Risk factors and Pathogenesis in the Development of Prosthetic ValveEndocarditis

M.Phanindranath, Murtaza Mustafa.; Muniandy, Rajesh Kumar; Ibrahim, Magued; Musawwir, Raihana

doi:10.9790/3013-0408058064

Cited by 1 publication

(3 citation statements)

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“…Therefore, as a primary outcome of this study, a safety parameter was chosen including the combination of MACCE (death, stroke, myocardial infection) until discharge and endocarditis rate 6 months postoperatively. We found a cumulative primary outcome rate of 5.05% compared to 8.2% resulting from the data generated in the literature 8 , 9 . A t -test indicated that our MACCE rate+endocarditis rate was significantly lower.…”

Section: Discussionmentioning

confidence: 62%

“…Phanindranath and colleagues analyzed the risk factors and pathogenesis in the development of prosthetic valve endocarditis. According to the authors, the incidence of prosthetic valve endocarditis is highest during the first 6–12 months after surgery 9 . Therefore, we used the reported rate for this outcome parameter in our study for comparison at 6 months, after conducting a 6-month postsurgery examination in both participating clinics.…”

Section: Methodsmentioning

confidence: 99%

“…According to the literature data, the combined incidence of subsequent MACCEs: MI (1.9%), stroke (1.4%), mortality until discharge (1.4%) 8 , plus endocarditis of the replaced/reconstructed valve until 6 months (3.5%) 9 add up to 8.2% together.…”

Section: Methodsmentioning

confidence: 99%

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A prospective, international, bicentric study to evaluate PremiCron suture material for cardiac valve surgery – PREMIVALVE a cohort study

Rufa

Ursulescu

Baumann³

et al. 2023

Annals of Medicine &Amp; Surgery

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Introduction: The most common age-related heart valve diseases include aortic valve stenosis and mitral valve insufficiency. The suture material is not the focus of most studies. The aim of the study was to assess the performance of PremiCron suture material for cardiac valve reconstruction and/or replacement under clinical routine. Performance was evaluated using the incidence of major adverse cardiac and cerebrovascular events (MACCE) combined with endocarditis. Materials and methods: The study was designed as an international, prospective, bicentric, observational, single-arm study to evaluate the PremiCron suture material in cardiac valve surgery and compare the outcome with literature data regarding postoperative complications. The primary endpoint was a composite of MACCE acquired in the hospital, combined with endocarditis occurring up to 6 months postoperatively. The secondary parameters were intraoperative handling of the suture, incidence of MACCE and other relevant complications and quality of life up to 6 months after surgery. Patients were examined at discharge, 30 days, and 6 months postoperatively. Results: A total of 198 patients were enrolled in two centers in Europe. The cumulative primary endpoint event rate was 5.0%, lower than the reference value of 8.2% from the literature. Comparison of the incidence of individual MACCE until discharge and endocarditis rate 6 months postoperatively also showed that our data were within the range of the published rates. Quality of life significantly increased from preoperatively to 6 months after surgery. Ease of handling of the suture material was rated as very good. Conclusion: The PremiCron suture material is safe and very eligible for cardiac valve replacement and/or cardiac valve reconstruction in a broad patient population with a cardiac valve disorder treated under daily clinical practice.

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Section: Discussionmentioning

confidence: 62%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

A prospective, international, bicentric study to evaluate PremiCron suture material for cardiac valve surgery – PREMIVALVE a cohort study

Rufa

Ursulescu

Baumann³

et al. 2023

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

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Risk factors and Pathogenesis in the Development of Prosthetic ValveEndocarditis

Abstract: Mortality and morbidity in prosthetic valve endocarditis (PVE) is high despite improvements in

Cited by 1 publication

References 50 publications

A prospective, international, bicentric study to evaluate PremiCron suture material for cardiac valve surgery – PREMIVALVE a cohort study

A prospective, international, bicentric study to evaluate PremiCron suture material for cardiac valve surgery – PREMIVALVE a cohort study

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