Risk Factors Associated With Lung Retransplantation: Evaluation of a Nationwide Registry Over a Quarter Century

Hayanga, Jeremiah A; Yang, Jingyan; Aboagye, Jonathan; Berko, Charles; Qiao, Congzhen; Kaiser, Heather E.; Shigemura, Norihisa; D’Cunha, Jonathan

doi:10.1016/j.athoracsur.2014.06.033

Cited by 13 publications

(5 citation statements)

References 22 publications

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“…Our results provide strong evidence that lung retransplantation for CLAD is an effective strategy, with acceptable short-and mid-term outcomes comparable with those of primary LTx. Our results are similar to other published and registry data reviews demonstrating similar long-term outcomes [3,[13][14][15][16][17]. This is an important finding that illustrates the dramatic improvement of retransplantation outcomes over the past two decades [18][19][20].…”

Section: Commentsupporting

confidence: 90%

Lung Retransplantation for Chronic Rejection: A Single-Center Experience

Roy

Panchanathan

Walia

et al. 2018

The Annals of Thoracic Surgery

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Section: Commentsupporting

confidence: 90%

Lung Retransplantation for Chronic Rejection: A Single-Center Experience

Roy

Panchanathan

Walia

et al. 2018

The Annals of Thoracic Surgery

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“…of double-lung ReLTx over single-lung ReLTx. 13 A more recently published study, based on the same registry, showed no significant difference in graft survival after retransplantation with single or double lungs when stratified by previous transplant type. 14 The authors of the latter study suggest that single ReLTx should be considered, regardless of the previous transplant type, in an effort to optimize organ resources.…”

Section: Commentmentioning

confidence: 91%

Outcomes and Long-term Survival After Pulmonary Retransplantation: A Single-Center Experience

Wallinder

Danielsson

Magnusson

et al. 2019

The Annals of Thoracic Surgery

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Background. The median survival after lung retransplantation (ReLTx) reported to the International Society of Heart and Lung Transplantation is restricted to 2.5 years. We report the results after ReLTx from our center.Methods. A retrospective data collection was performed for the 635 patients who underwent lung transplantation between 1991 and 2017 at our center. Recipient variables were compared between patients undergoing only primary lung transplantation (PLTx) and those undergoing PLTx and later ReLTx. Time to death was compared using the Kaplan-Meier method. The risk of ReLTx was analyzed in Cox regression models. Any interaction between type of transplantation, single/double, and PLTx/ReLTx was investigated.Results. ReLTx was performed in 49 patients. Survival after ReLTx at 30 days and 1, 2, and 5 years was 90%, 76%, 71%, and 55%, respectively, and the corresponding survival after PLTx was 94%, 82%, 76%, and 61%, respectively. A hazard ratio of 1.73 for ReLTx was shown (95% confidence interval [CI], 1.14 to 2.63; P [ .011). After adjustments for sex, age, diabetes, renal function, preoperative ventilator, and extracorporeal membrane oxygenation, the hazard ratio was 1.43 (95% CI, 0.90 to 2.26; P [ .13). ReLTx was performed in 8 patients (16%) within the first year after PLTx. The 1-year survival for this group was 50% compared with 81% (P [ .18) for patients who underwent ReLTx later than 1 year after the PLTx. Oneyear survival after double ReLTx was 60% (95% CI, 25% to 83%) compared with 79% (95% CI, 63% to 89%) for single ReLTx.Conclusions. ReLTx is a reasonable option for a selected group of patients. Ideally, a number of wellestablished risk factors are avoided and the ReLTx is performed more than 1 year after the PLTx.

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“…Multiple factors have been linked with poor outcomes in ReTx recipients, including preoperative ventilator dependence, functional status of the recipient, time to ReTx, recipient age, intensive care unit hospitalization, and institutional case volume [6,[8][9][10]. Prior work has shown decreased survival for ReTx performed for primary graft dysfunction (PGD) compared with ReTx for CLAD [7,[11][12][13][14].…”

mentioning

confidence: 99%