Risk Factors and Outcomes of Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplantation

Kukreja, Jasleen; Tsou, Sarah; Chen, Joy; Trinh, B.; Feng, Chun-Miao; Golden, Jeffrey A.; Hays, Steven R.; Deuse, T.; Singer, Jonathan P.; Brzeziński, Marek

doi:10.1053/j.semtcvs.2020.05.008

Cited by 28 publications

(16 citation statements)

References 22 publications

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“… Hoetzenecker et al (2018) [ 8 ••] Additional organ system dysfunction Patients with other organ dysfunction, such as liver or kidney dysfunction, carry an increased risk of morbidity and mortality. Certainly, irreversible organ dysfunction should be strongly considered as a contra-indication to BTT Tipograf et al (2019) [ 9 ••] Kukreja et al (2020) [ 19 ] Deconditioning Quantifying the level of deconditioning is difficult. However, the higher the potential for deconditioning during the bridging period, the higher is the incidence of CIM postoperatively.…”

Section: Extracorporeal Life Support As a Bridge To Transplantmentioning

confidence: 99%

“…(2016) [ 11 ] Minor risk factors Type of ECMO-BTT Venovenous ECMO is associated with improved survival compared with more advanced support. VA-ECMO denotes a more critically-ill patient, and naturally, suggests less success Kukreja et al (2020) [ 19 ] Center volume/experience Centers with more experience with lung transplants and ECMO are likely to have greater success using ECMO as BTT. This is true with more complex patients that require more advanced ECLS.…”

Section: Extracorporeal Life Support As a Bridge To Transplantmentioning

confidence: 99%

“…The study by Kukreja et al demonstrates that right heart dysfunction may be bridged successfully. However, it is associated with worse outcomes [ 19 ]. In addition to cardiac dysfunction, the presence of other organ dysfunction, such as renal failure, is a predictor for mortality [ 9 ••].…”

Section: Extracorporeal Life Support As a Bridge To Transplantmentioning

confidence: 99%

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Lung Transplant from ECMO: Current Results and Predictors of Post-transplant Mortality

2021

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Purpose of Review We examined data from the last 5 years describing extracorporeal life support (ECLS) as a bridge to lung transplantation. We assessed predictors of survival to transplantation and post-transplant mortality. Recent Findings The number of lung transplants performed worldwide is increasing. This is accompanied by an increase in the type of patients being transplanted, including sicker patients with more advanced disease. Consequently, there is an increase in the need for bridging strategies, with varying success. Several predictors of failure have been identified. Major risk factors include retransplantation, other organ dysfunction, and deconditioning. Summary ECLS is a risky strategy but necessary for patients who would otherwise die if not bridged to transplantation. The presence of predictors for failure is not a contraindication for bridging. However, major risk factors should be approached cautiously. Other, more minor risk factors may be considered acceptable. More importantly, the strategy should be individualized for each patient to achieve the best possible outcomes.

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Section: Extracorporeal Life Support As a Bridge To Transplantmentioning

confidence: 99%

Section: Extracorporeal Life Support As a Bridge To Transplantmentioning

confidence: 99%

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Lung Transplant from ECMO: Current Results and Predictors of Post-transplant Mortality

2021

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“…ECMO is an extracorporeal system containing a pump and an oxygenator that allows the lungs and/or heart to be replaced for some time by extracorporeal oxygenation of the blood and elimination of carbon dioxide. Such actions increase the chance that the organ will be suitable for transplantation and that it will function properly [24,25].…”

Section: Determining Irreversible Cardiac Arrest In Practicementioning

confidence: 99%

Legal and organizational aspects of organ donation after irreversible cardiac arrest

Szarpak¹,

Bielski²,

Smereka

et al. 2020

Disaster Emerg Med J

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Sudden cardiac arrest is a challenge for medical personnel. Donation after circulatory death (DCD) has opened new perspectives and could be a valuable option to expand the brain-dead donors. The purpose of this review is to provide an overview of current legal and organizational aspects of organ donation after irreversible cardiac arrest. The article presents basic issues related to the epidemiology of sudden cardiac arrest, criteria for the diagnosis of irreversible cardiac arrest. It also discusses special situations related to cardiac arrest and determining irreversible cardiac arrest in practice. Much attention has been paid to donor organ transplantation after irreversible cardiac arrest in the context of scientific research. This article aimed to present the Polish statutory and administrative regulations concerning donation after circulatory death. Following the 2010 Minister of Health's Notice on Criteria and Methods of Determining Irreversible Cardiac arrest, it should be stated that it legally allows for all types of donation included in the Mastricht classification.

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“…In this edition, Kukreja et al proffer a retrospective review from a single center in which they analyze data pertaining to patients who required extracorporeal support as a bridge to lung transplantation between 2010 and 2018. 1 The analysis elucidates differences in outcomes between those successfully bridged versus those who failed. Additionally, the authors report discrepancies in results in recipients who were listed electively versus those listed emergently.…”

mentioning

confidence: 99%

Commentary: Burning Your Bridges

Hayanga

Dhamija

Hayanga

et al. 2020

Seminars in Thoracic and Cardiovascular Surgery

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Risk Factors and Outcomes of Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplantation

Cited by 28 publications

References 22 publications

Lung Transplant from ECMO: Current Results and Predictors of Post-transplant Mortality

Lung Transplant from ECMO: Current Results and Predictors of Post-transplant Mortality

Legal and organizational aspects of organ donation after irreversible cardiac arrest

Commentary: Burning Your Bridges

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