Risk Factors and Pathogens of Wound Infection in Burn Inpatients from East China

Abstract

Background: Infection is the predominant contributor to morbidity and mortality in burn patients, and burn wound infection (BWI) is the most common reason. The objective of this research was to analyze the incidence, factors and progression of BWI, in terms of events and bacteria. Methods: Clinical variables of all qualified patients admitted to burn wards were analyzed retrospectively in 2021 at a tertiary hospital in eastern China through univariate analysis and multivariate logistic regression. The Kaplan–Meier method was also used for plotting survival curves. Isolates and resistance data were evaluated to demonstrate the evolution of targeted antibiotics of strains from BWI. Results: A total of 580 (median age, 39.5 years (23–56 years); 372/580 (64.14%) male) patients were evaluated, 348 (60.0%) of whom experienced BWI. A variety of factors are associated with BWI. Multivariate logistic regression analysis showed that depth and area of burn and duration from burn to first hospitalization are independent risk factors for BWI. For BWI onset in these patients, 47.24% (274/580) occurred in the first week. The most frequently isolated causative organism was Staphylococcus aureus (15.7%) in patients with BWI. The duration of transition from Gram-positive strains (median 3 days, (2–7 days)) to Gram-negative (median 10 days, (4–17 days)) ones isolated from burn wound shrunk. Hospital length of stay was considered as a protective factor for BWI. Conclusion: The precise assessment of factors affecting BWI in burn patients enhances prompt and suitable management. Swab cultures for surveillance could be utilized to monitor the microbiological status of burn patients.

Distribution of Nosocomial Pathogens and Antimicrobial Resistance among Patients with Burn Injuries in China: A Comprehensive Research Synopsis and Meta-Analysis

“…[ 27 ] 2016–20 Henan Tertiary Unclear 1902 584 278 69 137 124 7 Zhou et al. [ 13 ] 2021 Shanghai Tertiary 348 649 102 55 69 69 92 8 Han et al. [ 28 ] 2010–23 Shaanxi Tertiary 216 245 101 54 33 8 - 6 Hu and Lu [ 29 ] 2020–22 Jiangsu Tertiary Unclear 1167 215 292 192 247 – 6 Han and Zhang [ 30 ] 2015–20 Chongqing Tertiary 833 833 134 103 65 63 49 7 Li et al.…”

“…The colonization patterns of pathogens that cause burn infections may vary owing to differences in geographical, climatic and environmental factors, hospital management practices and the duration of hospitalization. A study conducted in Morocco identified Acinetobacter baumannii and Pseudomonas aeruginosa as the most common pathogens among patients with burn infection, while studies in China revealed that Staphylococcus aureus and Staphylococcus epidermidis were the most prevalent pathogens isolated from patients with burn injuries [ 13 , 14 ].…”

“…Clinicians must rationally prescribe antibiotics and formulate strategies to avoid antimicrobial resistance in patients with burn injuries. Although the regional compositions of burn infection pathogens and antibiotic resistance have been studied in China, comprehensive reports on the overall situation with pathogen infections and resistance among individuals suffering from burns in China are lacking [ 13 , 18 ]. This study aimed to evaluate and summarize the pathogen infection status among individuals suffering from burns in China and provide a synopsis of our current understanding of the infection spectrum and antimicrobial resistance patterns in patients with burn injuries.…”

Biofilm generation and antibiotic resistant profile of extensive and multidrug resistant Pseudomonas aeruginosa from burn patients in Ahvaz: A cross‐sectional study

“…By the growth of microorganisms in the initially‐sterile burn wounds, infection would then occur depending on the wound's nature and extension and microorganism's species and number. 4 Pseudomonas aeruginosa as a leading factor in the induction of serious infections over the wound. 5 P. aeruginosa is indeed among the top 10 virulent nosocomial pathogens worldwide.…”