Risk Factors and Outcomes of Very Young Adults Who Experience Myocardial Infarction: The Partners YOUNG-MI Registry

Yang, Junjie; Biery, David; Singh, Avinainder; Divakaran, Sanjay; DeFilippis, Ersilia M.; Wu, Winona; Klein, Josh; Hainer, Jon; Ramsis, Mattheus; Natarajan, Pradeep; Januzzi, James L.; Nasir, Khurram; Bhatt, Deepak L.; Carli, Marcelo F. Di; Blankstein, Ron

doi:10.1016/j.amjmed.2019.10.020

Cited by 101 publications

(108 citation statements)

References 31 publications

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“…Moreover, multivariate analysis selects bacteria as an independent predictor. The great interest of AMI in young patients tries to explain mechanisms of infarction and to discover nontraditional risk factors [30,31]. Spontaneous coronary artery dissection, plaque erosion, coronary microvascular dysfunction, myocarditis, coronary embolism, hypercoagulability, and coronary spasm are proved to cause myocardial infarction in this group of patients.…”

Section: Discussionmentioning

confidence: 99%

Association between age and infection in patients with acute ST-elevation myocardial infarction

Algowhary

2021

Egypt Heart J

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Background ST-elevation myocardial infarction (STEMI) in young patients has a unique risk profile. We aimed to detect bacteria in aspirate of infarct artery in young versus old patients. Results Aspirates of consecutive 140 patients who underwent a primary coronary intervention were taken for bacteriological, microscopical, and immunohistochemical (for bacterial pneumolysin) examinations. Their results were calculated in young (≤ 50 years) versus old (> 50 years) patients. Median age (interquartile range) was 45 (38–48) years in young (60 patients) and 59 (55–65) years in old (80 patients) patients, p < 0.0001. Both groups had similar baseline data except age, males, diabetes, hyperlipidemia, family history, lesion length, and ectatic vessel. Different bacteria were cultured in 11.3% of all patients involving 22.6% of young and 2.8% of old patients [hazard ratio 8.03 (95% CI 1.83–51.49), p = 0.002]. By multivariate analyses, age groups and leukocytic count were independent predictors of infection (bacteria and pneumolysin), p = 0.027 and p < 0.0001, respectively. Optimal cutoff value of leukocytic count was 12,250 cells/μl [ROC curve sensitivity 85.7%, specificity 86.4%, and AUC 0.97 (95% CI 0.95–1.0), p < 0.001]. Infection was an independent predictor of STEMI in young versus old patients, p < 0.001. Nevertheless, in-hospital events occurred insignificantly different and neither age groups nor infection was predictor of in-hospital events. Conclusions Young patients had significantly higher percentage of bacteria in their infarcted artery than old patients. High leukocytic count in patients below 50 predicts infection that causes acute myocardial infarction. Antibacterial trials directed toward this group are required for secondary prevention.

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Section: Discussionmentioning

confidence: 99%

Association between age and infection in patients with acute ST-elevation myocardial infarction

Algowhary

2021

Egypt Heart J

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“…Detailed definitions of all risk factors, including how the CCI was calculated, 36 as well as how the extent and severity of disease were quantified, are provided in eAppendix 1 in the Supplement and have been previously published. 32 , 37 …”

Section: Methodsmentioning

confidence: 99%

Association of Smoking Cessation and Survival Among Young Adults With Myocardial Infarction in the Partners YOUNG-MI Registry

et al. 2020

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“… 5 , 6 , 7 , 8 , 9 , 10 Furthermore, patients with premature ASCVD experience similar rates of all-cause and cardiovascular mortality compared with older adults. 11 , 12 , 13 , 14 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of Aspirin and Statin Therapy Use and Adherence in Patients With Premature Atherosclerotic Cardiovascular Disease

et al. 2020

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Risk Factors and Outcomes of Very Young Adults Who Experience Myocardial Infarction: The Partners YOUNG-MI Registry

Cited by 101 publications

References 31 publications

Association between age and infection in patients with acute ST-elevation myocardial infarction

Association between age and infection in patients with acute ST-elevation myocardial infarction

Association of Smoking Cessation and Survival Among Young Adults With Myocardial Infarction in the Partners YOUNG-MI Registry

Evaluation of Aspirin and Statin Therapy Use and Adherence in Patients With Premature Atherosclerotic Cardiovascular Disease

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