Risk factors associated with mortality in hospitalized patients with SARS-CoV-2 infection. A prospective, longitudinal, unicenter study in Reus, Spain

Iftimie, Simona; López‐Azcona, Ana F.; Vicente-Miralles, Manuel; Descarrega-Reina, Ramon; Hernández-Aguilera, Anna; Riu, Francesc; Simó, Josep M.; Garrido, Pedro; Joven, Jorge; Camps, Jordi; Castro, Antoni

doi:10.1101/2020.05.29.122986

Cited by 21 publications

(21 citation statements)

References 37 publications

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“…Interestingly, we observed more features associated with mortality in our cohort, but age seems to be the most important risk factor for COVID‐19, which is in line with other published studies 26,44‐47 . The predictive role of age is also confirmed by Sun et al, De Smet et al, 47 and Chen et al 45 studies.…”

Section: Discussionsupporting

confidence: 92%

Risk factors prediction, clinical outcomes, and mortality in COVID‐19 patients

Alizadehsani

Sani

Behjati

et al. 2020

Journal of Medical Virology

149

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Preventing communicable diseases requires understanding the spread, epidemiology, clinical features, progression, and prognosis of the disease. Early identification of risk factors and clinical outcomes might help in identifying critically ill patients, providing appropriate treatment, and preventing mortality. We conducted a prospective study in patients with flu‐like symptoms referred to the imaging department of a tertiary hospital in Iran between March 3, 2020, and April 8, 2020. Patients with COVID‐19 were followed up after two months to check their health condition. The categorical data between groups were analyzed by Fisher's exact test and continuous data by Wilcoxon rank‐sum test. Three hundred and nineteen patients (mean age 45.48 ± 18.50 years, 177 women) were enrolled. Fever, dyspnea, weakness, shivering, C‐reactive protein, fatigue, dry cough, anorexia, anosmia, ageusia, dizziness, sweating, and age were the most important symptoms of COVID‐19 infection. Traveling in the past 3 months, asthma, taking corticosteroids, liver disease, rheumatological disease, cough with sputum, eczema, conjunctivitis, tobacco use, and chest pain did not show any relationship with COVID‐19. To the best of our knowledge, a number of factors associated with mortality due to COVID‐19 have been investigated for the first time in this study. Our results might be helpful in early prediction and risk reduction of mortality in patients infected with COVID‐19.

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Section: Discussionsupporting

confidence: 92%

Risk factors prediction, clinical outcomes, and mortality in COVID‐19 patients

Alizadehsani

Sani

Behjati

et al. 2020

Journal of Medical Virology

149

View full text Add to dashboard Cite

show abstract

“…We have previously reported the main epidemiological and clinical characteristics and the mortality risk factors of the first wave patients during a month and a half between March and April [11]. In the present investigation we extended the study to mid-October to cover two equal periods of three and a half months.…”

Section: Discussionmentioning

confidence: 99%

First and second waves of coronavirus disease-19: A comparative study in hospitalized patients in Reus, Spain

Iftimie

López‐Azcona

Hernández-Flix

et al. 2020

Preprint

Self Cite

100

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Many countries have seen a two-wave pattern in reported cases of coronavirus disease-19 during the 2020 pandemic, with a first wave during spring followed by the current second wave in late summer and autumn. Empirical data show that the characteristics of the effects of the virus do vary between the two periods. Differences in age range and severity of the disease have been reported, although the comparative characteristics of the two waves still remain largely unknown. Those characteristics are compared in this study using data from two equal periods of 3 and a half months. The first period, between 15th March and 30th June, corresponding to the entire first wave, and the second, between 1st July and 15th October, corresponding to part of the second wave, still present at the time of writing this article. Two hundred and four patients were hospitalized during the first period, and 264 during the second period. Patients in the second wave were younger and the duration of hospitalization and case fatality rate were lower than those in the first wave. In the second wave, there were more children, and pregnant and post-partum women. The most frequent signs and symptoms in both waves were fever, dyspnea, pneumonia, and cough, and the most relevant comorbidities were cardiovascular diseases, type 2 diabetes mellitus, and chronic neurological diseases. Patients from the second wave more frequently presented renal and gastrointestinal symptoms, were more often treated with non-invasive mechanical ventilation and corticoids, and less often with invasive mechanical ventilation, conventional oxygen therapy and anticoagulants. Several differences in mortality risk factors were also observed. These results might help to understand the characteristics of the second wave and the behaviour and danger of SARS-CoV-2 in the Mediterranean area and in Western Europe. Further studies are needed to confirm our findings.

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“…In this study, cancer had the highest odds ratio among all other risk factors. Respiratory problems, especially chronic lung disease worsen the patients' condition and increase mortality [ 36 , 38 ]. A recent study showed that longer history of COPD results in more negative outcomes and more death rate [ 38 ].…”

Section: Discussionmentioning

confidence: 99%