Risk factors and the utility of three different kinds of prediction models for postoperative fatigue after gastrointestinal tumor surgery

Xu, Xinyi; Lu, Jinling; Xu, Qin; Hua, Hongxia; Xu, Lianjun; Chen, Li

doi:10.1007/s00520-020-05483-0

Cited by 20 publications

(10 citation statements)

References 27 publications

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“…In addition to in ammatory parameters, their signi cant differences were observed in sleep disorder and postoperative depression between POF and non-POF groups. The results were consistent with those of previously published studies, indicating that mental health-related factors play an important role in the occurrence and development of POF 2,24 .…”

Section: Discussionsupporting

confidence: 93%

Association Between Neutrophil-To-Lymphocyte Ratio and Postoperative Fatigue in Elderly Patients with Hip Fracture

Jing

Wang

Chen

et al. 2022

Preprint

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Background and purpose: Postoperative fatigue (POF) is a common and distressing post-operative symptom. This study aimed to explore the relationship between neutrophil-to-lymphocyte ratio (NLR) and POF in elderly patients with hip fracture.Method: Elderly patients (age ≥ 65 years) with acute hip fracture admitted to the Department of Orthopedics of Anqing Hospital affiliated to Anhui Medical University from June 2018 to June 2020 were included. Fatigue was assessed using the Fatigue Severity Scale at the 3-month follow-up postoperatively. Univariate and multivariate analyses were performed to explore the associations between NLR and POF. The diagnostic performance of NLR was analysed using Receiver Operating Characteristic (ROC) curve analysis and the Delong test.Result: A total of 321 elderly patients with hip fractures were included; 120 (37.4%) of them were diagnosed with POF. Univariate analysis indicated significant differences in NLR, platelet-to-lymphocyte ratio (PLR), education, neutrophil count, lymphocyte count, Hamilton Depression Scale (HAMD) and Insomnia Severity Index (ISI) scores (P<0.05). Multivariate analysis indicated neutrophil count (odds ratio [OR], 1.46; 95% confidence interval [CI] 1.27–1.67), lymphocyte count (OR 0.32, 95% CI 0.19–0.53), NLR (OR1.81, 95% CI 1.50–2.17) and PLR (OR 1.005, 95% CI 1.001–1.009) were significantly associated with POF. The areas under the ROC curves (AUCs) of neutrophil count, lymphocyte count, NLR and PLR were 0.712, 0.667, 0.775 and 0.605, respectively. The Delong test indicated that NLR had the best diagnostic performance (p < 0.05).Conclusion: NLR independently predicts POF in elderly patients with acute hip fracture.

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Section: Discussionsupporting

confidence: 93%

Association Between Neutrophil-To-Lymphocyte Ratio and Postoperative Fatigue in Elderly Patients with Hip Fracture

Jing

Wang

Chen

et al. 2022

Preprint

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“…Thus, a positive association has been reported between postoperative fatigue and age in patients after elective abdominal surgery 41 and gastrointestinal tumor surgery. 42 Also, the percentage of older people who experience fatigue in daily activities seems to increase significantly between 70 and 85 years-of-age, and can be related to loss of functional ability. 43 This was not the case in the present study.…”

Section: Discussionmentioning

confidence: 99%

Fatigue, fear of being mobilized and residual limb pain limit independent basic mobility and physiotherapy for patients early after major dysvascular lower extremity amputation: A prospective cohort study

Berger,

Nielsen,

Stie

et al. 2024

Geriatrics Gerontology Int

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AimEarly mobilization of patients with a major lower extremity amputation (LEA) is often a challenge because of lack of compliance. Therefore, we investigated factors limiting independent mobility and physiotherapy on the first day with physiotherapy (PTDay1) and the following 2 days after LEA.MethodsA total of 60 consecutive patients, mean age 73.7 years (SD 12.1 years), undergoing LEA were included over a period of 7 months. The Basic Amputee Mobility Score was used to assess basic mobility. Predefined limitations for not achieving independent mobility or not completing physiotherapy were residual limb pain, pain elsewhere, fear of being mobilized, fatigue, nausea/vomiting, acute cognitive dysfunction or “other” factors reported on PTDay1 and the following 2 days after LEA.ResultsFatigue and fear of being mobilized were the most frequent limitations for not achieving independent mobility on PTDay1 and the following 2 days after LEA. Patients (n = 55) who were not independent in the Basic Amputee Mobility Score activity transferring from bed to chair on PTDay1 were limited by fatigue (44%) and fear of being mobilized (33%). A total of 21 patients did not complete planned physiotherapy on PTDay1, and were limited by fatigue (38%), residual limb pain (24%) and “other” factors (24%).ConclusionFatigue and fear of being mobilized were the most frequent factors that limited independent mobility early after LEA. Fatigue, residual limb pain and “other” factors limited completion of physiotherapy. Geriatr Gerontol Int 2024; ••: ••–••.

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“…This can be related to the series of vicious cycles between physical frailty and social frailty. Postoperative elderly patients with gastric cancer often suffer from postoperative fatigue (POF) and some speci c postoperative physical issues such as intolerance of oral intake, intra-abdominal abscess, and delayed gastric emptying, resulting in severe reduction of social activities [37][38] . In parallel, the limited social activities probably contribute to a decline in skeletal muscle metabolism, which in turn leads to muscle atrophy, reduced physical performance, and impaired independence 39 .…”

Section: Discussionmentioning

confidence: 99%

Comparing the Adverse Outcomes of Different Frailty Subgroups by Employing the Tilburg Frailty Indicator (TFI) Among Elderly Patients with Gastric Cancer

Miao

Ding

et al. 2022

Preprint

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Purpose: To classify the frailty subgroups by employing the Tilburg Frailty Indicator (TFI), as well as exploring the differences in postoperative total complications, length of stay (LOS), disability, and quality of life (QOL) between each subgroup among preoperative elderly gastric cancer patients.Methods: Overall 290 patients were enrolled in this follow-up study. The TFI was used to collect the information of physical, psychological, and social frailty. The data of total complications and LOS were provided from the electronic medical records, while the data of disability and QOL were obtained from the telephone at 30 days after discharge.Results: The TFI divided the preoperative elderly gastric cancer patients into eight frailty subgroups: exclusive physical frailty (18.3%), exclusive psychological frailty (20%), exclusive social frailty (3.4%), physical and psychological frailty (14.5%), physical and social frailty (3.4%), psychological and social frailty (3.4%), multidimensional frailty (4.8%) and full robust subgroup (32%). The multidimensional frailty subgroup had worse outcomes in total complications (P=0.001) and LOS (P＜0.001) while the subgroup of physical and social frailty had poorer QOL (P=0.015) at 30 days after discharge. Conclusion: The multidimensional frailty subgroup and the physical and social frailty subgroup should be of particularly concerned in the hospital and outside hospital according to our study. It also indicates that prehabilitation strategies can be developed precisely based on reported items to improve functional status of elderly gastric cancer patients. Further studies are needed to conduct in a longer-term period to capture significant change of other outcome indicators.

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Risk factors and the utility of three different kinds of prediction models for postoperative fatigue after gastrointestinal tumor surgery

Cited by 20 publications

References 27 publications

Association Between Neutrophil-To-Lymphocyte Ratio and Postoperative Fatigue in Elderly Patients with Hip Fracture

Association Between Neutrophil-To-Lymphocyte Ratio and Postoperative Fatigue in Elderly Patients with Hip Fracture

Fatigue, fear of being mobilized and residual limb pain limit independent basic mobility and physiotherapy for patients early after major dysvascular lower extremity amputation: A prospective cohort study

Comparing the Adverse Outcomes of Different Frailty Subgroups by Employing the Tilburg Frailty Indicator (TFI) Among Elderly Patients with Gastric Cancer

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