Risk Factors and Psychological Analysis of Chronic Immune Thrombocytopenia in Children

Sun, Ying; Long, Sili; Chen, Li

doi:10.2147/ijgm.s290459

Cited by 6 publications

(5 citation statements)

References 35 publications

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“…The findings also indicate that there was no significant association between sex, age, and the type of ITP or bleeding manifestations. A retrospective study on children with ITP, similar to our registry, found no statistically significant difference in gender between chronic and non-chronic ITP cases [ 23 ].…”

Section: Discussionmentioning

confidence: 70%

The first national pediatric immune thrombocytopenia registry in Iran: research protocol and preliminary study results

Kamfar,

Haghi,

Zeinali

et al. 2024

BMC Health Serv Res

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Background Disease registries are comprehensive databases that record detailed information on patients diagnosed with specific conditions, providing valuable insights into their diagnosis, treatment, and outcomes. This study aims to describe the pilot phase of the national pediatric Immune Thrombocytopenia(ITP) registry (NPITP) in Iran, serving as the inaugural interpretive report. Methods This patient-centered software system was implemented as a national program across multiple pediatric centers in Iran. Several focus groups were conducted to establish a minimum data set (MDS) comprising six main classes, 14 sub-classes, and 187 data elements. Following expert consensus on the final data set, a web-based software tool was developed by the dedicated IT team, accessible online and offline via https://disreg.sbmu.ac.ir/q/ITP.html. The registry included children aged between two months and 18 years with a platelet count below 100 × 109/L, based on predefined inclusion criteria. Results Within a four-month period, a total of 60 ITP patients were registered, including 41 (68.3%) newly diagnosed cases, 68 (13.6%) persistent cases, and 14 (23.3%) with chronic ITP. The mean age of the registered patients was 55.93 ± 9.72 months. The most frequently observed bleeding symptoms were petechiae (68.3%), purpura (51.6%), and ecchymosis (13.3%). Among the newly diagnosed patients, 20 (33.3%) received intravenous immunoglobulin (IVIG), 17 (28.3%) were treated with prednisolone, and 17 (28.3%) received combined IVIG and steroid therapy. Of all patients, 40 (66.7%) demonstrated a complete response to treatment, while 16 (26.7%) exhibited a partial response. Four patients (6.7%) remained unresponsive to therapy. Treatment-related complications, such as Cushing’s syndrome, edema, weight gain, hirsutism, and mood disorders, were reported in 10 patients (16.6%). However, the majority of patients (81.7%) did not experience therapy-related complications. Conclusion The pilot phase of the NPITP registry successfully implemented a web-based software tool for data collection, aiming to enhance the quality of care, facilitate clinical research, and support health service planning in the future.

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Section: Discussionmentioning

confidence: 70%

The first national pediatric immune thrombocytopenia registry in Iran: research protocol and preliminary study results

Kamfar,

Haghi,

Zeinali

et al. 2024

BMC Health Serv Res

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“…Given the high treatment failure rate, it is important to identify risk factors for relapse and predictors of response to therapy. Previously, an elevated ferritin level, positivity for Hepatitis B Surface Antigen (HBsAg) or for antinuclear antibody (ANA), platelet counts ≥ 20 ×10 9 /L and older age were identi ed as adverse factors for adult ITP relapse and response to treatment outcomes[18, 20, 21], while age > 6 yrs, higher platelet count at diagnosis and lower absolute lymphocyte count were identi ed as adverse risk factors in pediatric ITP outcomes [22,23]. Results of our study suggest that obesity may also be a risk factor for diagnosis and relapse in adults.…”

Section: Discussionmentioning

confidence: 99%

Obesity is associated with adverse outcomes in primary immune thrombocytopenia- A retrospective single-center study

Xiao,

He,

Nguyen

et al. 2024

Preprint

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The pathophysiology of immune thrombocytopenia (ITP) involves immune-mediated platelet destruction. The presence of adipose tissue in obese individuals creates an inflammatory environment that could potentially impact the clinical course and outcomes of ITP. However the relationship between obesity and ITP outcomes has not been well described. We evaluated ITP outcomes in 275 patients diagnosed with primary ITP from 2012 to 2022. Patients were categorized into four groups based on their body mass index (BMI) at diagnosis. Female gender was associated with a lower platelet count at the time of diagnosis at any BMI. Patients with high BMI had lower platelet counts at diagnosis and at platelet nadir (p < 0.001), an increased likelihood of requiring therapy (p < 0.001) and requiring multiple lines of therapy (p = 0.032). Non-obese patients who required corticosteroid treatment experienced a longer remission duration compared to obese patients (p = 0.009) and were less likely to be steroid-dependent (p = 0.048). Our findings suggest that obesity may be a significant risk factor for developing ITP and for ITP prognosis. Future studies are needed to evaluate the role of weight loss intervention in improving ITP outcomes.

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“…Given the high treatment failure it is important to identify risk factors for relapse and predictors of response to therapy. Previously, an elevated ferritin level, positivity for Hepatitis B Surface Antigen (HBsAg) or for antinuclear antibody (ANA), platelet counts ≥ 20 ×10 9 /L and older age were identi ed as adverse factors for adult ITP relapse and response to treatment outcomes[18, 20, 21], while age > 6 yrs, higher platelet count at diagnosis and lower absolute lymphocyte count were identi ed as adverse risk factors in pediatric ITP outcomes [22,23]. Results of our study suggest that obesity may also be a risk factor for diagnosis and relapse in adults.…”

Section: Discussionmentioning

confidence: 99%

Obesity is Associated with Adverse Outcomes in Primary Immune Thrombocytopenia - A Retrospective Single-Center Study

Xiao,

He,

Le Nguyen

et al. 2024

Preprint

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Risk Factors and Psychological Analysis of Chronic Immune Thrombocytopenia in Children

Cited by 6 publications

References 35 publications

The first national pediatric immune thrombocytopenia registry in Iran: research protocol and preliminary study results

The first national pediatric immune thrombocytopenia registry in Iran: research protocol and preliminary study results

Obesity is associated with adverse outcomes in primary immune thrombocytopenia- A retrospective single-center study

Obesity is Associated with Adverse Outcomes in Primary Immune Thrombocytopenia - A Retrospective Single-Center Study

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