Risk factors and pathogenesis of Hashimoto’s thyroiditis

Paknys, Gintaras; Kondrotas, Anatolijus Juozas; Kėvelaitis, Egidijus

doi:10.3390/medicina45070076

Cited by 12 publications

(10 citation statements)

References 32 publications

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“…For PBC on AITD, we define that PBC and AITD might be mutual cause-and-effect factors in both MR and reverse-direction MR analyses. Consistent with our findings, emerging epidemiological studies have shown that genetic components are important in the pathogenesis of Hashimoto's thyroiditis (Paknys et al, 2009). The occurrence of PBC and AITD might be caused by environmental and genetic factors, such as intestinal flora (Fenneman et al, 2020), estrogen (Qin et al, 2018), gene-mediated immunodeficiency, and synergy between each other (Milette et al, 2019).…”

Section: Discussionsupporting

confidence: 91%

The Causal Effects of Primary Biliary Cholangitis on Thyroid Dysfunction: A Two-Sample Mendelian Randomization Study

et al. 2021

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Background: Primary biliary cholangitis (PBC) is an autoimmune disease and is often accompanied by thyroid dysfunction. Understanding the potential causal relationship between PBC and thyroid dysfunction is helpful to explore the pathogenesis of PBC and to develop strategies for the prevention and treatment of PBC and its complications.Methods: We used a two-sample Mendelian randomization (MR) method to estimate the potential causal effect of PBC on the risk of autoimmune thyroid disease (AITD), thyroid-stimulating hormone (TSH) and free thyroxine (FT4), hyperthyroidism, hypothyroidism, and thyroid cancer (TC) in the European population. We collected seven datasets of PBC and related traits to perform a series MR analysis and performed extensive sensitivity analyses to ensure the reliability of our results.Results: Using a sensitivity analysis, we found that PBC was a risk factor for AITD, TSH, hypothyroidism, and TC with odds ratio (OR) of 1.002 (95% CI: 1.000–1.005, p = 0.042), 1.016 (95% CI: 1.006–1.027, p = 0.002), 1.068 (95% CI: 1.022–1.115, p = 0.003), and 1.106 (95% CI: 1.019–1.120, p = 0.042), respectively. Interestingly, using reverse-direction MR analysis, we also found that AITD had a significant potential causal association with PBC with an OR of 0.021 (p = 5.10E−4) and that the other two had no significant causal relation on PBC.Conclusion: PBC causes thyroid dysfunction, specifically as AITD, mild hypothyroidism, and TC. The potential causal relationship between PBC and thyroid dysfunction provides a new direction for the etiology of PBC.

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Section: Discussionsupporting

confidence: 91%

The Causal Effects of Primary Biliary Cholangitis on Thyroid Dysfunction: A Two-Sample Mendelian Randomization Study

et al. 2021

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“…PTC is the most common thyroid malignant tumor at present, which accounts for 70% ~ 80% of all thyroid cancers. In recent years, the incidence of PTC with HT is increasing [1,2,3] . An epidemiological study reported that PTC co-existed with PTC on average about 23% [9] , and in this study, this value was higher.…”

Section: Discussionmentioning

confidence: 99%

“…Hashimoto's thyroiditis (HT) is the most common autoimmune thyroid disease, also known as chronic lymphocytic or autoimmune thyroiditis [1,2] . In recent years, the incidence of HT has increased rapidly, especially in young and middle-aged women.HT can destroy thyroid tissue through cellular and antibody mediated immune processes and its main pathological features are lymphocytic infiltration, formation of lymphatic follicles, interstitial fibrosis, and destruction of normal thyroid tissue [2] .Laboratory tests of this disease are characterized by elevated thyroid peroxidase antibody(TPOAb) and thyroglobulin antibody(TGAb).With the progression of the disease, thyroid function can be roughly divided into three stages: normal, hyperactive and hypothyroidism. At first, thyroid function is usually normal or even hyperactive, but eventually it inevitably develops into hypothyroidism [3,4] .The diagnosis of HT requires a combination of clinical features, serum anti-thyroid antigen antibodies and sonographic findings.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonographic Characteristics Analysis of Papillary Thyroid Carcinoma with Hashimoto's Thyroiditis in Different Functional States

2022

IJFM

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The ultrasonographic characteristics of thyroid papillary carcinoma with and without hashimoto's thyroiditis were compared and analyzed to explore the effect of hashimoto's thyroiditis on ultrasonographic characteristics of thyroid papillary carcinoma, in order to improve the accuracy of ultrasonic diagnosis. Method 91 patients with thyroid papillary carcinoma confirmed by surgical resection and pathological biopsy in Beijing Chaoyang Hospital, Capital Medical University from September 2018 to November 2021 were retrospectively analyzed. Result The maximum diameter, blood flow grade and lymph node metastasis rate of papillary thyroid carcinoma in hashimoto's thyroiditis group were significantly higher than those in non-hashimoto thyroiditis group (P < 0.05). There were significant differences in the growth pattern, hardness and Ratio of papillary thyroid carcinoma among the three subgroups (P < 0.05). Conclusion Under different functional states, thyroid papillary carcinoma combined with hashimoto's thyroiditis showed differences in the growth pattern, hardness, blood grade and other sonographic characteristics.

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“…Autoimmune thyroid disease is predominantly the clinical expression of cell-mediated immunity, leading to the destruction of thyroid cells (Paknys et al, 2009). This is defined by the presence of Anti-TPO antibodies (thyroperoxidase) or Anti-thyroglobulin antibodies and high TSH concentrations in the absence of drugs.…”

Section: Discussionmentioning

confidence: 99%

Type III autoimmune polyglandular syndrome: association between Type 1 Diabetes mellitus and Hashimoto thyroiditis

Silvério

Bazuco

Merotti

et al. 2021

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Autoimmune polyglandular syndromes (APSS) are associations of two or more endocrine diseases of autoimmune origin that affect between 5-10% of the population. The grouping of these diseases depends on genetic and environmental factors, their different presentations allow the distinction of the subtypes of APS. The objective is to report the case of a patient with type III A polyglandular autoimmune syndrome, characterized by Hashimoto's thyroiditis and type 1 diabetes mellitus associated with hyperprolactinemia and Gilbert's syndrome. The patient began to show the symptoms of the syndrome at the age of 10 progressively. The treatment of each disease is being carried out, with no specific treatment for the syndrome in the literature.

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Risk factors and pathogenesis of Hashimoto’s thyroiditis

Cited by 12 publications

References 32 publications

The Causal Effects of Primary Biliary Cholangitis on Thyroid Dysfunction: A Two-Sample Mendelian Randomization Study

The Causal Effects of Primary Biliary Cholangitis on Thyroid Dysfunction: A Two-Sample Mendelian Randomization Study

Ultrasonographic Characteristics Analysis of Papillary Thyroid Carcinoma with Hashimoto's Thyroiditis in Different Functional States

Type III autoimmune polyglandular syndrome: association between Type 1 Diabetes mellitus and Hashimoto thyroiditis

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