Risk Factors Associated With Atrioventricular Block

Kerola, Tuomas; Eranti, Antti; A, Aro; Haukilahti, M. Anette E.; Holkeri, Arttu; Junttila, M. Juhani; Kenttä, Tuomas; Rissanen, Harri; Vittinghoff, Eric; Knekt, Paul; Heliövaara, Markku; Huikuri, Heikki V.; Marcus, Gregory M.

doi:10.1001/jamanetworkopen.2019.4176

Cited by 65 publications

(48 citation statements)

References 40 publications

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“…While not commonly known it has been established that conduction disorders are associated with diabetes mellitus. In a population‐based cohort study investigating 6.146 community‐dwelling individuals, increased fasting glucose levels were associated with the development of AVB 17 . In a cross‐sectional analysis of 845.747 patients at a US Veterans Health Administration hospitals, Movahed et al found diabetes to be strongly associated with third‐degree heart block 18 .…”

Section: Discussionmentioning

confidence: 99%

Tricuspid valve annuloplasty and mitral valve replacement are associated with bradyarrhythmia after mitral valve surgery

Herrmann

Schleith

Graf

et al. 2021

Cardiovasc electrophysiol

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Introduction Mitral valve surgery has developed into a strong subspecialty of cardiac surgery with operative techniques and outcomes constantly improving. The development of bradyarrhythmias after mitral valve surgery is not completely understood. Methods We investigated a cohort of 797 patients requiring mitral valve surgery with and without concomitant procedures. Incidences and predictors of pacemaker requirement as well as survival were analyzed. Results In the complete follow‐up period (median follow‐up time: 6.09 years [95% confidence interval [CI]: 5.94–6.22 years, maximum 8.77 years) 80 patients (10% of the complete cohort) required pacemaker implantation for bradyarrhythmia. The cumulative rate of pacemaker implantation was 6.4% at 50 days (48 patients) with most (54.2%) requiring pacing for atrioventricular block. Mitral valve replacement (odds ratio [OR]: 1.905; 95% CI: 1.206–3.536; p = .041) and tricuspid ring annuloplasty (OR: 2.348; 95% CI: 1.165–4.730, p = .017) were identified as operative risk factors of pacemaker requirement after mitral valve surgery. Insulin‐dependent diabetes mellitus was also identified as a predictor of pacemaker requirement (OR: 4.665; 95% CI: 1.975–11.02; p = .001). There was no difference in survival in the paced and unpaced groups. Conclusions After mitral valve surgery, a relevant subgroup of patients requires pacemaker implantation—most for atrioventricular block. We identified mitral valve replacement and tricuspid ring annuloplasty as significant operative risk factors and insulin‐dependent diabetes mellitus as a demographic risk factor. While anatomic relationships help explain the operative risk factors the role of diabetes mellitus is not completely understood.

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Section: Discussionmentioning

confidence: 99%

Tricuspid valve annuloplasty and mitral valve replacement are associated with bradyarrhythmia after mitral valve surgery

Herrmann

Schleith

Graf

et al. 2021

Cardiovasc electrophysiol

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“…Fibrosis is also a pathophysiological hallmark of atrial fibrillation (Gal & Marrouche, ; Kottkamp, ), which has a prevalence of ~9% in those >65 years old and is a major risk factor for stroke (Piccini et al, ; Staerk, Sherer, Ko, Benjamin, & Helm, ). In the conduction system, fibrosis causes bradyarrhythmia and heart block, a substantial cause of morbidity in the elderly (Csepe, Kalyanasundaram, Hansen, Zhao, & Fedorov, ; Kerola et al, ). Risk factors for cardiac fibrosis are diverse and include hypertension (Cuspidi, Ciulla, & Zanchetti, ), ischaemic heart disease (Hinderer & Schenke‐Layland, ), aortic stenosis (Bing et al, ; Katbeh et al, ), inherited cardiomyopathy (Gulati et al, ; Ho et al, ), diabetes (Russo & Frangogiannis, ), and ageing (Lu et al, ).…”

Section: Fibrosis: a Final Common Pathway Underlying Cardiac And Renamentioning

confidence: 99%

IL‐11 in cardiac and renal fibrosis: Late to the party but a central player

Corden

Adami

Sweeney

et al. 2020

British J Pharmacology

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Fibrosis is a pathophysiological hallmark of cardiorenal disease. In the heart, fibrosis leads to contractile dysfunction and arrhythmias; in the kidney, it is the final common pathway for many diseases and predicts end‐stage renal failure. Despite this, there are currently no specific anti‐fibrotic treatments available for cardiac or renal disease. Recently and unexpectedly, IL‐11 was found to be of major importance for cardiorenal fibroblast activation and fibrosis. In mouse models, IL‐11 overexpression caused fibrosis of the heart and kidney while genetic deletion of Il11ra1 protected against fibrosis and preserved organ function. Neutralizing antibodies against IL‐11 or IL‐11RA have been developed that have anti‐fibrotic activity in human fibroblasts and protect against fibrosis in murine models of disease. While IL‐11 biology has been little studied and, we suggest, largely misunderstood, its autocrine activity in myofibroblasts appears non‐redundant for fibrosis, which offers new opportunities to better understand and potentially target cardiorenal fibrosis.

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“…(56.1%) were women, 6 where our study was carried out on evaluation of risk factors among myocardial infarction inpatients in department of coronary care unit(CCU) in territory care hospital. There is a need of providing a proper patient education regarding disease and its associated risk factors in order to minimize the recurrent chances of MI.…”

Section: Resultsmentioning

confidence: 99%

Epidemiological Study of Risk Factors in Myocardial Infarction Patients

Sushritha¹,

Sharma²,

Suman³

et al. 2020

JYP

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Introduction: Recent ecological study for major CVD risk factors and mortality indicates a high correlation between expected and observed mortality rates for three major risk factors-hypertension, diabetes, smoking. Survivor of MI are at higher risk of recurrent infarction than in people who don't have coronary heart disease. Objectives: To evaluate the risk factors of Myocardial Infarction among cardiac patients and provide patient education in order to minimize risk factors. Methods: A prospective and observational study was conducted on 500 medical records of cardiac department. Data was collected by using a case report form from September 2019 to December 2019 and then analyzed using statistical package for social science (SPSS) version 20.0 software. Results: We have assessed around 500 myocardial infarction cases, Out of which higher proportion of risk factors in myocardial infarction patients has been observed in Coronary Artery Disease (31%), Hypertension (20.9%), followed by Diabetes Mellitus (15.01%), Smoking (12.5%), Alcohol consumption (12.3%), Obesity (3.09%) and any co-existing diseases (4.75%). Conclusion: On the whole, this study indicates that evaluation of risk factors provides new scope for the development of more effective approaches to prevent the recurrent chances of myocardial infarction by providing patient education and life style modification.

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Risk Factors Associated With Atrioventricular Block

Cited by 65 publications

References 40 publications

Tricuspid valve annuloplasty and mitral valve replacement are associated with bradyarrhythmia after mitral valve surgery

Tricuspid valve annuloplasty and mitral valve replacement are associated with bradyarrhythmia after mitral valve surgery

IL‐11 in cardiac and renal fibrosis: Late to the party but a central player

Epidemiological Study of Risk Factors in Myocardial Infarction Patients

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