Objective: Patient safety is a critical component of health care quality and measures created by the Agency for Healthcare Research and Quality (AHRQ) to identify hospitalizations with potentially preventable adverse events. This analysis evaluated whether Patient Safety Indicator (PSI) events following open (OSR) or endovascular (EVAR) repair of abdominal aortic aneurysm (AAA) were associated with increased risk of readmission. Methods: Patients undergoing elective repair of non-ruptured AAA from 2009 to 2012 were selected in the Medicare Provider Analysis and Review (MedPAR) files using the ICD-9-CM codes. To identify PSI events, we utilized the AHRQ Patient Safety Indicator ICD-9-CM numerator codes. Chi-square test, multivariable logistic regression analysis, non-parametric Wilcoxon rank sum test, and Kaplan-Meier survival analysis were used for statistics. Results: 66,923 patients undergoing elective AAA repair were evaluated: 9,315 with OSR and 57,608 with EVAR. The most frequent PSI events after OSR vs. EVAR were: postoperative respiratory failure (PSI 11; 17.7% vs. 1.8%, p<.0001); perioperative hemorrhage/hematoma (PSI 9; 3.6% vs. 2.6%, p<.0001); postoperative sepsis (PSI 13; 3.5% vs. 0.4%, p<.0001); accidental puncture or laceration (PSI 15; 2.1% vs. 0.6%, p<.0001); and postoperative acute kidney injury requiring dialysis (PSI 10; 1.4% vs. 0.2%, p<.0001). The overall 30-day readmission rate was 10.5%. The occurrence of any PSI event overall significantly increased 30-day readmission compared with no event cases (OR =1.71; 95% CI 1.57-1.86). Likelihood of 30-day readmission was greater for postoperative acute kidney injury requiring dialysis (OR=1.66; 95% CI 1.28-2.15), postoperative respiratory failure (OR=1.36; 95% CI 1.22-1.52), perioperative hemorrhage (OR=1.34; 95% CI 1.18-1.52), and postoperative pressure ulcer (OR=CI, 1.68-3.05). Occurrence of any PSI event was associated with an increased total hospital and ICU (Intensive Care Unit) length of stay and total hospital charges (all p<0.001).