2021
DOI: 10.2147/idr.s317233
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Risk Factors and Prognosis of Carbapenem-Resistant Klebsiella pneumoniae Infections in Respiratory Intensive Care Unit: A Retrospective Study

Abstract: Purpose Carbapenem-resistant Klebsiella pneumoniae (CRKP) infections have become a serious threat with high morbidity and mortality. Early identification of risk factors for CRKP infections is important, but these factors are still controversial. Therefore, we aimed to identify the risk factors and clinical outcomes of CRKP infections. Patients and Methods The retrospective, single-center study was carried out in the respiratory intensive care… Show more

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Cited by 16 publications
(20 citation statements)
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“…Horizontal transfer of mobile genetic elements (MGE) promoted the spread and transmission of CRKP. According to China Antimicrobial Surveillance Network (CHINET), the prevalence of CRKP (defined by resistance to any of the carbapenems) increased from 3.0% in 2005 to 20.9% in 2017 in China ( 3 ). Infections caused by CRKP mainly occurred in health care settings and have high rates of morbidity and mortality due to the scarcity of effective treatments ( 4 ).…”
Section: Introductionmentioning
confidence: 99%
“…Horizontal transfer of mobile genetic elements (MGE) promoted the spread and transmission of CRKP. According to China Antimicrobial Surveillance Network (CHINET), the prevalence of CRKP (defined by resistance to any of the carbapenems) increased from 3.0% in 2005 to 20.9% in 2017 in China ( 3 ). Infections caused by CRKP mainly occurred in health care settings and have high rates of morbidity and mortality due to the scarcity of effective treatments ( 4 ).…”
Section: Introductionmentioning
confidence: 99%
“…Among the bacteria producing beta-lactamases, the genus Klebsiella spp, Escherichia spp, Enterobacter spp, Salmonella spp, Serratia spp, Citrobacter spp, Proteus spp, and Morganella stand out. The genes responsible for encoding the most prevalent carbapenemases are from the bla KPC, bla VIM, bla IMP, bla Oxa, and bla Ndm groups [ 16 ].…”
Section: Discussionmentioning
confidence: 99%
“…K. pneumoniae strains that produce ESBL are found all over the world, causing numerous outbreaks of infections. Bloodstream infections caused by K. pneumoniae can occur because of ventilator-acquired pneumonia or through social contact, through the urinary system, intra-abdominal diseases, and central venous line infections [ 16 , 17 , 18 , 19 ].…”
Section: Discussionmentioning
confidence: 99%
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