The purpose of this study is to determine the knowledge, attitude, and practice of self-medication of NSAIDs among adults in Alimosho Local Government Area (LGA) of Lagos State. The study is descriptive inferential form cross-sectional study that involved collection of data from adults in the LGA. The data collected from questionnaires administered to adults who were randomly selected across the LGA was analyzed to evaluate the association between demographic characteristics and knowledge, attitude, and practice of self-medication. The respondents who participated in the research were adults who were 18 years and above. Of the 652 respondents 50.8% were males and while 49.2% were females. Demographic profile and Information sources were tested for association with self-medication. Among respondents, 80.6% admitted that they are self-medicated, and a binary logistic regression was performed to ascertain the effect of gender, age, marital status, and educational attainment on the likelihood of respondents engaging in self-medication. The overall logistic regression was statistically significant, χ2 (1) = 24.824, p< 0.005. The model explained 10.2% (Nagelkerke R2) of the variance in self-medication and correctly classified 80.4% of cases. Keywords: Alimosho, Attitude, Knowledge, Lagos State, NAFDAC, NSAID, Perception, Self-medication.