Risk factors and morbidity of infantile haemangioma: preterm birth promotes ulceration

Castrén, Eeva; Salminen, Päivi; Gissler, Mika; Stefanović, Vedran; Pitkäranta, Anne; Klockars, Tuomas

doi:10.1111/apa.13460

Cited by 20 publications

(31 citation statements)

References 29 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among the complications of infantile hemangiomas, ulceration is the most common; it occurs in approximately 15% to 25% of cases and can produce bleeding in 40% with a subsequent scar . Preterm neonates have been reported to have a higher risk of ulceration in hemangiomas . On sonography, there is an abrupt loss of the hyperechoic line of the epidermis and poorly defined decreased echogenicity of the dermis, increased echogenicity of the hypodermis, or both.…”

Section: Dermatologic Emergencies On Sonographymentioning

confidence: 99%

Sonography of Dermatologic Emergencies

Wortsman

2017

J of Ultrasound Medicine

View full text Add to dashboard Cite

Dermatologic conditions may be the subjects of potential emergency consultations, and the knowledge of their sonographic appearance can facilitate an early diagnosis and management. In this pictorial essay, the sonographic dermatologic anatomy, technique, and conditions that can be supported by a prompt sonographic diagnosis are reviewed. The sonographic signs that may help diagnose these entities are discussed with a practical approach.

show abstract

Section: Dermatologic Emergencies On Sonographymentioning

confidence: 99%

Sonography of Dermatologic Emergencies

Wortsman

2017

J of Ultrasound Medicine

View full text Add to dashboard Cite

show abstract

“…Although it is known that efficacy increases with gestation period, there have been few reports of therapeutic effects in premature infantile hemangioma patients, so there is not yet consensus on this issue. The number of infantile hemangioma lesions in premature infants is high, and infantile hemangioma is reportedly more severe in such patients . In addition, infantile hemangioma exhibits a characteristic sequence of growth and spontaneous involution .…”

Section: Discussionmentioning

confidence: 99%

“…The number of infantile hemangioma lesions in premature infants is high, and infantile hemangioma is reportedly more severe in such patients. [27][28][29] In addition, infantile hemangioma exhibits a characteristic sequence of growth and spontaneous involution. 2 Thus, including effects of treatment duration and gestational age on the baseline was justifiable because pathology and disease progression of infantile hemangioma may influence placebo effects.…”

Section: Discussionmentioning

confidence: 99%

Population Pharmacokinetics and Pharmacodynamics of Oral Propranolol in Pediatric Patients With Infantile Hemangioma

Takechi

Kumokawa

Kato

et al. 2018

The Journal of Clinical Pharma

View full text Add to dashboard Cite

This study aimed to characterize the population pharmacokinetics and exposure‐response relationship of propranolol (Hemangiol® Syrup for Pediatric) in infants with infantile hemangioma. Using nonlinear mixed‐effects modeling with 63 pooled sets of plasma concentration‐time data from 32 Japanese patients aged 35‐150 days, we described the disposition of propranolol adequately by a 1‐compartment model with first‐order absorption. The estimated population mean apparent clearance and apparent central volume of distribution were 9.34 L/h and 146 L, respectively. Body weight and postnatal age influenced the population pharmacokinetic model. The clinical end points—success (complete or nearly complete resolution of the target hemangioma) and failure—at weeks 12 and 24 were characterized by logistic regression using the area under the concentration‐time curve (AUC), estimated from the final population pharmacokinetic model, as an exposure predictor. The logistic regression showed that a higher AUC was associated with a higher probability of successful treatment. At each exposure level, probability of successful treatment was correlated with gestational age and treatment duration. Model‐predicted probabilities of successful treatment were consistent with actual results in the clinical trial. Simulations using several dosing regimens indicated that oral propranolol at 3 mg/kg per day was effective and would be appropriate for treating Japanese infants. These simulation results can support optimization of dosing regimens, such as selecting amounts, treatment durations, and dosing intervals, for clinical use.

show abstract

“…Long-term morbidity and discomfort resulting from IHs have previously been linked to head and neck, segmental, and complicated IHs. 23,24 In the present study, we evaluated any kind of discomfort due to a residual IH reported by the patients. Surprisingly, the long-term discomfort rate was higher in those IH children with affected first-degree relatives than in the sporadic IH patients.…”

Section: Discussionmentioning

confidence: 99%

“…The IH characteristics and risk factors of these 185 children have been studied and published in detail elsewhere. 23 We sent a questionnaire (see Supplemental Figure 4 A and B) to these 185 children with IH concerning perinatal data, current diseases, family history of IH, and current IH-related discomfort (on the basis of a visual analog scale from 1 [no discomfort] to 10 [very significant discomfort]). All families who responded to the questionnaire signed an informed consent form.…”

Section: Patientsmentioning

confidence: 99%