Risk factors, causative organisms and sensitivity patterns of infective keratitis in a tertiary care hospital in Rawalpindi

Rizwan, Amna; Asghar, Asfandyar; Naqvi, Syed Ali Hasan; Sughra, Ume; Raza, Hassan

doi:10.47391/jpma.1410

Cited by 2 publications

(1 citation statement)

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“…Female preponderance in this study was primarily due to the use of contact lenses among females [ 17 ]. However, another study done in Pakistan showed that (61.5%) of patients were female and 38.4% of patients were male among the 65 cases of infective keratitis included in the study [ 18 ]. Hence, the gender distribution among the cases of corneal ulceration may vary depending on the country in which the study is being conducted.…”

Section: Discussionmentioning

confidence: 99%

Microbiological Profile in Patients Having Keratitis in a Tertiary Care Hospital in India

Pramanick¹,

Banerjee²,

Ghosh³

et al. 2022

Cureus

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BackgroundCorneal ulcer or keratitis is defined as a loss of corneal epithelium with underlying stromal infiltration and suppuration associated with signs of inflammation. Corneal blindness is a significant public health problem worldwide; infectious keratitis is one of the predominant preventable causes of blindness. Several studies have evaluated microbial infectious keratitis's etiology, management, and outcome. However, there are regional variations in corneal ulcers' prevalence, risk factors, and outcome. The objective of this study was to isolate and identify the bacterial, fungal, viral, and protozoal etiological organisms causing infectious corneal ulcers along with their prevalence and antimicrobial sensitivity pattern. MethodsA prospective observational study was done in the Department of Microbiology and RIO, Medical College & Hospital, Kolkata, for a period of 1 year (February 2019 to January 2020) after obtaining clearance from the Institutional Ethics Committee. Informed consent, demographic data, history of disease onset, duration of symptoms, associated co-morbidities, etc., were taken from the patients fulfilling the inclusion criteria. Corneal scraping samples were collected sterilely to detect bacterial, fungal, parasitic, and viral isolates and identified by standard laboratory procedures. ResultsA total of 80 patients were included in the study. The risk factors included foreign body in 24 (30%), blunt trauma in 10 (12.5%), steroid use in 8 (10%), contact lens user 4 (5%), and spontaneous in 34 (42.5%). Among these 80 patients, 18 showed growth of bacteria, including Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, and Pseudomonas aeruginosa; four had growth of fungi, including Aspergillus spp. and Fusarium spp, and two were positive for Herpes simplex virus by IFA. ConclusionEarly diagnosis and prompt keratitis treatment are critical for preventing visual loss. The identification of the various causative agents of keratitis is essential for the proper management of the cases.

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Section: Discussionmentioning

confidence: 99%

Microbiological Profile in Patients Having Keratitis in a Tertiary Care Hospital in India

Pramanick¹,

Banerjee²,

Ghosh³

et al. 2022

Cureus

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Pseudomonas Keratitis Predominance in Government Hospitals in Johor, Malaysia

Balasegar,

Md Saleh,

Thian Lung Than

et al. 2024

MJMHS

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Introduction: Keratitis is an eye-threatening condition, which requires immediate treatment, due to the rapid progression when the infection caused by Pseudomonas aeruginosa. This study aimed to describe the socio-demographic factors and risk factors related to Pseudomonas keratitis in selected six government hospitals in Johor, Malaysia. Methods: An 18 months cross-sectional study was conducted among bacterial keratitis patients from six government hospitals offering ophthalmology services in Johor, Malaysia. The cases were confirmed through a positive culture of Pseudomonas aeruginosa. All data on socio-demographic factors, risk factors, and symptoms were recorded using a data collection form and analysed using the Statistical Package for Social Sciences (SPSS) software version 26. Results: Fifty-five patients were diagnosed with Pseudomonas keratitis in this study. The majority of patients were males (65.5%) with a mean age of 41.22 years old. The majority of patients were of Malay ethnicity (60.0%). More than a quarter of cases are involved in office-oriented jobs (n=14, 25.5%). The major risk factors in this study were contact-lens usage (n=25, 45.5%), trauma (n=20, 36.4%), ophthalmic steroid usage (n=16, 29.1%), ocular surface disease (n=12, 21.8%) and previous eye surgery (n=4, 7.3%). This study found underlying medical illness (p=0.036) and ocular surface disease (p=0.051) are significantly associated with Pseudomonas keratitis. Conclusion: The present study is the first study in Malaysia focusing on Pseudomonas keratitis. This study provides additional information on the epidemiology data of keratitis in Malaysia. Future studies shall be extended to all government hospitals in Malaysia to obtain better insight on the disease burden of keratitis especially on Pseudomonas keratitis.

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Risk factors, causative organisms and sensitivity patterns of infective keratitis in a tertiary care hospital in Rawalpindi

Cited by 2 publications

References 0 publications

Microbiological Profile in Patients Having Keratitis in a Tertiary Care Hospital in India

Microbiological Profile in Patients Having Keratitis in a Tertiary Care Hospital in India

Pseudomonas Keratitis Predominance in Government Hospitals in Johor, Malaysia

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