Risk Factors for Anastomotic Leak After Colon Resection for Cancer

Abstract

Anastomotic leak after colon resection for cancer is a frequent, relevant complication. Patients, surgical technique, and hospital are all important determining factors of anastomotic leak risk.

Laparoscopic surgery may decrease the risk of clinical anastomotic leakage and a nomogram to predict anastomotic leakage after anterior resection for rectal cancer

“…Other studies obtained similar results (OR = 1.49–3.2) [5, 18, 23, 24]. The higher risk of AL in male patients may be due to their narrow pelvis, which leads to a more complicated operation compared to female patients with a broader pelvis.…”

Impact of hypertonic saline on postoperative complications for patients undergoing upper gastrointestinal surgery

“…HS may also reduce the inflammatory response and thereby reduce anastomotic leakage. [12,29] In the experimental setting, HS prevents adverse structural and functional alterations of the anastomotic position by improving the intestinal blood flow and modulating the systemic and local immune response. [30] This hypothesis on background mechanisms was not investigated in this study.…”

Self-Expanding Metallic Stent as a Bridge to Surgery in the Treatment of Left Colon Cancer Obstruction: Cost–Benefit Analysis and Oncologic Results

“…The long-term oncological and quality of life impact are well-established. [8][9][10][11] However, Frago et al have shown good results following emergency surgical resection, but only in selected cases performed by specialist colorectal surgeons. 13 In 1991, Dohmoto introduced the use of a self-expanding metallic stent (SEMS) as a palliative treatment for malignant Conclusions: The use of self-expanding metallic stents as a bridge to surgery is a safe option in the urgent treatment of obstructive left colon cancer, with similar short and long-term results compared to direct surgery, inferior mean costs and a higher rate of primary anastomosis.…”

“…[1][2][3] Despite medical and surgical advances, this emergency surgery continues to have a high morbidity (30-60%) and mortality (10-30%) compared to elective surgery (mortality rate less than 5%). [4][5][6][7][8] This difference could be for two reasons: first of all, in emergency surgery the patient is not adequately prepared and optimized in terms of hydration, nutritional status, electrolyte balance, etc. Moreover, emergency surgery is often performed by general surgeons rather than colorectal specialists, with a resulting ''surgeon-dependent'' negative effect.…”