Risk factors associated with coronary heart disease in women: a systematic review

Bai, Mei; Wang, X.

doi:10.1007/s00059-019-4835-2

Cited by 38 publications

(27 citation statements)

References 45 publications

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“…Furthermore, our study also showed that lnc‐GAS5 was negatively correlated with HDL‐C; meanwhile, miR‐21 was negatively correlated with TC, which could be resulted from their regulation on cholesterol and intracellular lipid accumulation in atherosclerosis 9 . Several reports have shown that HDL‐C and TC are potential risk factors for CHD 29,30 . Thus, it could be inferred that lnc‐GAS5 and miR‐21 regulated lipid metabolism to indirectly promote CHD progression.…”

Section: Discussionsupporting

confidence: 57%

Relation of circulating lncRNA GAS5 and miR‐21 with biochemical indexes, stenosis severity, and inflammatory cytokines in coronary heart disease patients

Jiang

2022

Clinical Laboratory Analysis

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Background Long noncoding RNA GAS5 (lnc‐GAS5) and its target microRNA‐21 (miR‐21) regulate blood lipid, macrophages, Th cells, vascular smooth muscle cells to participate in atherosclerosis, and related coronary heart disease (CHD). The study aimed to further explore the linkage of their circulating expressions with common biochemical indexes, stenosis severity and inflammatory cytokines in CHD patients. Methods Ninety‐eight CHD patients and 100 controls confirmed by coronary angiography were enrolled. Plasma samples were collected for lnc‐GAS5 and miR‐21 detection by reverse transcription‐quantitative polymerase chain reaction and inflammatory cytokines determination by enzyme‐linked immunosorbent assay. Results Lnc‐GAS5 was increased in CHD patients compared with controls (2.270 (interquartile range [IQR]: 1.676–3.389) vs. 0.999 ([IQR: 0.602–1.409], p < 0.001), whereas miR‐21 showed opposite tread (0.442 [IQR: 0.318–0.698] vs. 0.997 [IQR: 0.774–1.368], p < 0.001). In aspect of their intercorrelation, lnc‐GAS5 negatively linked with miR‐21 in CHD patients (p < 0.001) instead of controls (p = 0.211). Interestingly, among the common biochemical indexes, lnc‐GAS5 related to decreased high‐density lipoprotein cholesterol (p = 0.008) and increased C‐reactive protein (CRP) (p < 0.001), while miR‐21 correlated with lower total cholesterol (p = 0.024) and CRP (p < 0.001) in CHD patients. As stenosis degree, lnc‐GAS5 positively correlated with Gensini score (p < 0.001), but miR‐21 exhibited negative association (p = 0.003) in CHD patients. In terms of inflammatory cytokines, lnc‐GAS5 positively related to tumor necrosis factor α (TNF‐α) and interleukin (IL)‐17A, while miR‐21 negatively linked with TNF‐α, IL‐1β, IL‐6, and IL‐17 in CHD patients (all p < 0.05). Conclusion Circulating lnc‐GAS5 and its target miR‐21 exhibit potency to serve as biomarkers for CHD management.

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Section: Discussionsupporting

confidence: 57%

Relation of circulating lncRNA GAS5 and miR‐21 with biochemical indexes, stenosis severity, and inflammatory cytokines in coronary heart disease patients

Jiang

2022

Clinical Laboratory Analysis

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“…2 Risk factors for CAD include disorders of lipid and lipoprotein metabolism, diabetes mellitus, hypertension, chronic kidney disease, smoking, diet, obesity, sex, lifestyle, age and family history. 1,3 It is estimated that the annual cost of CAD medical services in the US exceeds $200 billion and it results in a substantial economic burden. 4 Therefore, the early prediction of CAD is very important.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the association and predictive value of hyperhomocysteinaemia for obstructive coronary artery disease

Gao

Cao

et al. 2021

J Int Med Res

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Objective To investigate the predictive value of hyperhomocysteinaemia (HHcy) for obstructive coronary artery disease (CAD) in an Asian population in northern China. Methods This retrospective study enrolled patients at their first cardiac assessment and assigned them to an obstructive CAD group or a non-obstructive CAD group according to the coronary angiography results. HHcy was defined as a homocysteine (Hcy) level > 15 µmol/l. Results This study enrolled 2987 participants: 1172 in the non-obstructive CAD group and 1815 in the obstructive CAD group. Hcy level in the obstructive CAD group was significantly higher than in the non-obstructive CAD group. The proportion of patients with HHcy in the obstructive CAD group was significantly greater than in the non-obstructive CAD group. Multivariate logistic regression analysis demonstrated that HHcy was independently correlated with obstructive CAD in both young (aged ≤ 55 years) and old patients (aged > 55 years). HHcy showed a higher sensitivity (93.1%), specificity (86.1%) and accuracy (90.0%) for obstructive CAD. The odds ratio for HHcy was 84.2. The Kappa value (0.8) showed substantial agreement between obstructive CAD and HHcy. Conclusions HHcy was associated with obstructive CAD and may be a potentially independent risk factor for obstructive CAD with good predictive value.

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“…In addition, it could lead to a destructive influence on younger generations and their relatives ( 2 ). CAD is also referred to as the most popular angiocardiopathy and a significant risk regarding public hygiene ( 3 ). Another investigation also indicated that CAD was the major reason for mortality in the world, especially in low- and middle-income earners ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

“…CAD has several risk factors, including family history, age, obesity, smoking, passive smoking, physical activity, dyslipidemia, diabetes, hypertension, H-type hypertension, sleep, and so on ( 3 ). Hence, to not only reduce angina symptoms and exercise-induced ischemia but also prevent cardiovascular events, pharmacological intervention strategies, including antiplatelet drugs, anticoagulant drugs, statins and other lipid-lowering drugs, and renin–angiotensin–aldosterone (ACE) system blockers, are conducted.…”

Section: Introductionmentioning

confidence: 99%

Marine Natural Products and Coronary Artery Disease

Liang

Cai

2021

Front. Cardiovasc. Med.

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Coronary artery disease is the major cause of mortality worldwide, especially in low- and middle-income earners. To not only reduce angina symptoms and exercise-induced ischemia but also prevent cardiovascular events, pharmacological intervention strategies, including antiplatelet drugs, anticoagulant drugs, statins, and other lipid-lowering drugs, and renin–angiotensin–aldosterone system blockers, are conducted. However, the existing drugs for coronary artery disease are incomprehensive and have some adverse reactions. Thus, it is necessary to look for new drug research and development. Marine natural products have been considered a valuable source for drug discovery because of their chemical diversity and biological activities. The experiments and investigations indicated that several marine natural products, such as organic small molecules, polysaccharides, proteins, and bioactive peptides, and lipids were effective for treating coronary artery disease. Here, we particularly discussed the functions and mechanisms of active substances in coronary artery disease, including antiplatelet, anticoagulant, lipid-lowering, anti-inflammatory, and antioxidant activities.

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Risk factors associated with coronary heart disease in women: a systematic review

Cited by 38 publications

References 45 publications

Relation of circulating lncRNA GAS5 and miR‐21 with biochemical indexes, stenosis severity, and inflammatory cytokines in coronary heart disease patients

Relation of circulating lncRNA GAS5 and miR‐21 with biochemical indexes, stenosis severity, and inflammatory cytokines in coronary heart disease patients

Analysis of the association and predictive value of hyperhomocysteinaemia for obstructive coronary artery disease

Marine Natural Products and Coronary Artery Disease

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