Risk Factors and Predictors of Refractory Childhood Epilepsy: Case Control Study

Ismail, Taghreed A.M.; El-Deen, Mohammed Salah; Hammad, Emad El-Deen M.; Metwally, Kotb A.

doi:10.21608/mjcu.2018.56755

Cited by 6 publications

(9 citation statements)

References 7 publications

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“…Ayca and colleagues [ 11 ] also found that abnormal neurological examination was 58 times more in drug-resistant epilepsy and was the most important risk factor, possibly reflecting the severity of brain damage. The presence of abnormal neurological examination agrees with other studies [ 10 , 17 ]. Drug-resistant epilepsy has been linked to a history of psychiatric comorbidity, particularly depression, according to Hitiris and colleagues [ 14 ].…”

Section: Discussionsupporting

confidence: 92%

“…This is consistent with Ayca and colleagues [ 11 ], who showed that a positive family history of seizures did not seem to be a risk factor for drug-resistant epilepsy. Other studies found no significant correlation between a family history of seizures and drug-resistant epilepsy [ 10 , 12 , 13 ]. Twin studies suggested that genes and, therefore, family history may have a role in the pathophysiology of epilepsy but not in its prognosis [ 14 ].…”

Section: Discussionmentioning

confidence: 90%

“…Besides, the history of delayed milestones and perinatal insult was a predictor of drug resistance [ 9 ]. The association between developmental delay and negative outcomes may result from minor but widespread brain anatomical abnormalities [ 10 ]. Hypoxic or asphyxic events, mainly in the perinatal period, promote epileptogenesis and are important in developing drug resistance [ 11 ]…”

Section: Discussionmentioning

confidence: 99%

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Clinical, radiological and electrophysiological predictors for drug-resistant epilepsy

Abokrysha

Taha

Shamloul

et al. 2023

Egypt J Neurol Psychiatry Neurosurg

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Background Epilepsy is the third chronic brain illness worldwide. About a third of the epileptic patients will be drug resistant. Early identification of these patients is critical for appropriate treatment selection and prevention of the devastating consequences of recurrent seizures. The objective of this study aims to detect clinical, electrophysiological, and radiological predictors for drug-resistant epilepsy patients. Results One hundred fifty-five patients were included in this study, divided into a well-controlled epilepsy group (103 patients) and a drug-resistant group (52 patients). Both groups were compared regarding clinical, electrophysiological, and neuro-radiological data. Younger age at onset, history of delayed milestones, history of perinatal insult (especially hypoxia), mental retardation, neurological deficits, depression, status epilepticus (SE), complex febrile seizures, focal seizure to bilateral tonic–clonic convulsion as well as multiple seizures and high seizure frequency (daily) at onset, poor response to first anti-seizure drug (ASD), structural and metabolic etiology, abnormal brain imaging, and slow background and multifocal epileptiform discharges in EEG were significant risk factors for the development of drug-resistant epilepsy. Conclusion MRI abnormalities are the most significant predictor for drug-resistant epilepsy. Drug-resistant epilepsy is associated with clinical, electrophysiological, and radiological risk factors that can be used to diagnose drug-resistant patients early and choose the best treatment option and time.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical, radiological and electrophysiological predictors for drug-resistant epilepsy

Abokrysha

Taha

Shamloul

et al. 2023

Egypt J Neurol Psychiatry Neurosurg

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“…Recurrent fits are demonstrated to be accompanied by neuronal loss especially in the hippocampal area, that could ultimately ends in recurrent excitatory circuits [8] . Likewise, El-Deen et al [9] displayed that past history of febrile seizures were significantly increased among cases with DRE than those with responsive epilepsy. In contrast, Ohtsuka et al [10] recorded no correlation between febrile seizures and DRE.…”

Section: Discussionmentioning

confidence: 96%

“…In regard to seizure frequency, the current study demonstrated higher frequency of seizures per weeks before start of treatment (p=0.03). Likewise, El-Deen et al [9] recorded that high initial seizure frequency was a significant predisposing factor of DRE.…”

Section: Discussionmentioning

confidence: 97%

Predictive Factors of Refractory Epilepsy

2024

The Egyptian Journal of Hospital Medicine

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Background: Several epileptic patients give no response to the usual line of treatment, which represents 1/5 of epileptic patients and is known as drug-resistant epilepsy (DRE). DRE is often accompanied by impaired intellectual functions, psychiatric co-morbidities, physical damage, and low quality of life (QoL).Objective: This study aimed to assess the predictive factors for early identification of refractory seizures. Patients and Methods: This was a cross-section study conducted during a period of one year at Emergency Department (ED), Faculty of Medicine, Mansoura University. We comprised cases with diagnosis of refractory epilepsy on a total of 80 patients with refractory seizures [at least 2 potentially effective anti-epileptic drugs (AEDs) whatever mono or combined in maximally tolerated dose]. Results: Of the studied cases, 62.5% were females. There was a significant difference in cases with refractory epilepsy as regard seizures types with higher frequency of mixed and focal seizures. There was no statistically significant difference recorded regarding the previous history of status epilepticus (SE). Mixed seizures were significantly increased among cases with refractory epilepsy. The presence of positive family history, positive history of febrile seizures, associated psychiatric disorders and younger age at disease onset increase risk of refractory epilepsy. Conclusion:The main predictors of development of DRE were high initial seizures frequency, positive family history, febrile seizures, associated psychiatric disorders and younger age at disease onset.

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Pharmacogenetic study of phosphatase and tensin homolog polymorphism (rs701848) in childhood epilepsy: relation to circulating Wnt signaling

Hassan,

Nassar,

Meki

et al. 2023

Neurological Research

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Risk Factors and Predictors of Refractory Childhood Epilepsy: Case Control Study

Abstract: Background: Each year, 3.5 million new cases of epilepsy are reported. Unfortunately, 6-14% of these children will develop refractory epilepsy.

Cited by 6 publications

References 7 publications

Clinical, radiological and electrophysiological predictors for drug-resistant epilepsy

Clinical, radiological and electrophysiological predictors for drug-resistant epilepsy

Predictive Factors of Refractory Epilepsy

Pharmacogenetic study of phosphatase and tensin homolog polymorphism (rs701848) in childhood epilepsy: relation to circulating Wnt signaling

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