Risk factors associated with reduced work productivity among people with chronic knee pain

Agaliotis, Maria; Fransen, Marlene; Bridgett, Lisa; Nairn, Lillias; Votrubec, M.; Jan, Stephen; Heard, Robert; Mackey, Martin

doi:10.1016/j.joca.2013.07.005

Cited by 44 publications

(35 citation statements)

References 30 publications

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“…Our findings thus suggest that knee pain negatively impact on physical aspects of health-related QoL, in line with data from the OAI 19 and the Research on Osteoarthritis Against Disability Study. 3 …”

Section: Discussionmentioning

confidence: 99%

Differences in Health-Related Quality of Life Among Subjects With Frequent Bilateral or Unilateral Knee Pain: Data From the Osteoarthritis Initiative Study

Bindawas¹,

Vennu²,

snih³

2015

J Orthop Sports Phys Ther

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STUDY DESIGN Cross-sectional study. OBJECTIVE To examine associations between frequent bilateral knee pain (BKP) and unilateral knee pain (UKP) and health-related quality of life (QoL). We hypothesized that frequent BKP would be associated with poorer health-related QoL than would frequent UKP and no knee pain. BACKGROUND Knee pain is one of the most frequently reported types of joint pain among adults in the United States. It is the most frequent cause of limited physical function, disability, and reduced QoL. METHODS Data were collected from the Osteoarthritis Initiative public-use data sets. Health-related QoL was assessed in 2481 participants (aged 45–79 years at baseline). The Knee Injury and Osteoarthritis Outcome Score QoL subscale (knee-specific measure) and the physical component summary and mental component summary (MCS) scores of the Medical Outcomes Study 12-Item Short-Form Health Survey (SF-12) (generic measure) were used to assess health-related QoL. Multiple regression analyses were used to examine the relationships between frequent knee pain and health-related QoL, adjusted for sociodemographic and health covariates. RESULTS Compared with subjects with no knee pain, subjects with frequent BKP and UKP had significantly lower scores on the Knee injury and Osteoarthritis Outcome Score QoL subscale (mean difference, −35.2; standard error [SE], 0.86; P<.001 and mean difference, −29.2; SE, 0.93; P<.001; respectively) and the SF-12 physical component summary score (mean difference, −6.25; SE, 0.41; P<.001 and mean difference, −4.10, SE, 0.43; P<.00; respectively), after controlling for sociodemographic and health covariates. The SF-12 MCS score was lower among those with BKP (−1.29; SE, 0.42; P<.001). Frequent UKP was not associated with the SF-12 MCS. CONCLUSIONS Subjects with frequent BKP had lower health-related QoL than those with frequent unilateral or no knee pain, as reflected in lower Knee injury and Osteoarthritis Outcome Socre QoL subscale and SF-12 physical component summary and MCS scores.

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Section: Discussionmentioning

confidence: 99%

Differences in Health-Related Quality of Life Among Subjects With Frequent Bilateral or Unilateral Knee Pain: Data From the Osteoarthritis Initiative Study

Bindawas¹,

Vennu²,

snih³

2015

J Orthop Sports Phys Ther

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“…The most common joint disease, osteoarthritis (OA), leads to absenteeism at work due to disability associated with joint pain and dysfunction1. Risk factors including obesity, aging, trauma, and lipid metabolism are etiological factors in OA.…”

mentioning

confidence: 99%

Dihydroartemisinin inhibits catabolism in rat chondrocytes by activating autophagy via inhibition of the NF-κB pathway

Jiang

Meng

Lee

et al. 2016

Sci Rep

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Osteoarthritis is a disease with inflammatory and catabolic imbalance in cartilage. Dihydroartemisinin (DHA), a natural and safe anti-malarial agent, has been reported to inhibit inflammation, but its effects on chondrocytes have yet to be elucidated. We investigated the effects of DHA on catabolism in chondrocytes. Viability of SD rats chondrocytes was analyzed. Autophagy levels were determined via expression of autophagic markers LC3 and ATG5, GFP-LC3 analysis, acridine orange staining, and electron microscopy. ATG5 siRNA induced autophagic inhibition. Catabolic gene and chemokine expression was evaluated using qPCR. The NF-κB inhibitor SM7368 and p65 over-expression were used to analyze the role of NF-κB pathway in autophagic activation. A concentration of 1 μM DHA without cytotoxicity increased LC3-II and ATG5 levels as well as autophagosomal numbers in chondrocytes. DHA inhibited TNF-α-induced expression of MMP-3 and -9, ADAMTS5, CCL-2 and -5, and CXCL1, which was reversed by autophagic inhibition. TNF-α-stimulated nuclear translocation and degradation of the p65 and IκBα proteins, respectively, were attenuated in DHA-treated chondrocytes. NF-κB inhibition activated autophagy in TNF-α-treated chondrocytes, but p65 over-expression reduced the autophagic response to DHA. These results indicate that DHA might suppress the levels of catabolic and inflammatory factors in chondrocytes by promoting autophagy via NF-κB pathway inhibition.

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“…However, a recent review8 found patients with hip or knee osteoarthritis were more likely to report reduced work capacity than the general population. A recent longitudinal study among people with chronic knee pain found that absenteeism was related to low psychological well-being, whereas presenteeism was associated with poor self-reported physical function and higher occupational physical demands 9. There has been a growing interest in conceptualising and adequately measuring the burden of reduced work productivity among people with painful knee osteoarthritis 10 11…”

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confidence: 99%

Burden of reduced work productivity among people with chronic knee pain: a systematic review

et al. 2014

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Risk factors associated with reduced work productivity among people with chronic knee pain

Cited by 44 publications

References 30 publications

Differences in Health-Related Quality of Life Among Subjects With Frequent Bilateral or Unilateral Knee Pain: Data From the Osteoarthritis Initiative Study

Differences in Health-Related Quality of Life Among Subjects With Frequent Bilateral or Unilateral Knee Pain: Data From the Osteoarthritis Initiative Study

Dihydroartemisinin inhibits catabolism in rat chondrocytes by activating autophagy via inhibition of the NF-κB pathway

Burden of reduced work productivity among people with chronic knee pain: a systematic review

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