Risk factors and outcomes associated with the carriage of tigecycline- and vancomycin-resistant

Kessel, Johanna; Bender, Jennifer K.; Werner, Guido; Griskaitis, Matas; Herrmann, Eva; Lehn, Annette; Zacharowski, Kai; Zeuzem, Stefan; Vehreschild, Maria J.G.T.; Wichelhaus, Thomas A.; Kempf, Volkhard A. J.; Hogardt, Michael

doi:10.1016/j.jinf.2020.12.003

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…The risk of tracheotomy ranks first, followed by shock, gastrointestinal bleeding and tigecycline in patients, which implies that early use of tracheostomy in the treatment of patients significantly increases the risk of bloodstream infection. Recent studies have also focused on the use of tigecycline 13 , and some studies have also found a significant correlation between tigecycline use and higher mortality rates in critically ill patients with BSI 13 , 14 . Therefore, careful attention should be paid to the use of tigecycline in ICU patients.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for bloodstream infection among patients admitted to an intensive care unit of a tertiary hospital of Shanghai, China

Cui,

Yi,

Zhang

et al. 2024

Sci Rep

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Blood flow infections (BSIs) is common occurrences in intensive care units (ICUs) and are associated with poor prognosis. The study aims to identify risk factors and assess mortality among BSI patients admitted to the ICU at Shanghai Ruijin hospital north from January 2022 to June 2023. Additionally, it seeks to present the latest microbiological isolates and their antimicrobial susceptibility. Independent risk factors for BSI and mortality were determined using the multivariable logistic regression model. The study found that the latest incidence rate of BSI was 10.11%, the mortality rate was 35.21% and the mean age of patients with BSI was 74 years old. Klebsiella pneumoniae was the predominant bacterial isolate. Logistic multiple regression revealed that tracheotomy, tigecycline, gastrointestinal bleeding, shock, length of hospital stay, age and laboratory indicators (such as procalcitonine and hemoglobin) were independent risk factors for BSI. Given the elevated risk associated with use of tracheotomy and tigecycline, it underscores the importance of the importance of cautious application of tracheostomy and empirical antibiotic management strategies. Meanwhile, the independent risk factors of mortality included cardiovascular disease, length of hospital stay, mean platelet volume (MPV), uric acid levels and ventilator. BSI patients exhibited a significant decrease in platelet count, and MPV emerged as an independent factor of mortality among them. Therefore, continuous monitoring of platelet-related parameters may aid in promptly identifying high-risk patients and assessing prognosis. Moreover, monitoring changes in uric acid levels may serve as an additional tool for prognostic evaluation in BSI patients.

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Section: Discussionmentioning

confidence: 99%

Risk factors for bloodstream infection among patients admitted to an intensive care unit of a tertiary hospital of Shanghai, China

Cui,

Yi,

Zhang

et al. 2024

Sci Rep

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“…It can not only cause urinary tract infections, skin infections, and soft tissue infections but also cause life-threatening abdominal infection, sepsis, pericarditis, and meningitis. Enterococcus can produce many factors related to pathological changes in the host [ 36 ]. Polymorphonuclear leukocyte chemokines produced by Enterococcus faecalis can mediate, or at least partially mediate, the inflammatory response usually associated with enterococcal infection.…”

Section: Discussionmentioning

confidence: 99%

Explore and Analyze the Composition and Characteristics of Intestinal Microbiota between Gastric Cancer Patients and Healthy People

Wang

Yang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Gastric cancer is one of the most common malignant tumors in the world. As the intestine is downstream of the digestive tract, the occurrence of gastric cancer may have a certain significant impact on it. Therefore, it is particularly important to find out the intestinal bacteria closely related to gastric cancer, to identify the specific flora related to gastric cancer, and to maintain the stability of the core structure of intestinal microecology in patients with gastric cancer. Based on this, the fecal samples of gastric cancer patients and healthy people were collected, and the diversity and composition of intestinal flora in patients with gastric cancer were analyzed by 16S rRNA sequencing technology. We found that there was no significant difference in the diversity and abundance of intestinal flora between gastric cancer patients and healthy people. The relative abundance of Faecalibacterium, Bifidobacterium, and Subdoligranulum in the intestinal tract of patients with gastric cancer was significantly lower than that in healthy people, while the relative abundance of Enterococcus, Streptococcus, and Bacteroides was increased. This study found that there were six kinds of intestinal microflora closely related to the occurrence of gastric cancer, which provided a theoretical basis for further exploring the pathogenesis of gastric cancer.

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“…Currently, they have become major opportunistic pathogens due to considerably higher resistant to antimicrobials, becoming a leading major cause of multidrug-resistant bacterial infections, especially in critically ill and immunocompromised patients with prolonged-course antimicrobial treatments and/or prolonged hospital stays (Ruhal and Kataria, 2021). Moreover, some stains of Enterococcus faecium have developed strong levels of resistance to ampicillin, vancomycin and aminoglycosides, which are three of the traditionally most useful anti-enterococcal antibiotics, being a significant danger and pose a risk to public health (Kessel et al, 2021). While studies have revealed that there are newer antibiotics such as linezolid, daptomycin and tigecycline with superior in vitro activity against enteric isolation, the success rate of clinical use has also been reduced by the emergence of resistance (Tran et al, 2015;Smith et al, 2018;Yi et al, 2022).…”

Section: Introduction 1backgroundmentioning

confidence: 99%

A natural product noraucupatin against multidrug-resistant Enterococcus faecium: an inhibition mechanism study

et al. 2023

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Background: This work elucidates the antimicrobial activity and mechanism of action of the natural product noraucupatin against MDR Enterococcus faecium. E. faecium has become a major opportunistic pathogen with the worldwide spread of multidrug-resistant (MDR) isolates, especially vancomycin-resistant enterococci (VRE), belongs to “ESKAPE” organisms causing significant problems widely. Hence, there is a pressing need to discover new promising drugs or alternative therapies. Fortunately, we found a natural product noraucupatin (C13H12O3, a biphenyl compound) with “extremely encouraging” anti-clinical drug-resistant bacterial activity isolated from yeast-induced Rowan suspension cells. A comprehensive and in-depth exploration of antimicrobial mechanisms will bring fresh insights for researchers to develop novel antimicrobial strategies against MDR bacteria.Methods: The antibacterial effect of noraucupatin against MDR E. faecium is investigated from a microbial metabolism perspective using microcalorimetry. The antibacterial effect is determined based on the thermodynamic parameters. Based on spectroscopic techniques, microscopy techniques and confocal scanning laser microscopy with membrane probes, the antibacterial mechanism is elucidated definitely.Results: Comparing with the IC50 of noraucupatin against MDR Enterococcus faecalis, MRSA, CRPA, the IC50 of noraucupatin against MDR E. faecium was just 67.54 μM. The growth rate of MDR E. faecium decreases with the increase of concentration of noraucupatin. The bacterial intracellular structure entirely collapses and the slurries flow out under the influence of high levels of noraucupatin by TEM. The changes of membrane potential, permeability and evidences of nucleic acid leakage was obtained by CSLM and UV, the mechanism of noraucupatin against MDR E. faecium we explored.Conclusion: The present study highlights the excellent antibacterial activity of noraucupatin against MDR E. faecium by altering the permeability of the membrane and disrupting the membrane potential leading to electrolyte permeation. In addition, noraucupatin has excellent biocompatibility through its haemolytic activity in rabbit erythrocyte. These findings suggest that noraucupatin could be used in infectious diseases caused by MDR E. faecium.

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Risk factors and outcomes associated with the carriage of tigecycline- and vancomycin-resistant

Cited by 7 publications

References 26 publications

Risk factors for bloodstream infection among patients admitted to an intensive care unit of a tertiary hospital of Shanghai, China

Risk factors for bloodstream infection among patients admitted to an intensive care unit of a tertiary hospital of Shanghai, China

Explore and Analyze the Composition and Characteristics of Intestinal Microbiota between Gastric Cancer Patients and Healthy People

A natural product noraucupatin against multidrug-resistant Enterococcus faecium: an inhibition mechanism study

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