2020

Case Reports in Transplantation

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Anemia postkidney transplantation is an important issue which has been correlated with increased hospitalizations and higher mortality. Infections, including those due to parvovirus B19, CMV, and BK virus (polyomavirus), have also been associated with an increased risk of anemia. Here, we present a case of new-onset anemia in a kidney transplant recipient within 3 months of transplant. The patient was found to have multiple viral infections from parvo B19, BK virus, and rhinovirus. The anemia resolved completely after successful reduction in the parvo B19 and BK viral load. Workup for viral infections must be considered in the differential diagnosis of postkidney transplant anemia.

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Risk factors and long‐term outcomes of parvovirus B19 infection in kidney transplant patients

Abstract: The identification of factors related to positive parvovirus B19 PCR results may promote the early detection of parvovirus B19 infection. Further studies are needed to elucidate the characteristics of parvovirus B19 infection in kidney transplantation.

Cited by 21 publications

References 25 publications

High prevalence of parvovirus B19 infection in patients with chronic kidney disease under hemodialysis: A multicenter study

High prevalence of parvovirus B19 infection in patients with chronic kidney disease under hemodialysis: A multicenter study

Epidemiology of parvovirus B19 and anemia among kidney transplant recipients: A meta-analysis

Parvovirus Infection-Related Anemia after Kidney Transplantation

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