2016
DOI: 10.1136/oemed-2015-103512
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Risk factors for and consequences of persistent lower respiratory symptoms among World Trade Center Health Registrants 10 years after the disaster

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Cited by 25 publications
(33 citation statements)
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“…These findings on acute pollution exposure on 9/11 are consistent with other analysis showing that persistent lower respiratory symptoms are strongly associated with a composite measure that included dust cloud exposure as well as experiencing or witnessing other traumatic events, which are ostensibly acute exposures (Friedman et al 2016). Other studies have reported the association between clinically based measures of lung function with arriving on 9/11/2001 among rescue workers up to 6 years after 9/11/2001 (Aldrich et al 2010; Wisnivesky et al 2011) and between dust or odor present more than 3 months with lower respiratory symptoms 2 years after 9/11/2001 among residents in lower Manhattan (Lin et al 2010; Reibman et al 2005).…”
Section: Discussionsupporting
confidence: 88%
See 1 more Smart Citation
“…These findings on acute pollution exposure on 9/11 are consistent with other analysis showing that persistent lower respiratory symptoms are strongly associated with a composite measure that included dust cloud exposure as well as experiencing or witnessing other traumatic events, which are ostensibly acute exposures (Friedman et al 2016). Other studies have reported the association between clinically based measures of lung function with arriving on 9/11/2001 among rescue workers up to 6 years after 9/11/2001 (Aldrich et al 2010; Wisnivesky et al 2011) and between dust or odor present more than 3 months with lower respiratory symptoms 2 years after 9/11/2001 among residents in lower Manhattan (Lin et al 2010; Reibman et al 2005).…”
Section: Discussionsupporting
confidence: 88%
“…PTSD at wave 1 was included as a risk factor in the multivariable model because it has been shown to be a contributing risk factor to the outcomes of interest in this study including heart disease (Jordan et al 2011) and lung problems (Friedman et al 2016). Multivariable analyses also included smoking status (current/former/never), and ever reporting hypertension.…”
Section: Methodsmentioning
confidence: 99%
“…While most participants with post-9/11 LRS experienced symptom resolution during the study period, LRS persisted for a nearly one-third of those with initial symptoms. Most (85%) participants with persistent LRS had normal spirometry at follow-up; however, more than half had abnormal IOS results, including elevated resistance (R 5 ) and frequency dependence of resistance (R [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20], suggesting that small airways dysfunction not detected on standard spirometry may underlie symptoms in this group. This was further supported by our finding that higher R 5 and R 5-20 values at exam 1 were associated with an increased odds of persistent LRS at follow-up.…”
Section: Discussionmentioning
confidence: 99%
“…Among participants with normal spirometry, cases were more likely than controls to have abnormal IOS findings, consistent with peripheral airway damage. 10 We and others have since documented the persistence of LRS among many 9/11-exposed persons [11][12][13] and have identified several factors that may cause or exacerbate LRS in this population. Among community members and local cleanup workers, persistent LRS were found to be associated with elevated markers of inflammation, including peripheral eosinophilia in those with wheezing 14 and C-reactive protein in those with abnormal IOS, 15 suggesting potential underlying mechanisms for the symptoms.…”
Section: Introductionmentioning
confidence: 96%
“…Furthermore, even in the absence of silicosis, the respiratory ailments associated with exposure to WTC dust have been well documented and may continue to develop in the future. Continued medical surveillance for respiratory conditions is required (Friedman et al, 2016).…”
Section: World Trade Center Dustmentioning
confidence: 99%