Risk factors and prognosis of orbital exenteration in conjunctival melanoma

Zong, Chunyan; Jia, Shichong; Zhu, Tianyu; Shi, Hanhan; Tian, Hao; Li, Yimin; Jia, Renbing; Xu, Shi-Qiong

doi:10.1038/s41433-022-02330-w

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…Despite advancements in diagnostic and treatment modalities, clinical outcome of CoM continues to be unsatisfactory due to frequent occurrence of distant metastasis, even following orbital exenteration surgery 32 . Considering the distinct genetic backgrounds and mutational profiles observed in cutaneous, uveal, and conjunctival melanoma, it is imperative to modify therapeutic approaches based on the specific genetic characteristics of each subtype.…”

Section: Discussionmentioning

confidence: 99%

Single-cell sequencing depicts tumor architecture and empowers clinical decision in metastatic conjunctival melanoma

Shi,

Tian,

Zhu

et al. 2024

Cell Discov

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Conjunctival melanoma (CoM) is a potentially devastating tumor that can lead to distant metastasis. Despite various therapeutic strategies for distant metastatic CoM, the clinical outcomes remain unfavorable. Herein, we performed single-cell RNA sequencing (scRNA-seq) of 47,017 cells obtained from normal conjunctival samples (n = 3) and conjunctival melanomas (n = 7). Notably, we noticed a higher abundance of cancer-associated fibroblasts (CAFs) in tumor microenvironment (TME), correlated with enhanced angiogenic capacity and increased VEGFR expression in distal metastatic CoM. Additionally, we observed a significant decrease in the proportion of total CD8+ T cells and an increase in the proportion of naive CD8+ T cells, contributing to a relatively quiescent immunological environment in distal metastatic CoM. These findings were confirmed through the analyses of 70,303 single-cell transcriptomes of 7 individual CoM samples, as well as spatially resolved proteomes of an additional 10 samples of CoMs. Due to the increase of VEGFR-mediated angiogenesis and a less active T cell environment in distal metastatic CoMs, a clinical trial (ChiCTR2100045061) has been initiated to evaluate the efficacy of VEGFR blockade in combination with anti-PD1 therapy for patients with distant metastatic CoM, showing promising tumor-inhibitory effects. In conclusion, our study uncovered the landscape and heterogeneity of the TME during CoM tumorigenesis and progression, empowering clinical decisions in the management of distal metastatic CoM. To our knowledge, this is the initial exploration to translate scRNA-seq analysis to a clinical trial dealing with cancer, providing a novel concept by accommodating scRNA-seq data in cancer therapy.

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Section: Discussionmentioning

confidence: 99%

Single-cell sequencing depicts tumor architecture and empowers clinical decision in metastatic conjunctival melanoma

Shi,

Tian,

Zhu

et al. 2024

Cell Discov

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A Case of Conjunctival Melanoma Presenting as a Squamous Cell Carcinoma

Menna,

Tschopp,

Meyer

et al. 2024

Case Rep Ophthalmol

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Introduction: Conjunctival melanoma (CM) is a rare but potentially lethal ocular malignancy that arises from melanocytes in the conjunctiva. Its clinical presentation can mimic other more common conjunctival lesions, such as squamous cell carcinoma (SCC), leading to diagnostic challenges. Case Presentation: We present a case of CM initially misdiagnosed as conjunctival SCC due to overlapping clinical features. Conclusion: CM presenting as nonpigmented, conjunctival tumor is a diagnostic challenge. Clinicians should maintain a high index of suspicion for conjunctival melanocytic or amelanotic lesions, particularly those with atypical features.

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Risk factors and prognosis of orbital exenteration in conjunctival melanoma

Cited by 2 publications

References 32 publications

Single-cell sequencing depicts tumor architecture and empowers clinical decision in metastatic conjunctival melanoma

Single-cell sequencing depicts tumor architecture and empowers clinical decision in metastatic conjunctival melanoma

A Case of Conjunctival Melanoma Presenting as a Squamous Cell Carcinoma

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