Risk factors for and impact of respiratory failure on mortality in the early phase of acute pancreatitis

Dombernowsky, Tilde; Kristensen, Marlene Østermark; Rysgaard, Sisse; Gluud, Lise Lotte; Novovic, Srdan

doi:10.1016/j.pan.2016.06.664

Cited by 44 publications

(42 citation statements)

References 14 publications

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“…Respiratory complications are very common in patients with acute pancreatitis. Hypoxemia can be the only manifestation in mild cases, and respiratory failure can occur in severe cases (59).…”

Section: Gastrointestinal Tract Involvementmentioning

confidence: 99%

“…In addition, systemic inflammatory response is also an important mechanism that leads to lung injury in acute pancreatitis. In acute pancreatitis, vasoactive substances and cytokines are released into the blood flow and into the lung tissue, which can lead to endothelial damage and capillary leakage; additionally, a large number of protein-rich exudates are released into the alveolar space, leading to interstitial pulmonary edema (59). MRI shows diffuse pulmonary exudative patches, bilateral lobular consolidation and pleural effusions (62) ( Figure 16).…”

Section: Gastrointestinal Tract Involvementmentioning

confidence: 99%

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MR imaging for acute pancreatitis: the current status of clinical applications

Sun¹,

Zuo²,

Lin³

et al. 2019

Ann. Transl. Med

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Acute pancreatitis is a common clinical acute abdomen. Imaging examinations play an important role in the management of acute pancreatitis. MR imaging is a noninvasive examination with high tissue contrast and a variety of acquisition sequences that can help determine the diagnosis, complications and severity of acute pancreatitis. The acute pancreatitis classification working group modified the Atlanta classification in 2012 to improve clinical evaluations and standardize the radiologic nomenclature for acute pancreatitis. In particular, the redefinition of necrotizing pancreatitis offers a new understanding of this disease. In clinical practice, there is still a lack of unifying standards between radiologists and physicians, such as for the imaging features of pseudocysts, walled-off necrosis, peripancreatic necrosis and especially for the MR imaging features of acute pancreatitis. In this article, we review the 2012 revised Atlanta classification of acute pancreatitis and recent advances in the clinical applications of MR imaging (MRI) in acute pancreatitis by showing how MRI can provide more optimized information for clinical diagnosis and treatment plan.

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Section: Gastrointestinal Tract Involvementmentioning

confidence: 99%

Section: Gastrointestinal Tract Involvementmentioning

confidence: 99%

MR imaging for acute pancreatitis: the current status of clinical applications

Sun¹,

Zuo²,

Lin³

et al. 2019

Ann. Transl. Med

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“…31,32 Reviews of randomised clinical trials evaluating interventions in patients with cirrhosis have identified a number of potential methodological problems. [33][34][35] These include potential biases associated with the allocation of intervention and blinding as well as the extent to which trials allowed generalization of results. However, to date, much less attention has been paid to the Trial endpoints in hepatic encephalopathy 5 importance of the selection, definition and reporting of trial endpoints; these are key determinants of the quality of the trial and hence the validity of the inferences that can be drawn from the outcomes.…”

Section: Evidence -Based Approach To the Conduct Of Randomised Clinicmentioning

confidence: 99%

“…Likewise, systematic reviews evaluating interventions in patients with cirrhosis have found that several of the included trials were not registered; were registered after the inclusion of the first participant; or reported endpoints which differed from those in the registered protocols. [33][34][35] Even journals that strongly support the ICMJE policy on trial registration are not adequately enforcing it. Thus, in a review of trials published in the six highest impact general medicine journals almost a third were registered retrospectively including 10% that were registered after an assessment of the primary endpoints would have been possible.…”

Section: Registration and Reporting Of Trial Endpointsmentioning

confidence: 99%

Outcomes in Clinical Trials Evaluating Interventions for the Prevention and Treatment of Hepatic Encephalopathy

Gluud

Jeyaraj

Morgan

2019

Journal of Clinical and Experimental Hepatology

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“…The mortality rate is over 30%, and the mortality rate of elderly patients is higher [1,2]. It is one of the main causes of death in early SAP patients [3][4][5]. At present, the research direction of SAP-induced acute lung injury (SAP-ALI) is mainly focused on inflammatory factor-mediated lung injury [6,7].…”

Section: Introductionmentioning

confidence: 99%

Effects of Bacterial Translocation and Autophagy on Acute Lung Injury Induced by Severe Acute Pancreatitis

Hanlin

Jiang

et al. 2020

Gastroenterology Research and Practice

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Aim. To reveal the role of bacterial translocation (BT) and autophagy in severe acute pancreatitis-induced acute lung injury (SAP-ALI). Methods. Rats were separated into a control (sham-operation) group (n=10) and a SAP group (n=30). Sodium taurocholate (5%) was retrogradely injected into the cholangiopancreatic duct to induce SAP-ALI in rats. Then, 16S rDNA sequencing was used to detect bacterial translocation (BT). Hematoxylin eosin staining (HE) was used to detect morphological changes to the pancreas, intestine, and lung. And lung tissue wet/dry weight ratio (W/D ratio) was used to assess the extent of pulmonary edema. The expressions of LC3II and Beclin1 proteins were analyzed by western blot and immunofluorescence. Glutathione peroxidase (GPx), malondialdehyde (MDA), and superoxide dismutase (SOD) were used to assess oxidative stress in lung tissue. Results. Levels of TNF-α, IL-6, lipase, and amylase in the SAP group were significantly higher than those in the control group (P<0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (P<0.01). LC3II expression was higher in the SAP-BT(-) group than that in the SAP-BT(+) group (P<0.01). The results were consistent with those of LC3II immunofluorescence assay. The expression of Beclin1 was similar to that of LC3II (P<0.01). MDA content in the SAP-BT(+) group was significantly higher than that in the SAP-BT(-) group (P<0.01), whereas SOD and GPX activities were opposite (P<0.01). Conclusions. BT can aggravate SAP-ALI with the increasing oxidative stress level, which may be related to the decrease of autophagy level.

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Risk factors for and impact of respiratory failure on mortality in the early phase of acute pancreatitis

Cited by 44 publications

References 14 publications

MR imaging for acute pancreatitis: the current status of clinical applications

MR imaging for acute pancreatitis: the current status of clinical applications

Outcomes in Clinical Trials Evaluating Interventions for the Prevention and Treatment of Hepatic Encephalopathy

Effects of Bacterial Translocation and Autophagy on Acute Lung Injury Induced by Severe Acute Pancreatitis

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