Risk factors associated with rosacea

Abstract

Rosacea is foremost associated with familial predisposition. There is no association between Helicobacter pylori infection and rosacea in current study.

The Study of Prevalence of Helicobacter Pylori in Patients with Acne Rosacea

“…[25][26][27][28] Based on the different studies to date Lazaridou et al later concluded that due to the high prevalence of anti-Hp antibodies in humans in conjunction with the fact that the antibiotics are effective for both disease entities, it would be very difficult to stratify the population studied against all factors that influence both rosacea and H. pylori infection. 29 Similarly the trend for an increasing prevalence of H. pylori with severity of rosacea is suggested by the study reported by Diaz et al 30 Though the study did not achieve statistical significance a suggestion of a potential positive association between the severity of rosacea and both concurrent H. pylori infection and magnitude of anti-H. pylori CagA antigen humoral immune response was observed .Our study also shows that the mean values of anti H pylori IgG antibodies follow the linear trend. The measures of association was estimated with multiple correlation (R=0.447) showing a positive linear trend and the values increases with the clinical severity of rosacea has been supported statistically (F=5.74, df=1, P=0.025).…”

III Conferencia Española de Consenso sobre la infección por Helicobacter pylori

“…Algunos autores han relacionado la aparición y gravedad de estas lesiones con la infección por H. pylori, mientras que otros han descrito la mejoría de las mismas tras la erradicación 121---124 , pero los resultados de los estudios son controvertidos 125 . Así, los estudios de mayor tamaño muestral que han evaluado la prevalencia de H. pylori y su relación con la rosácea no evidencian una asociación estadísticamente significativa 126,127 ni señalan que la infección sea un factor de riesgo para esta enfermedad 128 .…”

An observational descriptive survey of rosacea in the Chinese population: clinical features based on the affected locations

“…The exact cause of rosacea remains unclear. It may contain hereditary components, and has been hypothesized to be associated with disorders of the innate immune system, dysfunction of facial vascular regulation, neurogenic inflammation, and elevated levels of Demodex mites, among others (Gibson, 2004; Yamasaki & Gallo, 2009; Abram et al, 2010; Steinhoff et al, 2011; Van Zuuren et al, 2015; Margalit et al, 2016). Morbidity of rosacea varies greatly among different ethnic populations, with a higher prevalence amongst fair-skinned individuals of northern European or Celtic ancestry (Spoendlin et al, 2012; Tuzun et al, 2014).…”