Risk Factors Associated With Pediatric Acute Recurrent and Chronic Pancreatitis

Kumar, S. Sivaprasad; Ooi, Chee Y.; Werlin, Steven L.; Abu‐El‐Haija, Maisam; Barth, Bradley; Bellin, Melena D.; Durie, Peter R.; Fishman, Douglas S.; Freedman, Steven D.; Gariepy, Cheryl E.; Giefer, Matthew J.; Gonska, Tanja; Heyman, Melvin B.; Himes, Ryan; Husain, Sohail Z.; Lin, Tom K.; Lowe, Mark E.; Morinville, Véronique D.; Palermo, Joseph J.; Pohl, John F.; Schwarzenberg, Sarah Jane; Troendle, David M.; Wilschanski, Michael; Zimmerman, M. Bridget; Uç, Aliye

doi:10.1001/jamapediatrics.2015.4955

Cited by 233 publications

(278 citation statements)

References 39 publications

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“…stent placement) or surgical approaches 136,137 . Abdominal pain is a common complaint in children with CP, affecting ~80% children and leading to missed school days and increased health care costs 27,129,138 . There is very little written about pain management in childhood-onset CP.…”

Section: Prevention Of Pancreatic Function Should Be the Primary Goalmentioning

confidence: 99%

EPC/HPSG evidence-based guidelines for the management of pediatric pancreatitis

et al. 2018

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Section: Prevention Of Pancreatic Function Should Be the Primary Goalmentioning

confidence: 99%

EPC/HPSG evidence-based guidelines for the management of pediatric pancreatitis

et al. 2018

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“…For example, Wejnarska et al reported that 260 children with CP were screened for PRSS1, SPINK1 and CFTR, and the mutation most frequently found was in the SPINK1 gene (13). In one study involving 301 children, 155 had ARP and 146 had CP, and those patients with PRSS1 or SPINK1 mutations were more likely to present with CP when compared with ARP (14). The highest number of attacks among our patients with ARP occurred in the patient with a CFTR mutation and pancreatic divisum.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and Management of Pancreatitis in Childhood: A Single-Centre Experience

Appak¹,

Karakoyun²,

Cetin³

et al. 2018

Iran J Pediatr

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Background: Pancreatitis can be seen at any age in childhood. Therefore, it is important for pediatricians to know the diagnosis and the management of pancreatitis. Objectives: The aim of this study was to evaluate the etiological factors, clinical features and management of pancreatitis in children. Methods: This study included hospitalized children who were diagnosed with pancreatitis. The clinical presentations, laboratory analyses, radiological features, etiologies and treatments were recorded. Results: A total of 59 pancreatic attacks were recorded in 41 patients. The most common symptoms were abdominal pain and vomiting, and the most common etiological cause was idiopathic. Approximately 22% of the patients had acute recurrent episodes. Somatostatin was used to treat 61% of the attacks; however, it did not reduce the time to recovery after an attack when compared to those patients who did not use somatostatin (P = 0.36). The white blood cell counts and urea and calcium levels were significantly different between those patients who did and did not use somatostatin. Seventeen (28.8%) of the pancreatitis attacks were determined to be severe. Moreover, a mutation in the cystic fibrosis transmembrane conductance regulator was detected in two patients with recurrent pancreatitis. Conclusions: Fever and irritability can be signs of pancreatitis in infants and toddlers. In our cases, the somatostatin treatment was not effective in terms of the time to recovery after an attack.

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“…REDCap has been used successfully as their electronic data capture method, demonstrating its utility in multicenter pancreas research studies. Their prospective data from around 300 children have served to advance our understanding of the current status of pediatric pancreatitis, with published reports in high-impact journals [26,27].…”

Section: Discussionmentioning

confidence: 99%