Risk factors and prognostic value of daytime Cheyne–Stokes respiration in chronic heart failure patients

Poletti, Roberta; Passino, Claudio; Giannoni, Alberto; Zyw, Luc; Prontera, Concetta; Bramanti, Francesca; Clerico, A.; Piepoli, Massimo F; Emdin, Michele

doi:10.1016/j.ijcard.2008.06.028

Cited by 58 publications

(48 citation statements)

References 33 publications

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“…CREB A133 mice demonstrated elevations in basal respiratory rates and minute ventilation compared with CD1 mice (Figure 2A), but prominent respiratory instability after PM challenge manifested as a periodic breathing pattern, a prognostic sign for the sudden cardiac decompensation and death often observed in patients with severe CHF (30,32,33). Respiratory dysynchrony was more pronounced during hypoxia ( Figure 2B) and was abolished by carotid body denervation ( Figure 2C), which also significantly reduce PM-mediated cardiac arrhythmias in CREB A133 mice ( Figure 2D).…”

Section: Pm Mediates Heightened Carotid Body Sensitivity and Autonomimentioning

confidence: 99%

Particulate Matter Induces Cardiac Arrhythmias via Dysregulation of Carotid Body Sensitivity and Cardiac Sodium Channels

Wang¹,

Lang²,

Moreno‐Vinasco³

et al. 2012

Am J Respir Cell Mol Biol

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The mechanistic links between exposure to airborne particulate matter (PM) pollution and the associated increases in cardiovascular morbidity and mortality, particularly in people with congestive heart failure (CHF), have not been identified. To advance understanding of this issue, genetically engineered mice (CREB A133 ) exhibiting severe dilated cardiomyopathic changes were exposed to ambient PM collected in Baltimore. CREB A133 mice, which display aberrant cardiac physiology and anatomy reminiscent of human CHF, displayed evidence of basal autonomic aberrancies (compared with wild-type mice) with PM exposure via aspiration, producing significantly reduced heart rate variability, respiratory dysynchrony, and increased ventricular arrhythmias. Carotid body afferent nerve responses to hypoxia and hyperoxia-induced respiratory depression were pronounced in PM-challenged CREB A133 mice, and denervation of the carotid bodies significantly reduced PM-mediated cardiac arrhythmias. Genome-wide expression analyses of CREB A133 left ventricular tissues demonstrated prominent Na 1 and K 1 channel pathway gene dysregulation. Subsequent PM challenge increased tyrosine phosphorylation and nitration of the voltage-gated type V cardiac muscle a-subunit of the Na 1 channel encoded by SCN5A. Ranolazine, a Na 1 channel modulator that reduces late cardiac Na 1 channel currents, attenuated PM-mediated cardiac arrhythmias and shortened PMelongated QT intervals in vivo. These observations provide mechanistic insights into the epidemiologic findings in susceptibility of human CHF populations to PM exposure. Our results suggest a multiorgan pathobiology inherent to the CHF phenotype that is exaggerated by PM exposure via heightened carotid body sensitivity and cardiac Na 1 channel dysfunction.

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Section: Pm Mediates Heightened Carotid Body Sensitivity and Autonomimentioning

confidence: 99%

Particulate Matter Induces Cardiac Arrhythmias via Dysregulation of Carotid Body Sensitivity and Cardiac Sodium Channels

Wang¹,

Lang²,

Moreno‐Vinasco³

et al. 2012

Am J Respir Cell Mol Biol

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“…Periodic breathing (PB) patterns can be classified into ventilation with apnea, known as Cheyne-Stokes respiration (CSR), and ventilation without apnea [3], [4]. PB has a prevalence as high as 70% in CHF patients [5], and is associated with increased mortality [6], especially in CSR patients [7], [8]. The breathing patterns are also influenced by wakefulness or sleep, posture, as well as physiological and mental activity [9].…”

mentioning

confidence: 99%

Correntropy-Based Spectral Characterization of Respiratory Patterns in Patients With Chronic Heart Failure

Garde

Sörnmo

Jané

et al. 2010

IEEE Trans. Biomed. Eng.

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Abstract-A correntropy-based technique is proposed for the characterization and classification of respiratory flow signals in chronic heart failure (CHF) patients with periodic or nonperiodic breathing (PB or nPB, respectively) and healthy subjects. The correntropy is a recently introduced, generalized correlation measure whose properties lend themselves to the definition of a correntropybased spectral density (CSD). Using this technique, both respiratory and modulation frequencies can be reliably detected at their original positions in the spectrum without prior demodulation of the flow signal. Single-parameter classification of respiratory patterns is investigated for three different parameters extracted from the respiratory and modulation frequency bands of the CSD, and one parameter defined by the correntropy mean. The results show that the ratio between the powers in the modulation and respiratory frequency bands provides the best result when classifying CHF patients with either PB or nPB, yielding an accuracy of 88.9%. The correntropy mean offers excellent performance when classifying CHF patients versus healthy subjects, yielding an accuracy of 95.2% and discriminating nPB patients from healthy subjects with an accuracy of 94.4%.

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“…Moreover, Poletti et al evaluated neurohormonal derangement among 147 HF patients with and without CSA and found a higher plasma norepinephrine (NE) in CSA (588 vs. 331 pg/ mL, P=0.01] and natriuretic peptides B (BNP) (284 vs. 164 pg/ml) and NT-proBNP (2575 vs. 448 pg/mL, P=0.001) as compared with No SDB [12]. Cardiac natriuretic hormone production is elicited in response to ventricular volume expansion and pressure overload, which have been associated with presence of sleep-related central apneas, sympathetic activation, and hypoxia [12].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Human Natriuretic Peptides (B), Human N-Terminal Pro-BNP and Nor-epinephrine as Neurohumoral Markers in Sleep Disordered Breathing among Heart Failure Patients in Upper Egypt

Salama¹,

Omar²,

Sabour³

et al. 2017

J Clin Trials

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Risk factors and prognostic value of daytime Cheyne–Stokes respiration in chronic heart failure patients

Abstract: Daytime CS is frequent in CHF and is correlated with clinical severity, neurohormonal derangement, particularly of NT-proBNP, and long-term prognosis.

Cited by 58 publications

References 33 publications

Particulate Matter Induces Cardiac Arrhythmias via Dysregulation of Carotid Body Sensitivity and Cardiac Sodium Channels

Particulate Matter Induces Cardiac Arrhythmias via Dysregulation of Carotid Body Sensitivity and Cardiac Sodium Channels

Correntropy-Based Spectral Characterization of Respiratory Patterns in Patients With Chronic Heart Failure

Assessment of Human Natriuretic Peptides (B), Human N-Terminal Pro-BNP and Nor-epinephrine as Neurohumoral Markers in Sleep Disordered Breathing among Heart Failure Patients in Upper Egypt

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