Risk factors associated with hepatitis C virus infection in an urban population of the State of Mexico

Figueroa, María del Socorro Romero; Ceballos-Salgado, E.; Santillán-Arreygue, L.; Miranda-García, Maximino; Rubio-Lezama, M.A.; Garduño-Garcia, Jose J

doi:10.1007/s00705-011-1149-y

Cited by 16 publications

(9 citation statements)

References 10 publications

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“…In recent studies done in Iran, the most prevalent genotype, was Type III[34] and studies in other countries including, Saudi Arabia revealed genotype IV as the most prevalent,[567] genotype Type II in Chinese and Brazilian prisoners,[89] Type II in Greek IVDUs[10] and Type I in other Countries. [11112]…”

Section: Discussionmentioning

confidence: 99%

The Correlation between Different Risk Factors of Hepatitis C and Different Genotypes

2017

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Background:Hepatitis C infection is one of the health problems in the world. Several known risk factors are responsible in transmission of this infection. We are going to study the prevalence of these risk factors for different genotypes of hepatitis C and if possible, specify probable relations between each risk factor and transmission of each genotype.Materials and Methods:This is a cross-sectional study done on 270 people who had positive anti-hepatitis C virus (HCV) antibody and HCV RNA. Demographic specificity and possible risk factors were collected using a questionnaire, and statistical analysis was done by SPSS software (version 20). Chi-square test used to estimate the prevalence and relation between each qualitative risk factor and HCV genotype transmitted. Analysis of variance was used for studying the prevalence and relation between quantitative risk factors and HCV genotypes.Results:The sample size was 270 persons. Of these, 217 (80.4%) were men and 185 (68.5%) were infected with genotype Type III. Most people were in age range of 31–40 years old 92 (34%). Single people were 126 (46.7%) and 169 (62.6%) were high school and university graduated. Tattooing as a risk factor had a meaningful relation with hepatitis C genotype (P < 0.001).Conclusions:According to the findings, most people in central provinces of Iran with hepatitis C are carrying genotype III, with most prevalent risk factors such as intravenous drug use and unsafe sexual activity. Besides, tattooing had a significant association with hepatitis C genotype, so that in these groups of people, genotype I was more frequent isolated virus.

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Section: Discussionmentioning

confidence: 99%

The Correlation between Different Risk Factors of Hepatitis C and Different Genotypes

2017

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“…Several epidemiological studies of HCV performed in Mexican people that included blood donors, [28-30] open population, [31,32] and patients with cirrhosis [33] mentioned dental treatment as a probable risk factor. Other studies found that living with a family member infected with HCV [34,35] or suffering from liver disease [33,36,37] was an associated risk factor. Although it is known that multiple factors contribute to HCV transmissibility for saliva [5,38] and viral loads are very low in this [39].…”

Section: Discussionmentioning

confidence: 99%

Detection of hepatitis C virus RNA in saliva of patients with active infection not associated with periodontal or liver disease severity

et al. 2014

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BackgroundHepatitis C virus (HCV) is mainly transmitted by parenteral route, being blood transfusion and intravenous drug use the most frequent risk factors. However, it has been suggested that there are other routes of transmission. There are several studies where HCV RNA has been detected in saliva of patients infected with HCV, and epidemiological studies have proposed the dental treatments as possible risk factors for HCV transmission. The purpose of this study was to detect the presence of HCV RNA in saliva of patients with active infection and associating with periodontal or liver disease.MethodsPatients with quantifiable HCV-RNA in serum were enrolled in the study. Periodontal disease was assessed using the modified gingival index (MGI). Presence of dental plaque was assessed with the use of disclosing tablets. Patients were clinically and laboratory evaluated to identify the stage of liver disease, the HCV RNA was determinate in saliva by nested RT-PCR. To determine associations between different parameters univariate and multivariate analysis were used.ResultsA total of 45 patients were included. Of these patients, 21 (46.6%) had hepatitis, 23 (51.1%) had cirrhosis and one patient (2.4%) presented hepatocellular carcinoma (HCC). Viral loads in serum ranged from 2.31–6.68 log IU/ml with a mean of 5.46 log IU/ml (95% CI 5.23–5.70). HCV RNA was positive in saliva of 29 patients (64.4%) and was not detected in 16 (35.6%). For univariate analysis three independent variables were associated with the detection of HCV-RNA in saliva: gender, viral load and dental plaque and multivariate analysis only one independent variable viral load >5.17 log IU/mL remained significantly associated with the detection of HCV in saliva (p = 0.0002). A statistical difference was observed when viral load was analyzed, log 5.85 IU/mL (95% CI 5.67–6.02) for patients with HCV in saliva vs. log 4.77 IU/mL (95% CI 4.35–5.19) for patients without HCV in saliva (p = 0.0001). The detection of HCV-RNA in saliva was more frequent in patients with relatively high serum viral loads.ConclusionHCV-RNA in saliva was associated with the level of serum viral load but not with periodontal or liver disease severity.

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“…The most common forms of viral transmission are related to the use of intravenous drugs, blood transfusion, multiple sexual partners, tattooing, piercings and perinatal origin (2). On the other hand in developing countries such as Mexico the most common cause of HCV transmission are blood transfusion and products (3).…”

Section: Introductionmentioning

confidence: 99%

Treatment of Hepatitis C According to Regional Treatment Guidelines

Figueroa¹,

Horta-Baas²,

Gamboa-Cardeña³

et al. 2017

West Indian Med J

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Objective: Was present a general overview of the current treatments for HCV infection in adults. Methods: A review study was conducted, Databases such as PubMed, MEDLINE and Scopus were used as information sources to identify and analyze the current information about the treatment for HCV infection in adults Results: To define a treatment with the best likelihood of success, it is important to identify in each patient, their response predictors such as genotype and viral load as vital determinants. In addition, to age, male gender, prolonged infection, cirrhosis, hepatic fibrosis, elevated plasma ferritin, obesity, insulin resistance, African American and Hispanic ancestry and co-infection with HIV). Recently, it has been approved that the other drugs with direct antiviral activity (DAAs), like the protease inhibitors (Boceprevir and Telaprevir), inhibitors of the polymerase NS5B (deleobuvir and setrobuvir), inhibitors of replication complex NS5A, include daclatasvir, ledipasvir and cyclophilin inhibitors were introduced into clinical practice but this use is subject to the purchasing power of health institutions Conclusion: To define a treatment with the best likelihood of success, it is important to identify in each patient, their response predictors such as genotype and viral load as vital determinants.

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Risk factors associated with hepatitis C virus infection in an urban population of the State of Mexico

Cited by 16 publications

References 10 publications

The Correlation between Different Risk Factors of Hepatitis C and Different Genotypes

The Correlation between Different Risk Factors of Hepatitis C and Different Genotypes

Detection of hepatitis C virus RNA in saliva of patients with active infection not associated with periodontal or liver disease severity

Treatment of Hepatitis C According to Regional Treatment Guidelines

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