Risk factors and prognosis after discharge for patients admitted because of suspected acute myocardial infarction with and without confirmed diagnosis

Madsen, Jan Kyst; Thomsen, Birthe Lykke; Sørensen, Jan; Kjeldgaard, Karen Marie; Kromann‐Andersen, Bjarne

doi:10.1016/0002-9149(87)90849-6

Cited by 39 publications

(29 citation statements)

References 11 publications

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“…Diabetic patients have an increased risk of developing myocardial infarction, making the proportion of diabetic patients in a myocardial infarction population 10-20% [5][6][7] . In the present study we found 10·8% of consecutive patients with myocardial infarction to have diabetes defined by history.…”

Section: Demographic Datamentioning

confidence: 99%

“…No registration of diabetes diagnosed during the hospital stay was done, which is a limitation of this analysis. When employing an oral glucose tolerance test in patients without known diabetes, a further 5% of myocardial infarction patients are likely to be diagnosed as having diabetes mellitus [5,14] .…”

Section: Demographic Datamentioning

confidence: 99%

“…Hence, diabetes mellitus is associated with a higher incidence of acute myocardial infarction [3,4] . Among patients admitted with myocardial infarction, the proportion of diabetic patients is at least 10% [5][6][7] the majority of which have type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, diabetic patients have a substantially higher mortality rate after acute myocardial infarction than non-diabetic patients [5,[7][8][9] which has partly been attributed to the development of heart failure [7][8][9] . Although many studies on diabetes and ischaemic heart disease have already been carried out there are several shortcomings in the available information on prognostic factors in diabetic patients with myocardial infarction.…”

Section: Introductionmentioning

confidence: 99%

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Long-term prognosis of diabetic patients with myocardial infarction: relation to antidiabetic treatment regimen

Gustafsson

Hildebrandt²,

Seibæk³

et al. 2000

European Heart Journal

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AimsThe present study was performed to evaluate pre-admission history, presentation, initial treatment and long-term mortality in patients with myocardial infarction and diabetes. Between 1990 and 1992, 6676 patients with acute myocardial infarction were screened for entry into the Trandolapril Cardiac Evaluation (TRACE) study. In this cohort 719 (11%) of the patients had a history of diabetes. Among the diabetic patients 19% were treated with insulin, 52% with oral hypoglycaemic agents and 29% with diet only. The diabetic patients were slightly older, more likely to be female and had a higher prevalence of known cardiovascular disease. Even though the diabetic patients had the same frequency of ST-segment elevation on the electrocardiogram and the same admission delay, treatment with thrombolysis and aspirin was less frequently prescribed to the diabetic patients than to patients without diabetes. The mortality rate was significantly increased in the diabetic patients, 7-year mortality being 79% in insulintreated, 73% in tablet-treated and 62% in diet-treated diabetic patients compared with 46% in patients without diabetes. In a multivariate analysis only diabetic patients treated with oral hypoglycaemic agents or with insulin had an increased mortality compared with non-diabetic patients. Methods and Results ConclusionsPatients with diabetes mellitus and myocardial infarction are treated with thrombolysis to a lesser extent than non-diabetic patients. Diabetic patients treated with oral hypoglycaemic agents or insulin, but not those treated with diet alone, have a significantly increased mortality following acute myocardial infarction compared with non-diabetic patients.

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Section: Demographic Datamentioning

confidence: 99%

Section: Demographic Datamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Long-term prognosis of diabetic patients with myocardial infarction: relation to antidiabetic treatment regimen

Gustafsson

Hildebrandt²,

Seibæk³

et al. 2000

European Heart Journal

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show abstract

“…Myocardial cell death can be predicted by the appearance of proteins that are generated by the damaged myocytes (1). Mortality rates of diabetic patients due to acute myocardial infarction are significantly higher compared to nondiabetic patients, posing a serious threat to diabetics (2)(3)(4). Persistent hyperglycemia leads to the development of atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Stress-responsive factor regulation in patients suffering from type 2 diabetes and myocardial infarction

Mushtaq¹,

Ali²,

Altaf³

et al. 2015

Turk J Med Sci

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Background/aim: Pro-free radical oxidative stresses, as well as regulatory factors, are believed to be the key players in the development of diabetes and heart-related disorders such as myocardial infarction. The aim of the present study was to highlight the role of oxidative stress-responsive factors (reactive oxygen species [ROS], super oxide dismutase [SOD], and calpain-1) in type 2 diabetes and myocardial infarction.Materials and methods: A total of 100 type 2 diabetes patients with myocardial infarction and 50 normal individuals were selected for this analysis. The levels of ROS and activities of SOD in the serum were determined. Serum calpain-1 expression was checked using western blotting. Results:The serum level of ROS and the expression of calpain-1 were significantly higher while the activity of SOD was significantly lower in diabetic patients with myocardial infraction compared to normal individuals. Conclusion:These findings suggest a possible link between decreased antioxidant (SOD) and increased ROS levels as well as calpain-1 expression, supporting the role of oxidative stress-regulatory factors in diabetes and myocardial infraction.

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Prognosis, severity of symptoms, and aspects of well‐being among patients in whom myocardial infarction was ruled out

Karlson

M.Sc.²,

Bengtson

et al. 1994

Clinical Cardiology

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Summary:In a high proportion of patients hospitalized due to suspected acute myocardial infarction (AMI) the diagnosis cannot be confirmed. The majority of these patients have ischemic heart disease and are at risk for subsequent cardiac events. The a i m of this study was to describe the severity of symptoms and various aspects of well-being 1 year after hospitahzation due to suspected AMI in surviving patients in whom the diagnosis was not confirmed, and to relate the observations to those found among survivors of a confirmed AMI. All patients admitted to Sahlgrenska Hospital, Goteborg, due to suspected AM1 and who were alive after 1 year were asked to answer a questionnaire including questions regarding cardiovascular, psychiatric, and psychological symptoms. Patients in whom AMI was not confmed reported more cardiovascular symptoms, for example, chest pain (p < 0.001), dyspnea (p <0.01), palpitations (p < 0.00 l), and fatigue (p < 0.01) when compared with patients who suffered confiied AMI. The majority of psychosomatic and psychological parameters evaluated were also more frequently reported by these patients and their quality of life seems to be worse compared with survivors of AMI.

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Risk factors and prognosis after discharge for patients admitted because of suspected acute myocardial infarction with and without confirmed diagnosis

Cited by 39 publications

References 11 publications

Long-term prognosis of diabetic patients with myocardial infarction: relation to antidiabetic treatment regimen

Long-term prognosis of diabetic patients with myocardial infarction: relation to antidiabetic treatment regimen

Stress-responsive factor regulation in patients suffering from type 2 diabetes and myocardial infarction

Prognosis, severity of symptoms, and aspects of well‐being among patients in whom myocardial infarction was ruled out

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