Risk Factors Associated With Fragility Fracture Among Older Adults With Fragility Fracture: A Systematic Review

Abstract

Aim: To investigate risk factors of fragility fractures among older people. Data Sources: The electronic databases employed were PubMed, Science Direct, and Google Scholar from 2016 to December 2021. Review Method: The methodological quality of the studies was assessed using the National Institutes of Health (NIH) Quality Assessment Tool for Observational Cohort and Cross-sectional study. Two independent reviewers screened total 147 articles. Results: Twelve studies were finally included in this review that consisted of 7 cross sectional, 2 longitudinal and 3 cohort studies. Six studies were of good quality and six were fair. Studies that were of good quality showed that physical performance, muscle strength, and falls due to balance impairment were associated with an increased of fragility fractures. While the results for sarcopenia status were uncertain. Conclusion: This review suggests that physical functional related factors were main contributors to the risk of fragility fracture among older people. Lack of research in this area warrants more studies to be carried out in the future.

Handgrip Strength Is Positively Associated with 24-hour Urine Creatine Concentration

“…Handgrip strength (HGS) is an important health indicator for older adults, as its lower value is associated with adverse outcomes such as fragility and falls [ 1 , 2 ]. As described in a review study, a lower HGS is positively associated with the risk of fragility independently with various aging markers and physical functioning [ 1 ].…”

“…Handgrip strength (HGS) is an important health indicator for older adults, as its lower value is associated with adverse outcomes such as fragility and falls [ 1 , 2 ]. As described in a review study, a lower HGS is positively associated with the risk of fragility independently with various aging markers and physical functioning [ 1 ]. A recent prospective study showed that a greater HGS was associated with better functional outcomes after 1-year follow-up among fragility hip fracture patients [ 3 ].…”

Fragility and Resilience: Stories of Recovering From Hip Fractures in the Oldest-Old Age

“…The concept of 'fragility fracture' refers to so-called 'low-energy trauma' resulting in a fracture due to factors often associated with advanced age. Hip fracture is the most significant fragility fracture (Abd Kahar et al, 2022). The mortality rate is high and increases with age (Kristensen & Kehlet, 2018).…”